Scientists
Education and Appointments
Education
l Ph.D. in Science (2000 – 2005) Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, China
l B.S. in Virology (1996 – 2000) Wuhan University, China
l Principal Investigator / Professor (May 2012 – Present) Kunming Institute of Zoology, Chinese Academy of Sciences
l Instructor (Dec 2010 – May 2012) Department of Developmental Biology, University of Texas Southwestern (UTSW) Medical Center, Dallas, TX, USA
Postdoctoral Researcher (2005 – 2010) Department of Developmental Biology, University of Texas Southwestern (UTSW) Medical Center, Dallas, TX, USA
Research Areas
The Tumor Signal Transduction Research Group employs an interdisciplinary approach, integrating evolutionary, developmental, and tumor biology. By leveraging big data mining across genomics, transcriptomics, and proteomics, we focus on identifying and characterizing the functional mechanisms of novel genes involved in tumorigenesis. Furthermore, we actively screen for potential anti-tumor lead compounds. Our ultimate goal is to develop innovative therapeutic strategies targeting hypoxic solid tumors.
Supported Projects
1. National Natural Science Foundation of China (NSFC) - Key Program, The function and mechanism of GLT8D1 inhibiting ferroptosis to promote tumor immune evasion, 2,610,000 RMB, 2023.01–2027.12
2. NSFC - Yunnan Joint Fund, The function and mechanism of GLT8D1 affecting glioma stem cell activity and tumor progression via the CD133/Wnt/β-catenin axis, 2,330,000 RMB, 2022.01–2025.12
3. NSFC - General Program, The function and mechanism of condensin complex subunit NCAPH in the development and progression of colorectal cancer, 550,000 RMB, 2018.01–2021.12
4. Chinese Academy of Sciences (CAS), Research Instrument and Equipment Development Project: Large field-of-view optical tomography microscopic imaging system for biological tissues, 3,000,000 RMB, 2020.01–2021.12
5. "Xingdian Talent Support Program", Yunling Scholar Project: Spatiotemporal dynamics of the tumor hypoxic microenvironment and tumor heterogeneity, 5,000,000 RMB, 2024.01–2028.12
6. Yunnan Provincial Basic Research Program - Major Project, Common mechanisms underlying convergent evolutionary adaptation to extreme environments and the formation of solid tumor heterogeneity, 3,000,000 RMB, 2024.03–2027.02
7. Yunnan Provincial Applied Basic Research Program - Key Project, Screening and functional mechanism study of candidate genes for convergent evolutionary adaptation in high-altitude animals, 500,000 RMB, 2020.06–2023.05
Awards and Honors
1. Outstanding Professional and Technical Talent with Prominent Contributions, People's Government of Yunnan Province, 2024
2. 2022 STTT Annual Best Paper Award, Signal Transduction and Targeted Therapy, 2022
3. 2022 STTT Outstanding Reviewer Award, Signal Transduction and Targeted Therapy, 2022
4. Grand Prize of Yunnan Provincial Science and Technology Progress Award, People's Government of Yunnan Province, 2020
5. Second Prize of Yunnan Provincial Science and Technology Progress Award, People's Government of Yunnan Province, 2020
6. Leading Talent in Scientific and Technological Innovation, National High-level Personnel of Special Support Program (Organization Department of the CPC Central Committee), 2019
7. Industrial Technology Leading Talent, Yunnan Provincial High-level Talent Training and Support Program (Yunnan Provincial Development and Reform Commission), 2018
8. Young and Middle-aged Leading Scientist in Scientific and Technological Innovation, Ministry of Science and Technology of the People's Republic of China, 2016
9. First Prize of Yunnan Provincial Science and Technology Progress Award, People's Government of Yunnan Province, 2015
10. 7th Yunnan Provincial Youth Science and Technology Award, Department of Human Resources and Social Security of Yunnan Province & Yunnan Association for Science and Technology, 2015
11. High-End Scientific and Technological Talent of Yunnan Province, Department of Science and Technology of Yunnan Province, 2014
12. Excellent Young Scientists Fund, National Natural Science Foundation of China (NSFC), 2013
13. Youth Program, National Overseas High-Level Talent Introduction Plan (Organization Department of the CPC Central Committee), 2012
14. Overseas High-Level Talent Introduction Program, Chinese Academy of Sciences (CAS), 2012
Overseas High-Level Talent of Yunnan Province, Organization Department of Yunnan Provincial Committee, 2012
Publications
1. Yulin Shi#, Baiyang Liu#, Yong Zhang#, Sen Zhao#, Li Zuo, Jun Pu, Haoqing Zhai, Dengcai Mu, Jia Du, Yan Cheng*, Cuiping Yang*,Yongbin Chen*.YTHDF1/RNF7/p27 axis promotes prostate cancer progression.Cell Death & Disease.2025 Apr 18;16(1):314
2. Qiushuo Shen#, Yanfei Han#, Kai Wu#, Yaomei He, Xiulin Jiang, Peishen Liu, Cuifeng Xia, Qiuxia Xiong,Rui liu, Qianming Chen, Yong Zhang, Song Zhao*, Cuiping Yang*,Yongbin Chen*.MrgprF acts as a tumor suppressor in cutaneous melanoma by restraining PI3K/Akt signaling .Signal Transduction and Targeted Therapy.2022 May 4;7(1):147
3. Kun Liu#,Liping Jiang#, Yulin Shi,Baiyang Liu,Yaomei He, Qiushuo Shen,Xiulin Jiang,Zhi Nie,Jun Pu,Cuiping Yang，Yongbin Chen*.Hypoxia-induced GLT8D1 promotes glioma stem cell maintenance by inhibiting CD133 degradation through N-linked glycosylation.Cell Death and Differentiation.2022 Sep;29(9):1834-1849
4. Yaomei He#, Xiulin Jiang#, Lincan Duan#, Qiuxia Xiong, Yixiao Yuan, Peishen Liu, Liping Jiang, Qiushuo Shen, Song Zhao, Cuiping Yang*，Yongbin Chen*.LncRNA PKMYT1AR promotes cancer stem cell maintenance in non-small cell lung cancer via activating Wnt signaling pathway.Molecular Cancer.2021 Dec 2;20(1):156
5. Qiuxia Xiong#, Liping Jiang#, Kun Liu#, Xiulin Jiang, Baiyang Liu, Yulin Shi, Dating Cheng, Yong Duan*, Cuiping Yang*, Yongbin Chen*.miR-133b targets NCAPH to promote β-catenin degradation and reduce cancer stem cell maintenance in non-small cell lung cancer.Signal Transduction and Targeted Therapy.2021 Jul 7;6(1):252
6. Xiulin Jiang#, Baiyang Liu#, Zhi Nie, Lincan Duan, Qiuxia Xiong, Zhixian Jin, Cuiping Yang*，Yongbin Chen*.The role of m6A modification in the biological functions and diseases.Signal Transduction and Targeted Therapy.2021 Feb 21;6(1):74.
7. Peifang Xu#, Liping Jiang#, Yang Yang#, Mengge Wu, Baiyang Liu, Yulin Shi, Qiushuo Shen, Xiulin Jiang, Yaomei He, Dating Cheng, Qiuxia Xiong, Zuozhang Yang, Lincan Duan, Jie Lin, Song Zhao, Peng Shi, Cuiping Yang*, Yongbin Chen*.PAQR4 promotes chemoresistance in non-small cell lung cancer through inhibiting Nrf2 protein degradation.Theranostics.2020 Feb 19;10(8):3767-3778
8. Yulin Shi#, Songqing Fan#, Mengge Wu#, Zhixiang Zuo, Xingyang Li, Liping Jiang, Qiushuo Shen, Peifang Xu, Lin Zeng, Yongchun Zhou, Yunchao Huang, Zuozhang Yang, Jumin Zhou,Jing Gao, Hu Zhou, Shuhua Xu, Hongbin Ji, Peng Shi, Dongdong Wu*, Cuiping Yang*, Yongbin Chen*.YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression.Nature Communications. 2019 Oct 25;10(1):4892
9. Baiyang Liu #, Xudong Xiang #, Yan Cheng #, Jimin Fei #, Mengge Wu, Laihao Qu, Xian Zhao, Xing Chen, Yao Li, Jia Du, Dengcai Mu, Haoqing Zhai, Qiushuo Shen *, Yongbin Chen *, Cuiping Yang *. NCAPH promotes immune evasion via inhibiting PD-L1 protein degradation in head and neck squamous cell carcinoma. Cancer letters. 2025 Dec 11:639:218218. doi: 10.1016/j.canlet.2025.218218.
10. Dongming Xu#, Cuiping Yang#, Qiushuo Shen#, Shengkai Pan#,Zhen Liu#, Tongzuo Zhang#, Xin Zhou, Menglong Lei， Peng Chen，Hui Yang, Tao Zhang,Yuanting Guo, Xiangjiang Zhan*, Yongbin Chen*, Peng Shi*.A single mutation underlying phenotypic convergence for hypoxia adaptation on the Qinghai-Tibetan Plateau.Cell Research.2021 Sep;31(9):1032-1035.
Collaborations and Networks
University of Texas Southwestern (UTSW) Medical Center, Dallas, TX, USA: Supported by the National Natural Science Foundation for International Cooperation to foster mutual research exchange.
Member
CHEN YONGBIN Research Professor
