The paleogenomes and human genetic diversity. Ancient DNA (aDNA) is among one of the most advanced hotspot research areas in recent years, which possesses active vitality and broad application prospects. aDNA technology provided the revolutionary changes in novel genome research era and the reconstruction of past human population histories become feasible. With application of aDNA technology, we are engaged in studying the human paleogenomes in East Asia, under integrated with modern human genomes big datasets, we are aiming to reveal the early human settlement, migration, cultural & gene exchange and admixture histories from Paleolithic age to present, as well as the genetic mechanism of human environmental adaptation in the process.

Population histories and biogeography of large mammals based on ancient and modern animal populations genomes. I have been engaged in animal genetic studies in my master degree training stage. Now, using the aDNA technology application, we also focus on studying the animal paleogenomes (e.g, large mammals), to explore the spatial-temporal distribution, pre-historical migration and gene flow among different species, as well as their interaction with paleo-climate, paleo-ecology and early human activity.

a)    National Outstanding Youth in Natural Science (2022)

b)   Yunnan Provincial Youth Top Talent (2019)

c)    Yunnan provincial excellent doctoral thesis (2016)

d)   The Excellence Award of the Chinese Academy of Sciences, China (2014)

e)    Outstanding graduates of the Chinese Academy of Sciences, China (2014)

f)    Pacesetter to Merit Student, Chinese Academy of Sciences, China (2014)

g)   National Scholarship for Ph. D student, Ministry of Education, China (2013)

1)      Xiaoming Zhang, Xueping Ji, Chunmei Li, Tingyu Yang, Jiahui Huang, Yinhui Zhao, Yun Wu, Shiwu Ma, Yuhong Pang, Yanyi Huang, Yaoxi He, and Bing Su 2022. A Late Pleistocene human genome from Southwest China. Current Biology, 32, 1–15.

2)      Xiaoming Zhang, Qi Liu, Hui Zhang, Shilei Zhao, Jiahui Huang, Tuot Sovannary, Long Bunnath, Hong Seang Aun, Ham Samnom, Bing Su, Hua Chen (2021). The distinct morphological phenotypes of Southeast Asian aborigines are shaped by novel mechanisms for adaptation to tropical rainforest. National Science Review, 9(3): 1-11.

3)      Ningbo Chen, Lele Ren, Linyao Du, Jiawen Hou, Victoria E. Mullin, Duo Wu, Xueye Zhao, Chunmei Li, Jiahui Huang, Xuebin Qi, Marco Rosario Capodiferro, Alessandro Achilli, Chuzhao Lei, Fahu Chen, Bing Su, Guanghui Dong and Xiaoming Zhang (2020). Ancient genomic DNA evidence reveals the presence of tropical bovid species in northeastern Tibetan Plateau contributed to the prevalence of hunting games until the late Neolithic. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 117 (45): 28150-28159.

4)      Zhang XM, Qi XB, Yang ZH, Serey, B Sovannary, T Bunnath, L, H Seang Aun, H Samnom, Zhang H, Lin Q, M Van Oven, Shi H. & Su B 2013. Analysis of Mitochondrial Genome Diversity Identifies New and Ancient Maternal Lineages in Cambodian Aborigines. Nature Communications 4, 2599.

5)      Xiaoming Zhang, Chunmei Li; Yanan Zhou, Jiahui Huang, Tengsong Yu, Xu Liu, Hong Shi, Hong Liu, Stephen Chia, Shenmin Huang, Yaozheng Guo, Rasmi Shoocongdej, Xueping Ji and Bing Su 2020. A Matrilineal Genetic Perspective of Hanging Coffin Custom in Southern China and Northern Thailand, iScience, 23, 101032.

6)      Zhang XM, Liao SY, Qi XB, Liu JW, Kampuansai J, Zhang H, Yang Z, Serey B, Sovannary T, Bunnath L, Seang Aun H, Samnom H, Kangwanpong D, Shi H, Su B 2015. Y-chromosome diversity suggests southern origin and Paleolithic backwave migration of Austro-Asiatic speakers from eastern Asia to the Indian subcontinent. Scientific Reports 5: 15486.

7)      Qi XB, Cui CY, Peng Y, Zhang XM, Yang ZH, Zhong H, Zhang H, Xiang K, Cao XY, Wang Y, Ouzhuluobu, Basang, Ciwangsangbu, Bianba, Gonggalanzi, Wu TY, Chen H, Shi H. & Su B 2013. Genetic Evidence of Paleolithic Colonization and Neolithic Expansion of Modern Humans on the Tibetan Plateau. Molecular Biology and Evolution. 30, 1761-1778.

8)      Yang, Zhaohui; Zhong, Hua; Chen, Jing; Zhang, Xiaoming; Zhang, Hui; Luo, Xin; Xu, Shuhua; Chen, Hua; Lu, Dongsheng; Han, Yinglun; Li, Jinkun; Fu, Lijie; Qi, Xuebin; Peng, Yi; Xiang, Kun; Lin, Qiang; Guo, Yan; Li, Ming; Cao, Xiangyu; Zhang, Yanfeng; Liao, Shiyu; Peng, Yingmei; Zhang, Lin; Guo, Xiaosen; Dong, Shanshan; Liang, Fan; Wang, Jun; Willden, Andrew; Aun, Hong Seang; Serey, Bun; Sovannary, Tuot; Bunnath, Long; Samnom, Ham; Mardon, Graeme; Li, Qingwei; Meng, Anming; Shi, Hong; Su, Bing 2016. A Genetic Mechanism for Convergent Skin Lightening during Recent Human Evolution, Molecular Biology and Evolution. 33(5), 1177-1187.

9)      Zhang XM, Jatupol K, Qi XB, Yan S, Yang ZH, Bun S, Tuot S, Long B, Hong SA, Ham S, Luo X, Liao SY, Daoroong K, Jin L, Shi H. & Su B (2014). An updated phylogeny of the human Y-chromosome lineage O2a-M95 with novel SNPs. Plos One 9 e101020.

10) Sushil Bhandari, Xiaoming Zhang, Chaoying Cui, Bianba, Shiyu Liao, Yi Peng, Hui Zhang, Kun Xiang, Hong Shi, Ouzhuluobu, Baimakongzhuo, Gonggalanzi, Shimin Liu, Gengdeng, Tianyi Wu, Xuebin Qi & Bing Su 2015. Genetic evidence of a recent Tibetan ancestry to Sherpas in the Himalayan region. Scientific Reports 5: 16249. 10.1038/srep16249.

11) Sushil Bhandari, Xiaoming Zhang, Chaoying Cui, Yangla, Lan Liu, Ouzhuluobu, Baimakangzhuo, Gonggalanzi, Caijuan Bai, Bianba, Yi Peng, Hui Zhang, Kun Xiang, Hong Shi, Shiming Liu, Gengdeng, Tianyi Wu, Xuebin Qi & Bing Su 2017. Sherpas share genetic variations with Tibetans for highaltitude adaptation. Molecular Genetics & Genomic Medicine. 5(1): 76–84.

12) Li R, Zhang XM, Campana MG, Huang JP, Chang ZH, Qi XB, Shi H, Su B, Zhang RF, Lan, XY, Chen H. & Lei CZ 2017. Paternal Origins of Chinese Cattle. Animal Genetics. 44, 446-449.

13)  Yang Z, Bai C, Pu Y, Kong Q, Guo Y; Ouzhuluobu; Gengdeng; Liu X, Zhao Q, Qiu Z, Zheng W, He Y, Lin Y, Deng L, Zhang C, Xu S, Peng Y, Xiang K, Zhang X; Baimayangji; Cirenyangji; Cui C; Baimakangzhuo; Gonggalanzi; Bianba; Pan Y, Xin J, Wang Y, Liu S, Wang L, Guo H, Feng Z, Wang S, Shi H, Jiang B, Wu T, Qi X, Su B 2022. Genetic adaptation of skin pigmentation in highland Tibetans. Proceedings of the National Academy of Sciences of the United States of America (PNAS). 119(40).

14)  Xiang K, Ouzhuluobu, Peng Y, Yang ZH, Zhang XM, Cui CY, Zhang H, Li M,   Zhang Y, Bianba, Gonggalanzi, Basang, Ciwangsangbu, Wu TY, Chen H, Shi H, Qi XB. & Su B. Identification of a Tibetan-Specific Mutation in the Hypoxic Gene EGLN1 and Its Contribution to High-Altitude Adaptation. Molecular Biology and Evolution. 30, 1889-1898, (2013).

15)  Yang Z, Shi H, Ma P, Zhao S, Kong Q, Bian T, Gong C, Zhao Q, Liu Y, Qi X, Zhang X, Han Y, Liu J, Li Q, Chen H, Su B 2018. Darwinian Positive Selection on the Pleiotropic Effects of KITLG Explain Skin Pigmentation and Winter Temperature Adaptation in Eurasians. Molecular Biology and Evolution. 35(9):2272-2283.

a)    National key research and development plan project (2023-2025)

b)    National Natural Science Outstanding Youth Foundation (2023-2025)

c)    Yunnan Province Revitalizing Yunnan Youth Talent Program (2020-2024)

d)    National Natural Science Foundation, General project (2019-2022)