(*Corresponding authors) 1.Lu G, Zhou QX, Kang S, Zhao LC, Chen JD, Sun JF, Cao J, Wang YJ, Chen J, Chen XY, Zhong DF, Chi ZQ, Li QL, Xu L*, and Liu JG* (2010) Chronic morphine treatment impairs hippocampal LTP and spatial memory via accumulation of extracellular adenosine acting on adenosine A1 receptors. J Neurosci 30(14):5058-5070. 2.Dai JX, Han HL, Tian M, Cao J, Xiu JB, Song NN, Huang Y, Xu TL, Ding YQ*, and Xu L* (2008) Enhanced contextual fear memory in central serotonin-deficient mice. Proc Natl Acad Sci USA 105:11981-11986. 3.Li HB, Mao RR, Zhang JC, Yang Y, Cao J, and Xu L* (2008) Antistress effect of TRPV1 channel on synaptic plasticity and spatial memory. Biol Psychiatry 64:286-292. 4.Yang Y, Zheng X, Wang Y, Cao J, Dong Z, Cai J, Sui N*, and Xu L* (2004) Stress enables synaptic depression in CA1 synapses by acute and chronic morphine: possible mechanisms for corticosterone on opiate addiction. J Neurosci 24:2412-2420. 5.Rowan MJ*, Anwyl R, and Xu L (1998) Stress and long-term synaptic depression. Mol Psychiatry 3:472-474. 6.Xu L, Holscher C, Anwyl R, and Rowan MJ* (1998) Glucocorticoid receptor and protein/RNA synthesis-dependent mechanisms underlie the control of synaptic plasticity by stress. Proc Natl Acad Sci U S A 95:3204-3208. 7.Xu L, Anwyl R, and Rowan MJ* (1998) Spatial exploration induces a persistent reversal of long-term potentiation in rat hippocampus. Nature 394:891-894. 8.Xu L, Anwyl R, and Rowan MJ* (1997) Behavioural stress facilitates the induction of long-term depression in the hippocampus. Nature 387:497-500. Recent Publications (2007-2011) 1.Tian M, Mao RR, Wang LP, Zhou QX, Cao J, Xu L. Interaction between behavioral despair and addictive behaviors in rats. Physiol Behav 2011;102(1):7-12. 2.Cheng YQ, Xu J, Chai P et al. Brain volume alteration and the correlations with the clinical characteristics in drug-naive first-episode MDD patients: a voxel-based morphometry study. Neurosci Lett 2010;480(1):30-34. 3.Dong Z, Han H, Cao J, Xu L. Opioid withdrawal for 4 days prevents synaptic depression induced by low dose of morphine or naloxone in rat hippocampal CA1 area in vivo. Hippocampus 2010;20(2):335-343. 4.Lu G, Zhou QX, Kang S et al. Chronic morphine treatment impaired hippocampal long-term potentiation and spatial memory via accumulation of extracellular adenosine acting on adenosine A1 receptors. J Neurosci 2010;30(14):5058-5070. 5.Wen F, Xu L. Effects of isolation after sexual experience on anxiety-like, depressive-like behaviors and affective states in male rats. Chinese Science Bulletin 2010;55:4136-4142. 6.Xu J, Cheng Y, Chai P et al. White-matter volume reduction and the protective effect of immunosuppressive therapy in systemic lupus erythematosus patients with normal appearance by conventional magnetic resonance imaging. J Rheumatol 2010;37(5):974-986. 7.Yang T, Cheng Y, Li H et al. Abnormal regional homogeneity of drug-naive obsessive-compulsive patients. Neuroreport 2010;21(11):786-790. 8.Zhou QX, Mao RR, Duan TT et al. Stress within the postseizure time window inhibits seizure recurrence. Epilepsy Behav 2010;18(3):201-206. 9.Zhao L, Zhu Y, Wang D, Chen M, Gao P, Xiao W, Rao G, Wang X, Jin H, Xu L, Sui N, Chen Q. Morphine induces Beclin 1- and ATG5-dependent autophagy in human neuroblastoma SH-SY5Y cells and in the rat hippocampus. Autophagy 2010;6:386-394. 10.Bai HY, Cao J, Liu N, Xu L, Luo JH. Sexual behavior modulates contextual fear memory through dopamine D1/D5 receptors. Hippocampus 2009;19(3):289-298. 11.Mao RR, Tian M, Yang YX, Zhou QX, Xu L, Cao J. Effects of pentylenetetrazol-induced brief convulsive seizures on spatial memory and fear memory. Epilepsy Behav 2009;15(4):441-444. 12.Hao YH, Yan Q, Liu HH, Xu L, Xue ZM, Song XQ, Kaneko Y, Jiang TZ, Liu ZN, Shan BC. Schizophrenia patients and their healthy siblings share disruption of white matter integrity in the left prefrontal cortex and the hippocampus but not the anterior cingulate cortex. Schizophrenia Research 2009;114: 128-135 13.Liu HH, Hao YH, Kaneko Y, Ouyang X, Zhang Y, Xu L, Xue ZM, Liu ZN. Frontal and cingulate gray matter volume reduction in heroin dependence: Optimized voxel-based morphometry. Psychiatry and Clinical Neurosciences 2009;63: 563-568 14.Wang K, Yu C, Xu L, Qin W, Li K, Jiang T. Offline memory reprocessing: involvement of the brain's default network in spontaneous thought processes. PLoS One 2009;4: e4867 15.Dai JX, Han HL, Tian M et al. Enhanced contextual fear memory in central serotonin-deficient mice. Proc Natl Acad Sci U S A 2008;105(33):11981-11986. 16.Dong Z, Han H, Cao J, Zhang X, Xu L. Coincident activity of converging pathways enables simultaneous long-term potentiation and long-term depression in hippocampal CA1 network in vivo. PLoS ONE 2008;3(8):e2848. 17.Dong Z, Zhong W, Tian M et al. Morphine withdrawal affects both delayed-escape behaviour in Morris water maze and hippocampal NR2A/2B expression ratio. Brain Res 2008;1207:164-173. 18.Li HB, Mao RR, Zhang JC, Yang Y, Cao J, Xu L. Antistress effect of TRPV1 channel on synaptic plasticity and spatial memory. Biol Psychiatry 2008;64(4):286-292. 19.Liu H, Li L, Hao Y et al. Disrupted White Matter Integrity in Heroin Dependence: A Controlled Study Utilizing Diffusion Tensor Imaging. Am J Drug Alcohol Abuse 2008;1. 20.Gao Y, Han H, Xu R, Cao J, Luo J, Xu L. Effects of prolonged exposure to context following contextual fear conditioning on synaptic properties in rat hippocampal slices. Neurosci Res 2008;61(4):385-389. 21.Xu L. [Neural plasticity mechanism of depression]. Zhong Nan Da Xue Xue Bao Yi Xue Ban 2008;33(4):326-330. 22.Zhang LH, Gong N, Fei D, Xu L, Xu TL. Glycine uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition. Neuropsychopharmacology 2008;33(3):701-711. 23.Zhang Z, Gong N, Wang W, Xu L, Xu TL. Bell-shaped D-serine actions on hippocampal long-term depression and spatial memory retrieval. Cereb Cortex 2008;18(10):2391-2401. 24.Duan B, Wu LJ, Yu YQ et al. Upregulation of acid-sensing ion channel ASIC1a in spinal dorsal horn neurons contributes to inflammatory pain hypersensitivity. J Neurosci 2007;27(41):11139-11148. 25.Dong Z, Cao J, Xu L. Opiate withdrawal modifies synaptic plasticity in subicular-nucleus accumbens pathway in vivo. Neuroscience 2007;144(3):845-854. 26.Li L, Ma N, Li Z et al. Prefrontal white matter abnormalities in young adult with major depressive disorder: A diffusion tensor imaging study. Brain Res 2007;1168:124-128. 27.Ma N, Li L, Shu N et al. White matter abnormalities in first-episode, treatment-naive young adults with major depressive disorder. Am J Psychiatry 2007;164(5):823-826. 28.Ma WP, Cao J, Tian M et al. Exposure to chronic constant light impairs spatial memory and influences long-term depression in rats. Neurosci Res 2007;59(2):224-230. 29.Yang J, Hou C, Ma N et al. Enriched environment treatment restores impaired hippocampal synaptic plasticity and cognitive deficits induced by prenatal chronic stress. Neurobiol Learn Mem 2007;87(2):257-263. Patents 1.the application of 5-methyl-1,3-benzenediol or derivatives thereof in the preparation of medicines and functional foods for treatment or prevention of depression, PPNO:PCT/CN2008/071752 2.Magnetic stimulation electrocircuit of central nervous system and its device, application and using method (International application number PCT/CN2006/001289 ) 3.N-Substituted-4-Substituted phenyl-5-Alkyl-5-Substituted benzyl pyrrolidone-2, its intermediate, synthetic method and application(Xiaojing Hao, Xiaosheng Yang, Jun Zhou, Jingxia Cai, Lin Xu, Xintian Hu: Patent Number ZL 94 1 04879.9)
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