Evidence of AS3MTd2d3-Associated Variants within 10q24.32-33 in the Genetic Risk of Major Affective Disorders. Mol Neuropsychiatry. 2017, 2(4):213-218 Title: Evidence of AS3MTd2d3-Associated Variants within 10q24.32-33 in the Genetic Risk of Major Affective Disorders. Author: Li L, Chang H, Peng T, Li M, Xiao X Publication Name: Mol Neuropsychiatry Pub Year: 2017 Volume: 2 Issue: 4 Page Number: 213-218 IF: 7.739 Abstract: Genome-wide association studies suggest that 10q24.32-33 is a risk region for schizophrenia (SCZ). Considering the substantialgenetic overlap between SCZ and major affective disorders, we would like to investigate whether the 10q24.32-33 region confers riskof affective disorders. We chose three SCZ genome-wide significant SNPs (rs7914558, rs7085104, and rs11191580) in 10q24.32-33and collected the statistical data from European and Asian populations to perform systematic meta-analyses, which finally included up to 26,413 cases with affective disorders and 24,849 controls. Meta-analyses showed that all SNPs were nominally associated withmajor affective disorders. Considering the a priori evidence that these SNPs were associated with the expression of AS3MTd2d3isoform in the human brain, our data confirms the potential involvement of AS3MTd2d3 in the genetic risk of major affective disorders. |
