During the past decade, genetic studies ofschizophreniahave become one of the most exciting and fast-moving areas. Hundreds of genes implicated inschizophreniahave been identified by genetic, epigenetic, and gene expression studies. However, how to systematically and efficiently use these published data to pinpoint the causal genes becomes a major challenge inschizophreniaresearch. Here, we releaseanupdatedversion of acomprehensivedatabaseforschizophreniaresearch,SZDB2.0(), which accompanies significant data expansion and feature improvements, as well as functionality optimization. Compared with the first version (SZDB), the current database has the following updates: (1) We added the newly published genome-wide association study (GWAS) ofschizophreniafrom CLOZUK + PGC, which is the largest GWASforschizophrenia; (2) We included a polygenic risk score calculator; (3) In the refined "Gene" module ofSZDB2.0, we collated genetic, gene expression, methylation, and integrative results of all availableschizophreniastudies; (4) In the "CNV (copy number variation)" module, we collated the results of all 77 CNV publications aboutschizophrenia; (5) We alsoupdatedother data, including gene expression quantitative trait loci (eQTL), transcript QTL, methylation QTL, and protein-protein interaction data, based on the information from the latest literatures. We optimized the query interface ofSZDB2.0fora better visualization and data retrieval. TheupdatedSZDB2.0will advance theresearchofschizophrenia.