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It is now widely recognized that the Native Americans, also called Indigenous Americans, reached the Americas from Asia as early as the Last Glacial Maximum (LGM; 26500-19000 years ago). Previous studies suggested the ancestors of Native Americans primarily came from Siberia. Now researchers led by Prof. KONG Qing-Peng from Kunming Institute of Zoology disclosed an additional ancestral sou... more |
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Increasing evidence suggests that interspecific hybridization is crucial to speciation. However, chromatin incompatibility during interspecific hybridization often renders this process. Genomic imbalances such as chromosomal DNA loss and rearrangements leading to infertility have been commonly noted in hybrids. The mechanism underlying reproductive isolation of interspecific hybridization ... more |
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Major depressive disorder (MDD) is the leading cause of disability worldwide and is expected to become the leading cause of the global disease burden by 2030. The "monoamine hypothesis of depression" suggests that monoamine deficiency is an important factor in the development of depression, therefore, the pharmacological mechanism of current first-line antidepressants is mainly to inhibit ... more |
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A research lab led by Prof. ZHENG Ping from Kunming Institute of Zoology of the Chinese Academy of Sciences has identified a p53-independent quality control factor which favors the rapid shutdown of the regulatory circuitry of pluripotency at the post-transcriptional levels, thereby ensuring robust differentiation and apoptosis in response to unrepaired DNA damage.
ESCs hold wide appli... more |
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A research lab led by Dr. ZENG Jianxiong from Kunming Institute of Zoology of the Chinese Academy of Sciences, in collaboration with Prof. ZHAO Zhen from Keck School of Medicine, University of Southern California, have discovered the cGAS-STING pathway-mediated innate immune mechanism underlying the development and progression of neurodegenerative Alzheimer's disease (AD).
AD mainly oc... more |
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