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Scientists Found A New Glioblastoma Classification Method
Heterogeneity is a basic characteristic of cancer , including intra-tumor heterogeneity and heterogeneity among patients mainly due to a variety of genetic alterations .CAS ) and Columbia University recently found a new method for GBM based on the genetic alterations of CDKN2A and TP53 genes with mutation rates of 60% and 30% respectively .Additionally , the activation of RAS pathway plus Cdkn2... more
Molecular mechanism of tree shrew’s insensitivity to spiciness
Spicy foods elicit a pungent or hot and painful sensation that repels almost all mammals .Prof . LAI Ren ’ group from Kunming Institute of Zoology , Chinese Academy of Sciences and researchers from Zhejiang University observed that tree shrews ( Tupaia belangeri chinensis ) , which possess a close relationship with primates .Can directly and actively consume chili peppers , despite the deep ge... more
Pore-forming protein initiates scar-less healing
Tissue repair is a common problem during animal survival .However , scar tissue formation is a common by-product of human wound healing , which can lead to severe clinical dysfunction .Therefore , how to promote tissue regeneration and repair while reducing scar formation is an important issue .Compared with epidermal growth factor ( EGF ) widely used in clinic , this complex can not only promo... more
Salivary Factor from Aedes aegypti Facilitates Zika Virus Transmission
Identified in the 1940s in Africa , Zika is primarily spread by the bite of an infected mosquito .JIN Lin , GUO Xiaomin , SHEN chuanbin , HAO Xue ( Kunming Institute of Zoology , CAS ) and SUN Peng ( Tsinghua University ) are the co-first authors of this paper .CHENG Gong ( Tsinghua University ) , QI Xiaopeng and LAI Ren ( Kunming Institute of Zoology , CAS ) are the corresponding authors . ? ... more
How centipedes slay giant prey
Centipede rapidly subdues Kunming mouseThis study uncovers the molecular mode of action of centipede venom , which helps the tiny creatures subdue larger-bodied prey .Structural and functional analysis of this interaction revealed that two specific interacting residue pairs ( K13 - D266 and R12 - D288 ) are crucial to the toxin ' s effect on KCNQ4 . ? ? In vivo tests further revealed that SsT... more
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