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Principal Investigator
Details of the Faculty or Staff
Name  
 Yongbin Chen
Title  
   Deputy Director of the Academic Committee of the Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences
Highest Education 
   Doctor of Philosophy
Address  
 No. 17 Longxin Road, Panlong District, Kunming City, Yunnan Province, China.
Phone  
   +86 0871-65176320
Zip Code  
   650201
Fax  
   +86 871 65176312
E-mail  
   ybchen@mail.kiz.ac.cn

Education and Appointments：

In 2000, Yongbin Chen obtained a Bachelor of Science degree from Wuhan University, China, and his major focused on virology; in 2005, Yongbin Chen obtained a Doctor of Science degree from the Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences; from 2005 to 2010, Dr. Chen worked as a postdoctoral researcher in the Department of Developmental Biology at the University of Texas Southwestern Medical Center at Dallas, USA.

From December 2010 to May 2012, Dr. Chen worked as an Instructor in the Department of Developmental Biology at the University of Texas Southwestern Medical Center in the United States. In May 2012, Dr. Chen was recruited as a Principal Investigator/Professor at the Kunming Institute of Zoology, Chinese Academy of Sciences.

Research Interests：

Identifying molecular events involved in high-altitude hypoxia adaptation and hypoxic solid tumors.

During 4.7 billion years of Earth's history, diverse and adaptable species have evolved to survive in different vital environments, including hypoxia, extreme cold, and intense UV radiation conditions. A deep understanding of the molecular evolutionary mechanisms underlying these personalized adaptive traits is critical for deciphering the molecular events governing human life processes and different types of human diseases, including tumors. Biomarkers for hypoxic solid tumors are traditionally identified by comparing cancerous with paracancerous tissues using comprehensive integrative analyses. Burrowing rodents like naked and blind mole rats living under extremely hypoxic conditions evolve strong hypoxic tolerance and cancer resistance and could reveal molecular events important for cancer progression, suggesting that we can use evolutionary theory to identify genes involved in both hypoxia adaptation and hypoxic solid tumors. Our studies represent the application of evolutionary theory, using genomic and transcriptome data from hypoxia-adapted Tibet domestic mammals, to identify a ranked list of genes that can form the basis for not only hypoxia adaptation of species to high elevations, but also have a broad impact in cancer biology and therapy. Therefore, we advocate for the requirement of evolutionary methods and concepts to understand cancer progression and the hallmarks of cancer from a different angle.
Public Services：

Honors：

Recipient of the Special Prize for Science and Technology Progress of Yunnan Province (2020), the First Prize for Science and Technology Progress of Yunnan Province (2015), and the Second Prize for Science and Technology Progress of Yunnan Province (2020), as well as the 7th Yunnan Provincial Youth Science and Technology Award (2015). Dr. Chen was also awarded by the STTT Outstanding Reviewer Award in 2022 and the Excellent Reviewer Award for Biotechnology Bulletin in 2019.

 

Dr. Chen was selected for the National Special Support Program for High-level Talents in Science and Technology Innovation in 2019, the Young and Middle-aged Science and Technology Leading Talents Program of the Ministry of Science and Technology in 2016, Outstanding Youth of National Nature Science Foundation of China in 2014, the National Young Overseas High-level Talents Introduction Plan and the Chinese Academy of Sciences in 2012; the Industry Technology Leading Talents Special Project of Yunnan Province's High-level Talents Training Support Program in 2018; the Yunnan Provincial High-end Science and Technology Talents in 2014, and the Yunnan Provincial Overseas High-level Talents in 2012.

Selected Publication：

1. Shen QS, Han YF, Wu K, He YM, Jiang XL, Liu PS, Xia CF, Xiong QX, Liu R, Chen QM, Zhang Y, Zhao S, Yang CP, Chen YB. 2022. MrgprF acts as a tumor suppressor in cutaneous melanoma by restraining PI3K/Akt signaling. Signal Transduction and Targeted Therapy, 7(1).

2. Lin J, Liu BY, Zhang Y, Lv L, Cheng DT, Zhang WH, Shi YL, Jiang XL, Tang L, Yuan YX, Zhai HQ, Shen QS, Xiong QX, Jin ZX, Chen YB, Yang CP. 2022. Gemin6 promotes c‐Myc stabilisation and non‐small cell lung cancer progression via accelerating AURKB mRNA maturation. Clinical and Translational Medicine, 12(4).

3. Liu K, Jiang LP, Shi YL, Liu BY, He YM, Shen QS, Jiang XL, Nie Z, Pu J, Yang CP, Chen YB. 2022. Hypoxia-induced GLT8D1 promotes glioma stem cell maintenance by inhibiting CD133 degradation through N-linked glycosylation. Cell Death & Differentiation, 29(9): 1834-1849.

4. He YM, Jiang XL, Duan LC, Xiong QX, Yuan YX, Liu PS, Jiang LP, Shen QS, Zhao S, Yang CP, Chen YB. 2021. LncRNA PKMYT1AR promotes cancer stem cell maintenance in non-small cell lung cancer via activating Wnt signaling pathway. Molecular cancer, 20(1): 1-21.

5. Xiong QX, Jiang LP, Liu K, Jiang XL, Liu BY, Shi YL, Cheng DT, Duan Y, Yang CP, Chen YB. 2021. miR-133b targets NCAPH to promote β-catenin degradation and reduce cancer stem cell maintenance in non-small cell lung cancer. Signal Transduction and Targeted Therapy, 6(1): 252.

6. Xu DM, Yang CP, Shen QS, Pan SK, Liu Z, Zhang TZ, Zhou X, Lei ML, Chen P, Yang H, Zhang T, Guo YT, Zhan XJ, Chen YB, Shi P. 2021. A single mutation underlying phenotypic convergence for hypoxia adaptation on the Qinghai-Tibetan Plateau. Cell Research, 31(9): 1032-1035.

7. Jiang XL, Liu BY, Nie Z, Duan LC, Xiong QX, Jin ZX, Yang CP, Chen YB. 2021. The role of m6A modification in the biological functions and diseases. Signal Transduction and Targeted Therapy, 6(1): 74.

8. Xu PF, Jiang LP, Yang Y, Wu MG, Liu BY, Shi YL, Shen QS, Jiang XL, He YM, Cheng DT, Xiong QX, Yang ZZ, Duan LC, Lin J, Zhao S, Shi P, Yang CP, Chen YB. 2020. PAQR4 promotes chemoresistance in non-small cell lung cancer through inhibiting Nrf2 protein degradation. Theranostics, 10(8): 3767.

9. Wu DD, Yang CP, Wang MS, Dong KZ, Yan DW, Hao ZQ, Fan SQ, Chu SZ, Shen QS, Jiang LP, Li Y, Zeng L, Liu HQ, Xie HB, Ma YF, Kong XY, Yang SL, Dong XX, Esmailizadeh A, Irwin DM, Xiao X, Li M, Dong Y, Wang W, Shi P, Li HP, Ma YH, Gou X, Chen YB, Zhang YP. 2020. Convergent genomic signatures of high-altitude adaptation among domestic mammals. National Science Review, 7(6): 952-963.

10. Shi YL, Fan SQ, Wu MG, Zuo ZX, Li XY, Jiang LP, Shen QS, Xu PF, Zeng L, Zhou YC, Huang YC, Yang ZZ, Zhou JM, Gao J, Zhou H, Xu SH, Ji HB, Shi P, Wu DD, Yang CP, Chen YB. 2019. YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression. Nature Communications, 10(1): 4892.

11. Yang CP, Li XY, Wu Y, Shen QS, Zeng Y, Xiong QX, Wei MP, Chen CH, Liu JW, Huo YX, Li KQ, Xue G, Yao YG, Zhang C, Li M, Chen YB, Luo XJ. 2018. Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes. Nature Communications, 9(1): 838.

12. Li QG, He YH, Wu H, Yang CP, Pu SY, Fan SQ, Jiang LP, Shen QS, Wang XX, Chen XQ, Yu Q, Li Y, Sun C, Wang XT, Zhou JM, Li HP, Chen YB, Kong QP. 2017. A normalization-free and nonparametric method sharpens large-scale transcriptome analysis and reveals common gene alteration patterns in cancers. Theranostics, 7(11): 2888.

13. Yu L, Wang GD, Ruan J, Chen YB, Yang CP, Cao X, Wu H, Liu YH, Du ZL, Wang XP, Yang J, Cheng SC, Zhong L, Wang L, Wang X, Hu JY, Fang L, Bai B, Wang KL, Yuan N, Wu SF, Li BG, Zhang JG, Yang YQ, Zhang CL, Long YC, Li HS, Yang JY, Irwin DM, Ryder OA, Li Y, Wu CI, Zhang YP. 2016. Genomic analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to high-altitude adaptation. Nature Genetics, 48(8): 947-952.

14. Ren FF, Shi Q, Chen YB, Jiang A, Ip YT, Jiang HQ, Jiang J. 2013. Drosophila Myc integrates multiple signaling pathways to regulate intestinal stem cell proliferation during midgut regeneration. Cell Research, 23(9): 1133-1146.

15. Chen YB, Jiang J. 2013. Decoding the phosphorylation code in Hedgehog signal transduction. Cell Research, 23(2): 186-200.

Supported Projects：

The functional and mechanistic study of GLT8D1 in inhibiting ferroptosis and promoting tumor immune escape (NSFC Key Project); The functional and mechanistic study of GLT8D1 in regulating glioblastoma stem cell activity and tumor progression via the CD133/Wnt/β-catenin axis (NSFC-Yunnan Joint Fund); Preclinical study of targeted drug lercanidipine for the treatment of glioblastoma (Yunnan Major Science and Technology Special Project for Biomedicine); Screening and mechanistic study of candidate genes for convergent evolution adaptation in high-altitude animals (Yunnan Applied Basic Research Key Project).
 
 
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