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Tumor Genome as “Living Fossil” Reveals Ancient Introgression from Coyotes to Pre-contact Dogs in North America

  Canine transmissible venereal tumor (CTVT), the oldest known somatic cell line, is a “living fossil” of the original host, transmitted from its tumor cells to other canids during the mating process. Since it was shown ten years ago that living cells from an ancient host could be transmitted among canids, the origin of CTVT has been studied continuously.
  Recent comparison of the CTVT ... more
Researchers Decipher Forces Shaping Maternal Genetic Landscape of Han Chinese

  As the world’s largest ethnic group, the genetic landscape of Han Chinese had been widely concerned during the last decades. Previous studies based on mitochondrial DNA (mtDNA) variants indicated a north-south maternal genetic divergence among Han populations. However, these studies mainly based on low-resolution mtDNA data of relatively limited samples, making the maternal genetic landsc... more
Scientists Lead to Reveal the Molecular Basis for Heat Desensitization of TRPV1 Ion Channels
 TRPV1 is an important temperature sensing element in mammals, which can be activated by high temperatures above 40°C. However, its role in sustained heat response remains poorly understood since a rapid heat-induced desensitization (Dh) process follows a tightly heat-induced activation (Ah) phase, and its function in mammalian biological activities remain elusive.
  Recently, scientists fro... more
Study reveals little evidence for a consistent diversity-disease relationship (DDR) in human microbiome associated diseases

  In a paper published last week in The ISME Journal, a team lead by Prof. MA Zhanshan (Kunming Institute of Zoology, Chinese Academy of Sciences) and Prof. Nicholas Gotelli (University of Vermont) discovered that, in only approximately 1/3 of cases, there is a statistical difference in the microbiome diversity of healthy versus diseased individuals.
  Launched a decade ago, the human micr... more
A new way of studying biological networks provides key insights into the ecology and etiology of human microbiome-associated diseases

  In a paper published in Ecological Monographs, Professors MA Zhanshan (also known as Sam Ma) from Kunming Institute of Zoology, Chinese Academy of Sciences and Aaron M. Ellison (Harvard University) presented a new way of analyzing networks of interacting organisms, which provides a powerful framework and supporting approaches for investigating the ecology and etiology of human microbiome a... more
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