Speaker：Jiliang Zhou (Department of Pharmacology and Toxicology in Medical College of Georgia, Georgia Regents University) 

Title： Role of Hippo-YAP signaling in smooth muscle phenotypic modulation and development  

Time and Venue: 10-July-2014; 16:00; 

KIZ main building, 3nd floor conference room 237 

Dr. Zhou is an Associate Professor at Department of Pharmacology and Toxicology in Medical College of Georgia, Georgia Regents University. Research at Dr. Zhou’s laboratory focuses on smooth muscle phenotypic switch and development. Particularly, his group is studying the role of Hippo-YAP signaling in vascular smooth muscle cells by utilizing a variety of approaches including transgenic and tissue specific knock-out mice. His group has published many high quality papers in the journals such as Circ. Res., ATVB and JBC.  

Website of Dr. Zhou’s lab: http://www.gru.edu/mcg/phmtox/phtx_faculty_zhou.php  

Papers:  

　　Wang Y., Hu G., Liu F., Wang X., Wu M., Schwarz J., Zhou J.*. Deletion of Yes-Associated Protein (YAP) specifically in cardiac and vascular smooth muscle cells reveals a crucial role for YAP in mouse cardiovascular development. Circulation Research, 2014, 114(6): 957-965. Cover Article and Editor’s Picks.  

　　Liu F., Wang X., Hu G., Wang Y., and Zhou J.*. The transcription factor TEAD1 represses smooth muscle-specific gene expression by abolishing myocardin function. J. Biol. Chem., 2014, 289(6): 3308-3316. Selected as a “Paper of the Week” with the criteria that ranked in the top 2 percent of manuscripts in a year in significance and overall importance by the editorial board members and associate editors.  

　　Wang, X., Hu, G., Gao, X., Wang, Y., Zhang, W., Harmon, E. Y., Zhi, X., Z. Xu, Lennartz, M. R., Barroso, M., Trebak, M., Chen, C., and Zhou, J.*. The induction of Yes-Associated Protein expression after arterial injury is crucial for smooth muscle phenotypic modulation and neointima formation. Arteriosclerosis, Thrombosis, and Vascular Biology, 2012, 32(11): 2662-2669.  

　　Wang X., Hu G., Courtney B.C., Harmon, E.Y., Keller R.S., Van De Water L., and Zhou J.*. Transforming Growth Factor-β1-induced Transcript 1 protein, a novel marker for smooth muscle contractile phenotype, is regulated by serum response factor/myocardin protein. J. Biol. Chem., 2011, 286(48): 41589-41599.  

　　Zhou, J.*, Hu, G., Wang X.. Repression of smooth muscle differentiation by a novel high-mobility-group box containing protein, HMG2L1. J. Biol. Chem., 2010, 285(30): 23177-23185. Wang, X., Hu, G., Zhou, J.*. Repression of versican expression by miR-143. J. Biol. Chem., 2010, 285(30): 23241-23250.  

　　 Laboratory of Oncobiology　 　 

State Key Laboratory of Genetic Resources and Evolution  

10.07.2014