Title: The Regulations of Cylindromatosis (CYLD) on the Ciliogenesis of Mammals

Speaker: Prof ZHOU Jun (Nankai University)

Time: August 15 2015, Saturday, 10am

Venue: KIZ main building, third floor, conference room 327

Recent Publication:

　　1. Yang Y, Ran J, Sun L, Sun X, Luo Y, Yan B, Tala, Liu M, Li D, Zhang L, Bao G, Zhou J. (2015). CYLD regulates noscapine activity in acute lymphoblastic leukemia via a microtubule-dependent mechanism. Theranostics 5(7):656-666. 

　　2. Yang Y, Liu M, Li D, Ran J, Gao J, Suo S, Sun SC, Zhou J. (2014). CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation. PNAS 111(6):2158-2163. 

　　3. Yang Y, Ran J, Liu M, Li D, Li Y, Shi X, Meng D, Pan J, Ou G, Aneja R, Sun SC, Zhou J. (2014). CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6. Cell Research 24(11):1342-1353. 

　　4. Liu M, Li D, Sun L, Chen J, Sun X, Zhang L, Huo L, Zhou J. (2014). Modulation of Eg5 activity contributes to mitotic spindle checkpoint activation and Tat-mediated apoptosis in CD4-positive T-lymphocytes. Journal of Pathology 233(2):138-147. 

　　5. Tala, Xie S, Sun X, Sun X, Ran J, Zhang L, Li D, Liu M, Bao G, Zhou J. (2014). Microtubule-associated protein Mdp3 promotes breast cancer growth and metastasis. Theranostics 4(10):1052-1061. 

　　6. Sun X, Li D, Yang Y, Ren Y, Li J, Wang Z, Dong B, Liu M, Zhou J. (2012). Microtubule-binding protein CLIP-170 is a mediator of paclitaxel sensitivity. Journal of Pathology 226(4):666-673. 

　　7. Huo L, Li D, Sun L, Liu M, Shi X, Sun X, Li J, Dong B, Dong X, Zhou J. (2011). Tat acetylation regulates its actions on microtubule dynamics and apoptosis in T lymphocytes. Journal of Pathology 223(1):28-36. 

　　8. Shi X, Sun X, Liu M, Li D, Aneja R, Zhou J. (2011). CEP70 protein interacts with γ–tubulin to localize at the centrosome and is critical for mitotic spindle assembly. Journal of Biological Chemistry 286(38):33401-33408.  

　　9. Huo L, Li D, Sun X, Shi X, Karna P, Yang W, Liu M, Qiao W, Aneja R, Zhou J. (2011). Regulation of Tat acetylation and transactivation activity by the microtubule-associated deacetylase HDAC6. Journal of Biological Chemistry 286(11):9280-9286. 

　　10. Sun L, Gao J, Huo L, Sun X, Shi X, Liu M, Li D, Zhang C, Zhou J. (2010). Tumor suppressor CYLD is a negative regulator of the mitotic kinase Aurora-B. Journal of Pathology 221(4):425-432. 

　　11. Gao J, Sun L, Huo L, Liu M, Li D, Zhou J. (2010). CYLD regulates angiogenesis by mediating vascular endothelial cell migration. Blood 115(20):4130-4137. 

　　12. Liu M, Wang X, Yang Y, Li D, Ren H, Zhu Q, Chen Q, Han S, Hao J, Zhou J. (2010). Ectopic expression of the microtubule-dependent motor protein Eg5 promotes pancreatic tumorigenesis. Journal of Pathology 221(2):221-228. 

　　13. Dong X, Liu F, Sun L, Liu M, Li D, Su D, Zhu Z, Dong JT, Fu L, Zhou J. (2010). Oncogenic function of microtubule end-binding protein 1 in breast cancer. Journal of Pathology 220(3):361-369. 

　　14. Wang H, Liu B, Zhang C, Peng G, Liu M, Li D, Gu F, Chen Q, Dong JT, Fu L, Zhou J. (2009). Parkin regulates paclitaxel sensitivity in breast cancer via a microtubule-dependent mechanism. Journal of Pathology 218(1):76-85. 

　　15. Sun L, Gao J, Dong X, Liu M, Li D, Shi X, Dong JT, Lu X, Liu C, Zhou J. (2008). EB1 promotes Aurora-B kinase activity through blocking its inactivation by protein phosphatase 2A. PNAS 105(20):7153-7158.  

　　16. Liu M, Aneja R, Sun X, Xie S, Wang H, Wu X, Dong JT, Li M, Joshi HC, Zhou J. (2008). Parkin regulates Eg5 expression by Hsp70 ubiquitination-dependent inactivation of c-Jun NH2-terminal kinase. Journal of Biological Chemistry 283(51):35783–35788. 

　　17. Gao J, Huo L, Sun X, Liu M, Li D, Dong JT, Zhou J. (2008). The tumor suppressor CYLD regulates microtubule dynamics and plays a role in cell migration. Journal of Biological Chemistry 283(14):8802-8809.