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Major depressive disorder (MDD) is the leading cause of disability worldwide and is expected to become the leading cause of the global disease burden by 2030. The "monoamine hypothesis of depression" suggests that monoamine deficiency is an important factor in the development of depression, therefore, the pharmacological mechanism of current first-line antidepressants is mainly to inhibit ... more |
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A research lab led by Prof. ZHENG Ping from Kunming Institute of Zoology of the Chinese Academy of Sciences has identified a p53-independent quality control factor which favors the rapid shutdown of the regulatory circuitry of pluripotency at the post-transcriptional levels, thereby ensuring robust differentiation and apoptosis in response to unrepaired DNA damage.
ESCs hold wide appli... more |
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A research lab led by Dr. ZENG Jianxiong from Kunming Institute of Zoology of the Chinese Academy of Sciences, in collaboration with Prof. ZHAO Zhen from Keck School of Medicine, University of Southern California, have discovered the cGAS-STING pathway-mediated innate immune mechanism underlying the development and progression of neurodegenerative Alzheimer's disease (AD).
AD mainly oc... more |
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A research lab led by Prof. SU Bing from Kunming Institute of Zoology of the Chinese Academy of Sciences, in collaboration with scientists from Tibetan University and Zhengzhou University, have discovered the key gene explaining the genetic adaptation of skin color of Tibetans.
Due to the long-time settlement at high altitude, Tibetans have been adapted to high altitude extreme environ... more |
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A research consortium led by Prof. ZHANG Guojie from Kunming Institute of Zoology of the Chinese Academy of Sciences has undertaken a seminal and major study spanning all recent penguin taxa to understand 60 million years of penguin evolutionary history and sheds new light on the evolutionary pathways that allowed some land animals to transition back into aquatic environments, particularly... more |
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