Scientists
Education and Appointments
Education
Doctor of Philosophy (Ph.D.)
Kunming Institute of Zoology, Chinese Academy of Sciences
Sep. 2013 – Jan. 2020
Bachelor of Science
Northeast Agricultural University
Sep. 2009 – Jul. 2013
Professional Experience
Feb. 2020 – Apr. 2020
Assistant Researcher
State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences
Apr. 2020 – Dec. 2023
Associate Researcher
State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences
Jan. 2024 – Present
Researcher / Principal Investigator
State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences
Research Areas
Employing multi-omics technologies to elucidate key cell fates in primate neurogenesis, and integrating lineage tracing to reveal stem cell dynamics as well as neurogenic patterns. 2. Utilizing clinical samples, brain organoids, and transgenic monkey models to investigate the pathogenic mechanisms of rare neurodevelopmental disorders, such as Fragile X Syndrome. 3. Integrating primate ENCODE data with artificial intelligence models to develop enhancer-driven, cell-specific gene therapy tools.
Supported Projects
1. National Science Fund for Excellent Young Scholars (2025–2027), Principal Investigator
2. Yunnan Provincial Fundamental Research Program - Key Project (2025–2028), Principal Investigator
3. Yunnan Provincial Xingdian Talents Support Program - Young Talents (2023–2027), Principal Investigator
4. National Natural Science Foundation of China - General Program (2022–2025), Principal Investigator
5. National Science and Technology Innovation 2030 - "Brain Science and Brain-Like Intelligence Technology" Major Project (2021–2026), Key Member / Core Participant
6. Member of the Youth Innovation Promotion Association, Chinese Academy of Sciences (2021–2024), Principal Investigator
Awards and Honors
Awardee of the NSFC Excellent Young Scholars Fund(2025)
Publications
1.Luo X, Liu Y, Dang D, Hu T, Hou Y, Meng X, Zhang F, Li T, Wang C, Li M, Wu H, Shen Q, Hu Y, Zeng X, He X, Yan L, Zhang S, Li C, Su B. (2021). 3D Genome of macaque fetal brain reveals evolutionary innovations during primate corticogenesis. Cell 184:723-740.e21. https://doi.org/10.1016/j.cell.2021.01.001
2.Luo X, He YX, Zhang C, He XC, Yan LZ, Li M, Hu T, Hu Y, Jiang J, Meng XY, Ji WZ, Zhao XD, Zheng P, Xu SH, Su B. (2019). Trio deep-sequencing does not reveal unexpected off-target and on-target mutations in Cas9-edited rhesus monkeys. Nature Communications 10:5525. https://doi.org/10.1038/s41467-019-13481-y
3.Shi L, Luo X, Jiang J, Chen YC, Liu CR, Hu T, Li M, Lin Q, Li YJ, Huang J, Wang H, Niu YY, Shi YD, Styner M, Wang JH, Lu Y, Sun XJ, Yu HL, Ji WZ, Su B. (2019). Transgenic rhesus monkeys carrying the human MCPH1 gene copies show human-like neoteny of brain development. National Science Review 6: 480-493. https://doi.org/10.1093/nsr/nwz043
4.He YX, Luo X, Zhou B, Hu T, Meng XY, Audano PA, Kronenberg ZN, Eichler EE, Jin J, Guo YB, Yang YN, Qi XB, Su B. (2019). Long-read assembly of the Chinese rhesus macaque genome and identification of ape-specific structural variants. Nature Communications 10:4233. https://doi.org/10.1038/s41467-019-12174-w
Member
Zejia Cui Postdoctoral Fellow
Xiaoxia Yang Research Assistant
Jingchen Xie Class of 2025, Master's Student
