Title：Cell signaling in development and regeneration
Time:July 06 (Thursday) 2017, 15:00pm
Venue: Conference room 327, 3rd floor, main building, KIZ main campus
Everyone is welcome!
Introduction of the speaker:
Jin Jiang, Ph.D, Professor. My lab has been studying cell-signaling mechanisms that govern embryonic development and adult tissue homeostasis. We are particularly interested in Hedgehog (Hh) signaling mechanism and its role in regulating cell growth and patterning formation. We also studythe newly emerged Hippo (Hpo) tumor suppressor pathway in the context of organ size control and stem cell regulation. In collaboration with Tony IP at University of Massachusetts Medical School, we have established Drosophila adult midgut as a model system to study tissue homeostasis and regeneration. We have identified several signaling pathways that control intestine stem cell (ISC) self-renewal and proliferation. In particular, we demonstrated that intestinal epithelium derived BMP controls ISC self-renewal by inhibiting Notch activity, thus establishing a new paradigm for studying stem cell niche and its regulation. Our current and future study further explores the molecular mechanisms underlying the regulation of these important signaling pathways and understand how these and other signaling pathways integrate to control organ development and regeneration.