Scientists

赖仞
Ren Lai / Principal Investigator
Lab/Research Group Name:Functional Proteomics of Natural Medicines
Email:rlai@mail.kiz.ac.cn
Zip Code:650223
Address:32 East Jiaochang Road, Kunming 650223, Yunnan, China
Position:Principal Investigator Director of the National-Local Joint Research Engineering Center for Natural Active Peptides, Director of the Yunnan Provincial Key Laboratory of Active Peptide Research and Application, and Director of the Engineering Laboratory for Natural Active Peptides, Chinese Academy of Sciences
Lab/Personal Website:https://kiz.cas.cn/sourcedb_kiz_cas/zw/zjrc/yjy/200908/t20090813_2394253.html
Other relevant platforms:ORCID ID: 0000-0002-3123-2336   ResearchGate: https://www.researchgate.net/profile/Ren-Lai-2

Education and Appointments

Education

Ph.D. Zoology Kunming Institute of Zoology, Chinese Academy of Sciences September 1995 - July 2001

B.S. Biology Southwest Normal University September 1991 - July 1995


Professional Experience

Kunming Institute of Zoology, Chinese Academy of Sciences Assistant Professor August 2001 - March 2002

University of Liverpool Postdoctoral April 2002 - June 2004

Kunming Institute of Zoology, Chinese Academy of Sciences Professor July 2004 - Present


Research Areas

Animal Environmental Adaptation Mechanisms, Structure-Function of Peptides, Pathogenesis of Human Diseases, and New Drug Development

Supported Projects

1. New Cornerstone Science Foundation New Cornerstone Professor Program Project Leader January 2023 - December 2027 25,000,000

2. National Natural Science Foundation of China Molecular mechanisms of centipedes subduing preys by using venoms Project Leader January 2020 - December 2024 3,632,000

3. Ministry of Science and Technology of the People's Republic of China National LaboratoryAnimal Resource Bank for Non-Human Primates Project Leader January 2020 - December 2025 22,500,000

4. National Natural Science Foundation of China Diversity of molecular resources from centipedes and their functions Project Leader January 2026 - December 2030 2,240,000

Yunnan Provincial Department of Science and Technology Industrialization Technology and New Product Development Platform for Active Peptides Project Leader January 2021 - December 2024 40,000,000

Awards and Honors

1. National Outstanding Youth Fund National Natural Science Foundation of China 2010

2. Second Prize of the National Technology Invention Award The State Council of the People's Republic of China 2013

3. National Innovation Excellence Award Ministry of Human Resources and Social Security of the People's Republic of China 2017

4. Outstanding Contribution Award of the State Administration of Traditional Chinese Medicine National Administration of Traditional Chinese Medicine 2017

5. First Prize of Yunnan Province Natural Science Award Yunnan Provincial People's Government 2018

Publications

1. Zhang H, Luo L, Liang Q, et al. Molecular evolution of sour tolerance in birds. Science. 2025;388(6753):1330-1336. doi:10.1126/science.adr7946

2. Cheng R, Tang X, Huang X, et al. Estrogen upregulates lactoferrin to induce hypercoagulability for hemostatic protection during pregnancy. Blood. 2026;147(14):1634-1646. doi:10.1182/blood.2025030270

3. Fang Y, Zhang Z, Cao Q, et al. Cathelicidin LL-37-ApoB-100 interaction promotes LDL clearance and attenuates cholesterol accumulation in the liver. Sci China Life Sci. 2026;69(2):492-505. doi:10.1007/s11427-025-3006-2

4. Huang X, Tang X, He Q, et al. High-fat diet increases circulating palmitic acid produced by gut Bacteroides thetaiotaomicron to promote thrombosis. Cell Rep Med. 2025;6(8):102260. doi:10.1016/j.xcrm.2025.102260

5. Liao Z, Wang C, Tang X, et al. Human transferrin receptor can mediate SARS-CoV-2 infection. Proc Natl Acad Sci U S A. 2024;121(10):e2317026121. doi:10.1073/pnas.2317026121

6. Fang M, Li Y, Liao Z, et al. Lipopolysaccharide-binding protein expression is increased by stress and inhibits monoamine synthesis to promote depressive symptoms. Immunity. 2023;56(3):620-634.e11. doi:10.1016/j.immuni.2023.02.002

7. Jin L, Jiang BG, Yin Y, et al. Interference with LTβR signaling by tick saliva facilitates transmission of Lyme disease spirochetes. Proc Natl Acad Sci U S A. 2022;119(47):e2208274119. doi:10.1073/pnas.2208274119

8. Li M, Tang X, Liao Z, et al. Hypoxia and low temperature upregulate transferrin to induce hypercoagulability at high altitude. Blood. 2022;140(19):2063-2075. doi:10.1182/blood.2022016410

9. Tang X, Zhang Z, Fang M, et al. Transferrin plays a central role in coagulation balance by interacting with clotting factors. Cell Res. 2020;30(2):119-132. doi:10.1038/s41422-019-0260-6

10. Shen C, Liu M, Xu R, et al. The 14-3-3ζ-c-Src-integrin-β3 complex is vital for platelet activation. Blood. 2020;136(8):974-988. doi:10.1182/blood.2019002314

Member

Lu Qiumin Senior Engineer

Luo Lei Professor

Duan Zilei Associate Professor

Fang Yaqun Associate Professor

Zhang Hao Associate Professor

Zhao Qi Associate Professor

Li Juan Assistant Professor

Li Juan Assistant Professor

Li Juan Assistant Professor

Wang Chaoming Assistant Professor

Su Deyuan Assistant Professor

Su Deyuan Assistant Professor

Li Zongxu Assistant Professor

Hu Jingmei Assistant Professor

Liao Zhiyi Assistant Professor

Zhang Xingxian Assistant Professor

Cao Kaixun Assistant Professor

Yang Min Assistant Professor

Wang Ziyi Research Assistant

Guo Min Research Assistant