Topic: Brain development and mechanisms of genetic regulation

Speaker: Prof WU Qiang (Shanghai Center for Systems Biomedicine, Shanghai Jiaotong University)

Time: August 18 2015, Tuesday, 9:30am

Venue: KIZ main building, second floor, Conference room 237

Everyone is welcome!

Representative publications:

　　Li J, Shou J，Guo Y, Tang Y, Wu Y, Jia Z, Zhai Y, Chen Z, Xu Q, Wu, Q. (2015). Efficient inversions and duplications of mammalian regulatory DNA elements and gene clusters by CRISPR/Cas9. J. Mol. Cell. Biol. doi:10.1093 /jmcb /mjv016. Epub 2015 March 11

　　Jia Z, Guo Y, Tang Y, Xu Q, Li B, Wu Q.* (2014) Regulation of the protocadherin Celsr3 gene and its role in globus pallidus development and connectivity. Mol. Cell. Biol. 34: 3895-3910.

　　Wang Y., Huang H., Wu Q.* (2014) Characterization of the zebrafish Ugt repertoire reveals a new class of drug-metabolizing UDP glucuronosyltransferases. Mol. Pharmacol. 86: 62-75.

　　Suo L., Lu H., Ying G., Capecchi M.R., Wu, Q.* (2012) Protocadherin clusters and cell adhesion kinase regulate dendrite complexity through Rho GTPase. J. Mol. Cell. Biol.4: 362-376. Cover Article

　　Guo Y., Monahan K., Wu H., Varley KE., Gertz J., Li W., Myers RM., Maniatis T.*, Wu Q.* (2012) CTCF/Cohesin-mediated DNA Looping is required for protocadherin alpha promoter choice. Proc. Natl. Acad. Sci. 109:21081-21086.

　　Yang J., Cai L., Huang H., Liu B., Wu, Q.* (2012) Genetic variations and haplotype diversity of the UGT1 gene cluster in the Chinese population. PLoS One 7: e33988.

　　Li W., Ni G., Zhang P., Zhang Z., Li W., Wu, Q.* (2010). Characterization of E2F3a function in HepG2 liver cancer cells. J. Cell. Biochem. 111: 1244-1251.

　　Huang, HY; Wu, Q.* (2010). Cloning and comparative analyses of the zebrafish Ugt repertoire reveal Its evolutionary diversity. PLoS One 5:e9144.

　　Ying, G., Wu, S., Hou, R., Huang, W., Capecchi, M., Wu, Q.* (2009). Protocadherin Celsr3 is required for interneuron migration in the mouse forebrain. Molecular and Cellular Biology 29: 3045-3061.

　　Zou, C., Huang, W., Ying, G., and Wu, Q.* (2007). Sequence analysis and expression mapping of the rat clustered protocadherin gene repertoires. Neuroscience 144: 579-603.

　　Wu, S., Ying, G., Wu, Q., and Capecchi, M.R. (2007). Towards simpler and faster genome-wide mutagenesis in mice. Nature Genetics 39: 922-930.

　　Li, C. and Wu, Q.* (2007). Evolution of vertebrate multiple variable first exons and structural diversity of drug metabolizing enzymes. BMC Evolutionary Biology 7: 69.

　　Wu, Q.* (2005). Comparative genomics and diversifying selection of the clustered vertebrate protocadherin genes. Genetics 169:2179-2188.

　　Zhang, T., Haws, P., and Wu, Q.* (2004) Multiple variable first exons:a mechanism for cell- and tissue- specific gene regulation. Genome Research 14: 70-89.

　　Wu, Q., Zhang, T., Cheng, J.-F., Kim, Y., Grimwood, J., Schmutz, J., Dickson, M., Noonan, J.P., Zhang, M.Q., Myers, R.M., and Maniatis, T.(2001). Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. Genome Research 11: 389-404.

　　Wu, Q. and Maniatis, T. (2000). Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes. Proc Natl Acad Sci 97:3124-3129.

　　Wu, Q. and Maniatis, T. (1999) A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell 97:779-790.

　　Wu, Q. and Krainer, A.R. (1996) U1-mediated exon definition interactions between AT-AC and GT-AG introns. Science 274: 1005-1008.