In 2004, Graduated from Shandong University, College of Life Science, Bachelor of Science degree;

In 2010, Graduated from Kunming Institute of Zoology, Chinese Academy of Sciences, animal science PhD.

1). Demographic history of domestic dogs.

As the first domesticated animal and man’s closest friend, domestic dog (canis familiaris) has followed human beings and travelled across a wide variety of ecological niches with us. The main interest is to draw a picture of where, when, and how the domestic dog originated, and understand the migration history of dogs. The lab will use the ancient and modern genomics of domestic dogs and their wild relatives to study the above questions.

2). Decipher the genetics of dog behavior

Domestic dogs have special skills in comprehending human communicative behaviors, which have evolved as a result of domestication. The goal of this part is to understand the genetic basis of dog behavior, and mental diseases shared with humans, like obsessive-compulsive disorder, depression and autism. The study will shed light on the genetic architecture of these disorders in humans.

3). Dogs as bio-medical model

Due to the convergent evolution of genes related to nervous system function between dogs and humans, the similarities in brain action and gene network between dogs and humans, and the common health risk factors between dogs and humans, dogs have become an excellent large animal model for mental disorders and aging. Our lab uses the beagles as an animal model to decipher the cell biological mechanism based on single-cell sequencing technology, and to explore the mechanism of aging through stem cell intervention.

The fourth batch of National "Ten Thousand Talents Plan" Young Top Talents (2019)；

Excellent member of Youth Promotion Association of Chinese Academy of Sciences (2019)；

Young and middle-aged Academic and technical leaders of Yunnan Province (2019)；

2021 Excellent Reviewer of China Association for Science and Technology.

1.         Zhou QJ, Liu XY, Zhang LL, Wang R, Yin TT, Li XL, Li GM, He YQ, Ding ZL, Ma PC, Wang SZ, Mao BY, Zhang SH, Wang GD. A single-nucleus transcriptomic atlas of the dog hippocampus reveals the potential relationship between specific cell types and domestication. National Science Review, 2022, nwac147.

2.         Wang GD, Zhang SR, Li XY, Mesenchymal stem cell Culture Medium and Culture Method from dog umbilical Cord. Application/Grant No. : 202010976166.2

3.         Zhang SJ, Wang GD, Ma PC, Zhang LL, Yin TT, Liu YH, Otecko NO, Wang M, Ma YP, Wang L, Mao B, Savolainen P, Zhang YP. Genomic regions under selection in the feralization of the dingoes. Nature Communications, 2020, 11: 671.

4.         Jagannathan V, Hitte C, Kidd JM, Masterson P, Murphy TD, Emery S, Davis B, Buckley RM, Liu YH, Zhang XQ, Leeb T, Zhang YP, Ostrander EA, Wang GD. Dog10K_Boxer_Tasha_1.0: A Long-Read Assembly of the Dog Reference Genome. Genes-Basel 2021; 12.

5.         Li JX, Huang QG, Wang SZ, Zhou QJ, Gao X, Zhang YP, Wang GD. Behavioral evidence for the origin of Chinese Kunming dog. Curr Zool 2021; 67: 469-471.

6.         Wu CI, Wang GD, Xu SH. Convergent adaptive evolution-how common, or how rare? National Science Review 2020; 7: 945-946.

7.         Wang XC, Feng H, Chang YX, Ma CL, Wang LY, Hao XY, Li AL, Cheng H, Wang L, Cui P, Jin JQ, Wang XB, Wei K, Ai C, Zhao S, Wu ZC, Li YY, Liu BY, Wang GD, Chen L, Ruan J, Yan YJ. Population sequencing enhances understanding of tea plant evolution. Nature Communications 2020.

8.         Ghanatsaman, AZ, Wang, GD, Nanaei AH, Fozi AM, Peng MS, Esmailizadeh A and Zhang YP. Whole genome resequencing of the Iranian native dogs and wolves to unravel variome during dog domesticatio. BMC Genomics, 2020, 21:207.

9.         Cao X, Liu WP, Cheng LG, Li HJ, Wu H, Liu YH, Chen C, Xiao X, Li M, Wang GD, and Zhang YP. 2020. Whole genome analyses reveal significant convergence in obsessive-compulsive disorder between humans and dogs. Sci. Bull.

10.     Liu YH, Wang L, Zhang Z, Otecko NO, Khederzadeh S, Dai Y, Liang B, Wang GD, Zhang YP. Whole-Genome Sequencing Reveals Lactase Persistence Adaptation in European Dogs. Mol Biol Evol 2021; 38: 4884-4890.

11.     Zhang M, Sun G, Ren L, Yuan H, Dong G, Zhang L, Liu F, Cao P, Ko AM, Yang MA, Hu S, Wang GD, Fu Q. 2020. Ancient DNA evidence from China reveals the expansion of Pacific dogs. Mol Biol Evol msz311.

12.     Tang B, Zhou Q, Dong L, Li W, Zhang X, Lan L, Zhai S, Xiao J, Zhang Z, Bao Y, Zhang YP, Wang GD, Zhao W. iDog: an integrated resource for domestic dogs and wild canids. Nucleic Acids Res 2019, 47 (D1), D793-D800.

13.     Wang GD, Shao XJ, Bai B, Wang J, Wang X, Cao X, Liu YH, Wang X, Yin TT, Zhang SJ, Lu Y, Wang Z, Wang L, Zhao W, Zhang B, Ruan J, Zhang YP. Structural variation during dog domestication: insights from gray wolf and dhole genomes. National Science Review, 2019, 6: 110-122.

14.     Wang GD, Larson G, Kidd JM, vonHoldt BM, Ostrander EA, Zhang YP, Dog10K: the International Consortium of Canine Genome Sequencing. Natl Sci Rev 2019, 6 (4), 611-613.

1.      National Key Research and Development Program "Transformative Technology Key Scientific Issues" -- Using the domestic dog as a model to analyze the biological basis of social interaction and Emotion

2.      Science and Technology Innovation 2030- "Brain Science and Brain-like Research" Major Project

3.      General Project: Phylogeny of Canidae and Evolutionary Mechanism of Plateau Adaptation in Qinghai-Tibet Plateau

4.      2020-2022 Innovation Teams-Canine Human Disease Innovation Team, Kunming Institute of Zoology, Chinese Academy of Sciences

5.      Spring City Plan High-level Innovation and Entrepreneurship Team Project