Scientists
Education and Appointments
Education
Degree Field Institution Year
Ph.D. Developmental Biology Shandong University 1998
B.S./B.A. Zoology Shandong University 1993
Professional Experience
Position Institution Years
Postdoctoral Researcher German Cancer Research Center 1998.11-2003.12
Principle Investigator Kunming Institute of Zoology, CAS 2003.12-
Research Areas
Developmental mechanisms of the nervous system and pathogenesis of related neurological disorders.
Key research directions:
1. Regulatory roles of ubiquitination modification in neural cell differentiation and function;
2. Pathological functions of protein homeostasis regulation in neurodevelopmental disorders and neurodegenerative diseases;
3. Establishment of animal models for related diseases and development of therapeutic intervention strategies.
Supported Projects
1. National Key R&D Program of China, Key Technologies and Construction of Non-human Primate and Tree Shrew Models of Brain Diseases, Principal Investigator, 2021–2024
2. Yunling Scholar Project of Yunnan Revitalization Talent Support Program, Mechanisms of Neurodevelopmental/ Neurodegenerative Diseases and Development & Application of Primate Models, Principal Investigator, 2024–2029
Publications
1. Lu T, Ma P, Fang H, Chen A, Kuang X, Wang M, Su L, Wang S, Zhang Y, Wang J, Yang B, Shi D-L, Zhou Y, Gong Q, Liu X*, Mao B*, Shao M* (2025). Prkra dimer senses double-stranded RNAs to dictate global translation efficiency. Mol Cell, 85, 1–16.
2. Li Y, Wan LP, Song NN, Ding YQ, Zhao S, Niu J, Mao B*, Sheng N*, Ma P*. (2024) RNF220-mediated K63-linked polyubiquitination stabilizes Olig proteins during oligodendroglial development and myelination. Sci. Adv. 10: eadk3931.
3. Wang H#, Liu X#, Liu Y, Yang C, Ye Y, Yu X, Sheng N, Zhang S*, Mao B*, Ma P*. (2024) The E3 ubiquitin ligase RNF220 maintains hindbrain Hox expression patterns through regulation of WDR5 stability. eLife 13:RP94657.
4. Li Y, Wang H, Sun B，Su G, Cang Y, Zhao L, Zhao S, Li Y*, Mao B*, Ma P*. (2023). Smurf1 and Smurf2 mediated polyubiquitination and degradation of RNF220 suppresses Shh-group medulloblastoma. Cell Death Dis, 14: 494.
5. Ma P#, Wan LP#, Li Y#, He CH#, Song NN, Zhao S, Wang H, Ding YQ*, Mao B* and Sheng N*. (2022) RNF220 is an E3 ubiquitin ligase for AMPA receptors to regulate synaptic transmission，Science Advances, 8：eabq4736.
6. Guo X# , Ma P# , Li Y , Yang Y , Wang C, Xu T, Wang H, Li C, Mao B*, Qi X*. (2021). Rnf220 mediates K63-linked polyubiquitination of Stat1 and promotes host defense. Cell Death Diff. 28:640-656.
7. Song NN#, Ma P#, Zhang Q, Zhang L, Wang H, Zhang L, Zhu L, He CH, Mao B*, DingYQ*. (2020) Rnf220/Zc4h2-mediated monoubiquitylation of Phox2 is required for noradrenergic neuron development. Development, 147: dev185199.
8. Ma P#, An T#, Zhu L, Zhang L, Wang H, Ren B, Sun B, Zhou X, Li Y*, Mao B*. (2020) RNF220 is required for cerebellum development and regulates medulloblastoma progression through epigenetic modulation of Shh signaling. Development 147: dev188078.
9. Ma P#, Song NN#, Cheng X#, Zhu L, Zhang Q, Zhang L, Yang X, Wang H, Kong Q, Shi D*, Ding YQ*, Mao B*. (2020) ZC4H2 stabilizes RNF220 to pattern ventral spinal cord through modulating Shh/Gli signaling. J Mol Cell Biol. 12:337-344
10. Ma P#, Song NN#, Li Y#, Zhang Q, Zhang L, Zhang L, Kong Q, Ma L, Yang X, Ren B, Li C, Zhao X, Li Y, Xu Y, Gao X*, Ding YQ*, Mao B*. (2019) Fine-Tuning of Shh/Gli Signaling Gradient by Non-proteolytic Ubiquitination during Neural Patterning. Cell Reports, 28:541–553.
Member
Pengcheng Ma, Associate Professor
Huishan Wang, Assistant Professor
Yuwei Li, Assistant Professor
Yingqian Xia, Assistant Professor
Postgraduate Students:
Jingmei Cha, Jianlin Xu, Wei Li, Zhibiao Zhang, Jieya Zhou, Keran Yan, Zhouying Li
