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In Search of Biologically Active Chemical Probes and Potential Therapeutic Agents

Man Lun Richard Yip (葉文麟), Ph.D.

Phone: (Office) +1 (626) 256-4673, ext. 65057   (Mobile) +1 (626) 818-0311

Beckman Research Institute of the City of Hope

1710 E Flower Ave, Duarte CA 91010

Email: or


1988-95   Ph.D., Division of Biology

California Institute of Technology, Pasadena, California

Advisor: Howard D. Lipshitz, Ph.D.

1984-88   B.S., Biology and Chemistry (double majors)

Pacific Lutheran University, Tacoma, Washington 

Professional Experience
2006-     Director, High Throughput Screening Core

2006-     Associate Research Professor, Molecular Medicine

2008-09   Certificate, Clinical Investigation Training Program

Beckman Research Institute of the City of Hope, Duarte, California

2003-06   Staff Scientist, High Throughput Screening Core

Drug Discovery Program

H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida

2002-03   Division Head, Drug Discovery Cell Biology   

deCODE Genetics

Reykjavik, Iceland

2001-02   Senior Research Scientist

1999-01   Research Scientist

OSI Pharmaceuticals, Inc., Farmingdale, New York

1998-99   Senior Postdoctoral Fellow

1995-98   Postdoctoral Fellow

ABL-Basic Research Program

National Cancer Institute-Frederick Cancer Research and Development Center

Frederick, Maryland

Honors and Awards
1999 Fellows Award for Research Excellence, National Institute of Health

1988-93   Howard Hughes Medical Institute Predoctoral Fellowship

1988 Magna Cum Laude, Pacific Lutheran University

1987 Anders and Emma Ramstad Scholarship (Chemistry), Pacific Lutheran University

1987 Undergraduate Summer Research Fellowship, Yale University

1986 Undergraduate Summer Research Fellowship, University of Washington

Professional Memberships

American Association for Cancer Research

American Chemical Society

Society for Laboratory Automation and Screening

US Chinese Anti-Cancer Association

1.    Zhou BS, Su L, Hu S, Hu WD, Yip MLR, Wu J, Yuan YC, Synold TW, Horne D, Yen Y. A small-molecule compound interrupting ribonucleotide reductase holoenzyme formation inhibits cancer cell growth and overcomes drug resistance. Submitted.

2.    Sun G, Ye P, Gugiu G, Tsark W, Yuan X, Forman B, Yip MLR, Shi Y. Identification and characterization of novel ligands for orphan nuclear receptor TLX. Submitted.

3.    Yang F, Jove V, Chang S, Hedvat M, Liu L, Buettner R, Tian Y, Scuto A, Wen W, Yip MLR, Van Meter T, Yen Y, Jove R. Bortezomib induces apoptosis and growth suppression in human medulloblastoma cells, associated with inhibition of AKT and NF-ĸB signaling, and synergizes with an ERK inhibitor. Cancer Biol Ther. 13:349-357, 2012. PMID: 22406995.

4.    Kim J, Yip MLR, Shen X, Li H, Hsin L-YC, Labarge S, Heinrich EL, Lee W, Lu J, and Vaidehi N. Identification of Novel Antagonists to Chemokine Receptor CXCR4 in Pancreatic Cancer Cells. PLoS ONE. 7(2): e31004, 2012. PMID: 22319600.

5.    Gao J, Wang Y, Xing Q, Yan J, Senthil M, Akmal Y, Kowolik CM, Kang J, Lu DM, Zhao M, Lin ZX, Cheng CHK, Yip MLR, Yim JH. Identification of a Natural Compound by Cell-Based Screening that Enhances Interferon Regulatory Factor-1 Activity and Causes Tumor Suppression. Mol Cancer Ther. 10:1774-83, 2011. PMID: 21817116.

6.    Buettner R, Corzano R, Rashid R, Lin J, Senthil M, Hedvat M, Schroeder A, Mao A, Herrmann A, Yim J, Li H, Yuan YC, Yakushijin K, Yakushijin F, Vaidehi N, Moore R, Gugiu G, Lee TD, Yip R, Chen Y, Jove R, Horne D, Williams JC. Alkylation of cysteine 468 in Stat3 defines a novel site for therapeutic development. ACS Chem Biol. 6:432-443, 2011. PMID: 21226522.

7.    Esworthy RS, Kim BW, Larson GP, Yip MLR, Smith DD, Li M, Chu FF. A colitis locus on chromosome 2 impacting the severity of early-onset disease in mice deficient in GPX1 and GPX2. Inflamm Bowel Dis. 17:1373-86, 2011. PMID: 20872835.

J Mol Graph Model. 28:347-56, 2009. PMID: 19781967.

9.    Lawrence HR, Li Z, Yip MLR, Sung SS, Lawrence NJ, McLaughlin ML, McManus GJ, Zaworotko MJ, Sebti SM, Chen J, Guida WC. Identification of a disruptor of the MDM2-p53 protein-protein interaction facilitated by high-throughput in silico docking. Bioorg Med Chem Lett. 19:3756-9, 2009. PMID: 19457663.

10.  Kazi A, Lawrence HR, Guida WC, McLaughlin ML, Springett GM, Berndt N, Yip RM, Sebti SM. Discovery of a novel proteasome inhibitor selective for cancer cells over non-transformed cells. Cell Cycle. 8:1940-51, 2009. PMID: 19471122.

11.  Lawrence HR, Pireddu R, Chen L, Luo Y, Sung SS, Szymanski AM, Yip MLR, Guida WC, Sebti SM, Wu J, Lawrence NJ. Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds. J Med Chem. 51:4948-56, 2008. PMID: 18680359.

12.  Siddiquee K, Zhang S, Guida WC, Blaskovich MA, Greedy B, Lawrence HR, Yip MLR, Jove R, McLaughlin M, Lawrence NJ, Sebti SM, Turkson J. Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc Natl Acad Sci U S A. 104:7391-6, 2007. PMID: 17463090.

13.  Chen L, Sung SS, Yip MLR, Lawrence HR, Ren Y, Guida WC, Sebti SM, Lawrence NJ, Wu J. Discovery of a Novel Shp2 Protein Tyrosine Phosphatase Inhibitor. Mol Pharmacol. 70:562-70, 2006. PMID: 16717135.

14.  Pickup AT, Lamka ML, Sun Q, Yip MLR and Lipshitz HD. Control of photoreceptor cell morphology, planar polarity and epithelial integrity during Drosophila eye development. Development 129:2247-58, 2002. PMID: 11959832.

15.  Matesic LE, Yip R, Reuss AE, Swing DA, O'Sullivan TN, Fletcher CF, Copeland NG, Jenkins NA. Mutations in Mlph, encoding a member of the Rab effector family, cause the melanosome transport defects observed in leaden mice. Proc. Natl. Acad. Sci. USA 98:10238-43, 2001. PMID: 11504925.

16.  Wilson SM, Yip R, Swing DA, O'Sullivan TN, Zhang Y, Novak EK, Swank RT, Russell LB, Copeland NG, Jenkins NA. A mutation in Rab27a causes the vesicle transport defects observed in ashen mice. Proc. Natl. Acad. Sci. USA  97:7933-8, 2000. PMID: 10859366.

17.  Yip MLR, Lamka ML, Lipshitz HD. Control of germ-band retraction in Drosophila by the zinc-finger protein HINDSIGHT. Development 124:2129-41, 1997. PMID: 9187140.

18.  Yip, MLR and Lipshitz, HD. The terminal gene hierarchy of Drosophila and the genetic control of tissue specification and morphogenesis. Pp. 83-146. In Advances in Developmental Biology, Vol. 4. (ed. P. Wassarman). Connecticut: JAI Press, 1996.

19.  Strecker TR, Yip MLR, Lipshitz HD. Genetic control of cell fate in the termini of the Drosophila embryo. Dev. Biol. 150:422-6, 1992. PMID: 1551484.

20.  Strecker TR, Yip MLR, Lipshitz HD. Zygotic genes that mediate torso receptor tyrosine kinase functions in the Drosophila melanogaster embryo. Proc. Natl. Acad. Sci. USA  88:5824-8, 1991. PMID: 1905816.

21.  Clark MW, Yip MLR, Campbell J, Abelson J. SSB-1 of the yeast Saccharomyces cerevisiae is a nucleolar-specific, silver-binding protein that is associated with the snR10 and snR11 small nuclear RNAs. J Cell Biol. 111:1741-51, 1990. PMID: 2121740.

22.  Akaboshi E, Yip MLR, Howard-Flanders P. Nucleotide sequence of the recA gene of Proteus mirabilis. Nucleic Acids Res. 17:4390, 1989. PMID: 2544862.

Turkson J, Sebti SM, Guida WC, Yip ML, Lawrence NJ, Lawrence HR, Greedy B. “Small Molecule Inhibitors of STAT3 with Anti-Tumor Activity.” US Patent 7,960,434, June 14 2011.


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