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Current Directors
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Principal Investigator
Details of the Faculty or Staff
Name  
Yonghan He
Title  
 
Highest Education 
  Doctor of Medicine
Address  
No.17 Longxin Road, Kunming 650201, Yunnan, China
Phone  
  +86-871-65118976
Zip Code  
  650201
Fax  
  
E-mail  
  heyonghan@mail.kiz.ac.cn

Education and Appointments:

Education

·Doctor of Medicine in Public Health College, Harbin Medical University, from Sep., 2007 to Dec., 2012.

·China-Canada Joint training PhD in National Research Council of Canada (NRC), from Sep., 2011 to Sep., 2012.

·Bachelor of Science (Honors) in Preventive Medicine in Harbin Medical University, from Sep., 2002 to July, 2007.

Professional Appointment

·Professor in Center for Evolutionary Development Research, Kunming Institute of Zoology, Chinese Academy of Sciences. From Oct., 2020 to Present.

·Post-doctoral Associate in University of Florida (UF), USA. From June 2018 to Sep., 2020.

·Post-doctoral fellow in University of Arkansas for Medical University (UAMS), USA. From Oct., 2016 to May, 2018.     

·Associate Professor in Kunming Institute of Zoology, Chinese Academy of Sciences, From Jan., 2015 to Sep., 2016.

·Assistant Professor in Kunming Institute of Zoology, Chinese Academy of Sciences, From Jan., 2013 to Dec., 2014.


Research Interests:

Aging is an extremely complex biological trait and an important risk factor for aging-related diseases. The research direction and content of our group are focused on:

·Aging regulation: Using multi-omics tools, we analyze the regulatory networks of aging in animals and humans from genetic and evolutionary perspectives, and identify the regulatory factors of aging and unique biological traits (such as tumor resistance, extreme environmental adaptation, etc.);

·Aging targets: Using biological models of aging (nematodes, fruit flies, mice or primates, etc.) to tap into intervention targets for aging and related traits and to develop effective interventions;

·Cellular senescence and small-molecule drug development: We use model organisms and aging systems of human cells to study in vivo and vitro intervention strategies targeting senescent cells, providing theoretical and applied basis for anti-aging and extending a healthy lifespan.

Public Services:

Honors:

·Awarded for achievements in research presentations at the 61st Annual Meeting of the American Society of Hematology (2019).

·Member of Young Innovation Promotion Association of Chinese Academy of Sciences (2016).

·University's first prize in Science and Technology of Heilongjiang Province (2013). 

·Second place in the Heilongjiang Province Science and Technology Progress Award (2013). 

 


Selected Publication:

Journal Article:

[1]     Huang YQ#, Ge MX#, Li YH#, Li JL, Yu Q, Xiao FH, Ao HS, Yang LQ, Li J*, He YH*, Kong QP*. 2022. Longevity-associated transcription factor ATF7 promotes healthspan by suppressing cellular senescence and systematic inflammation. Aging and disease, 1-16.

[2]     Ge MX, Hu L, Ao HS, Zi MT, Kong QP*, He YH*. 2021. Senolytic targets and new strategies for clearing senescent cells. Mechanisms of Ageing and Development, 195, 111468.

[3]     He YH#, Zhang X(uan)#, Chang JH#, Kim H#, Zhang PY, Wang YY, Khan S, Liu XG, Zhang X(in), Lv DW, Li W, Thummuri D, Yuan YX, Elisseeff J, Campisi J, Almeida M, Song L, Zheng GR*, Zhou DH*. 2020. Using Proteolysis-Targeting Chimera Technology to Reduce Navitoclax Platelet Toxicity and Improve Its Senolytic Activity. Nature Communications, 11(1), 1996.

[4]     He YH, Koch R, Budamagunta V, Zhang PY, Zhang X(uan), Khan S, Thummuri D, Ortiz Y. T, Zhang X(in), Lv DW, Wiegand J. S, Li W, Palmer A. C, Zheng GR, Weinstock D. M*, Zhou DH*. 2020. DT2216–a Bcl-xL specific degrader is highly active against Bcl-xL-dependent T-cell lymphomas. Journal of Hematology & Oncolog, 13(1), 95.

[5]     He YH, Wen Li, Lv DW, Zhang Xin, Zhang X, Campisi Judith, Zheng GR, Zhou DH*. 2020. Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity. Aging Cell, 19(3), 13117.

[6]     He YH#, Khan S#, Huo ZG, Lv DW, Zhang X, Liu XG, Yuan YX, Hromas R, Xu MJ, Zheng GR, Zhou DH. 2020. Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies. Journal of Hematology & Oncology, 13(1), 103.

[7]     Khan S#, He YH#, Zhang X, Yuan YX, Pu SY, Kong QP, Zheng GR, Zhou DH*. 2020. PROteolysis TArgeting Chimeras (PROTACs) as emerging anticancer therapeutics. Oncogene, 39(26), 4909-4924.

[8]     Zhang X#, He YH#, Zhang PY#, Budamagunta V, Lv DW, Thummuri D, Yang Y, Pei J, Yuan YX, Zhou DH*, Zheng GR*. 2020. Discovery of IAP-Recruiting BCL-XL PROTACs as Potent Degraders across Multiple Cancer Cell Lines. European Journal of Medicinal Chemistry, 199, 112397.

[9]   Khan Sajid#, Zhang X#, Lv DW#, Zhang Q, He YH, Zhang PY, Yuan YX, Liu XG, Thummuri Dinesh, Wiegand Janet, Ferrando Adolfo, Hromas Robert, Konopleva Maria, Zheng GR*, Zhou DH*. 2019. A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity. Nature Medicine, 25(12), 1938-1947.

[10] He YH, Thummuri D, Zheng GR, Okunieff P, Citrin DE, Vujaskovic Z, Zhou DH*. 2019. Cellular Senescence and Radiation-induced Pulmonary Fibrosis. Translational Research, 209, 14-21.

[11] Li W#, Qin L#, Feng RN, Hu GR, Sun H, He YH*, RP Zhang*. 2019. Emerging senolytic agents derived from natural products. Mechanisms of Ageing and Development, 181, 1-6.

[12] Xiao FH#, Chen XQ#, Yu Q#, Ye YS#, Liu YW, Yan DJ, Yang LQ, Chen GJ, Lin R, Yang LP, Liao XP, Zhang W, Zhang W, Wang XF, Zhou JM*, Cai WW*, He YH*, Kong QP*. 2018. Transcriptome evidence reveals enhanced autophagy-lysosomal function in centenarians. Genome Research, 28(11), 1601-1610.

[13] Li QG#, He YH#, Wu H#, Yang CP, Pu SY, Fan SQ, Jiang LP, Shen QS, Wang XX, Chen XQ, Yu Q, Li Y, Sun C, Wang XT, Zhou JM, Li HP, Chen YB*, Kong QP*. 2017. A normalization-free and nonparametric method sharpens pan-cancer expression analysis. Theranostics, 7(11), 2888-2899.

[14] He YH#, Chen XQ#, Yan DJ, Xiao FH, Lin R, Liao XP, Liu YW, Pu SY, Yu Q, Sun HP, Jiang JJ, Cai WW*, Kong QP*. 2016. Familial longevity study reveals a significant association of mitochondrial DNA copy number between centenarians and their offspring. Neurobiology of Aging, 47, 218-11.

[15] Xiao FH, Kong QP, Perry B, He YH*. 2016. Progress on the role of DNA methylation in aging and longevity. Briefings in Functional Genomics, 15(6), 454-459.

Book chapter

[1]     He YH, Zheng GR, Zhou DH. 2020. Senolytic Drug Development. In: Senolytics in Disease, Ageing and Longevity. Healthy Ageing and Longevity. Springer, Cham, 11, 222.

Patent

[1]     Guangrong Zheng; Daohong Zhou; Xuan Zhang; Sajid Khan; Yonghan He; Peiyi Zhang; Bcl-2 proteins degraders for cancer treatment, 2019-01-22, 3088253.

[2]     Daohong Zhou; Guangrong Zheng; Yonghan He; Liya Pi; Methods of treating diseases associated with senescent cell accumulation, 2021-10-12, 507145165.


Supported Projects:

National Natural Science Foundation (NSFC) of China:

·The role and mechanism of senescent cell-specific highly expressed lncRNA-PURPL in regulating aging, Jan., 2022 - Dec., 2025.

·The role and mechanism of longevity population-specific low-expressed gene, thyroxine transporter protein MCT10, in regulating aging, Jan., 2017 - Dec., 2020.

·The role of heat shock protein 70 (HSP-70) in obesity development, Jan., 2016 - Dec., 2018.

Projects of the Chinese Academy of Sciences:

·Pioneer Hundred Talents Program - Youth Project (Category B), Jan., 2022 - Dec., 2024.

·Strategic Pioneering Science and Technology Special Project (Category A) "Pan-Third Pole Environmental Change and Green Silk Road Construction" subproject, March, 2018 - Feb., 2023.

Yunnan Provincial Applied Basic Research Program:

·The role and mechanism of p53-related long chain non-coding RNA-LINC01021 in regulating aging, June, 2022 - May, 2025.

·The role and mechanism of thyroxine monocarboxylate transporter protein 10 in affecting aging/longevity, June, 2017 - May, 2020.

·Screening and functional study of DNA methylation regulatory loci associated with longevity in the Chinese population, Oct., 2013 - Sep, 2016.

 
 
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