Speaker: Prof. Qian Tao (The Chinese University of Hong Kong)
Title：The dark side of cell signaling dysregulation in human cancer
Time:July 14 (Friday) 2017, 09:00am
Venue: Conference room 327, 3rd Floor, KIZ main building
Everyone is welcome!
Introduction of the speaker:
Specialized Research Area(s): Epigenetics, epigenomics, tumor suppressor gene, CpG methylation, carcinoma, cancer
1.Li LL, Zhang Y, Fan YC, Sun K, Su XW, Du ZF, Tsao SW, Loh TKS, Sun H, Chan ATC, Zeng YX, Chan WY, Chan FKL, Tao Q. Characterization of the nasopharyngeal carcinoma methylome identifies aberrant disruption of key signaling pathways and methylated tumor suppressor genes. Epigenomics 2015; 7: 155-173.
2.2. Li LL, Ying JM, Tong X, Zhong L, Su XW, Xiang TX, Shu XS, Rong R, Xiong L, Li HY, Chan ATC, Ambinder RF, Guo YJ, Tao Q. Epigenetic identification of receptor tyrosine kinase-like orphan receptor 2 as a functional tumor suppressor inhibiting beta-catenin and akt signaling but frequently methylated in common carcinomas. Cellular and Molecular Life Sciences 2014; 71: 2179-2192.
3.Hu XT, Sui XB, Li LL, Huang XF, Rong R, Su XW, Shi QL, Mo LJ, Shu XS, Kuang YY, Tao Q*, He C*. Protocadherin 17 acts as a tumour suppressor inducing tumour cell apoptosis and autophagy, and is frequently methylated in gastric and colorectal cancers. Journal of Pathology 2013; 229: 62-73. (*Corresponding authors)
4.Wang SY, Cheng YD, Du W, Lu LN, Zhou L, Wang HT, Kang W, Li XX,Tao Q*, Sung JJY, Yu J*. Zinc-finger protein 545 is a novel tumour suppressor that acts by inhibiting ribosomal rna transcription in gastric cancer. Gut 2013; 62: 833-841
5.Li L, Ying J, Li H, Zhang Y, Shu X, Fan Y, Tan J, Cao Y, Tsao SW, Srivastava G, Chan ATC, Tao Q. The human cadherin 11 is a pro-apoptotic tumor suppressor modulating cell stemness through wnt/beta-catenin signaling and silenced in common carcinomas. Oncogene 2012; 31: 3901-3912.
6.Cheng YD, Geng H, Cheng SH, Liang P, Bai Y, Li JS, Srivastava G, Ng MHL, Fukagawa T, Wu XS, Chan ATC, Tao Q. Krab zinc finger protein znf382 is a proapoptotic tumor suppressor that represses multiple oncogenes and is commonly silenced in multiple carcinomas. Cancer Research 2010; 70: 6516-6526.
7.Yu J, Tao Q, Cheung KF, Jin H, Poon FF, Wang X, Li HY, Cheng YY, Rocken C, Ebert MPA, Chan ATC, Sung JJY. Epigenetic identification of ubiquitin carboxyl-terminal hydrolase l1 as a functional tumor suppressor and biomarker for hepatocellular carcinoma and other digestive tumors. Hepatology 2008; 48: 508-518.
8.Jin HC, Wang X, Ying JM, Wong AHY, Cui Y, Srivastava G, Shen ZY, Li EM, Zhang Q, Jin J, Kupzig S, Chan ATC, Cullen PJ, Tao Q. Epigenetic silencing of a ca2+-regulated ras gtpase-activating protein rasal defines a new mechanism of ras activation in human cancers. Proceedings of the National Academy of Sciences of the United States of America 2007; 104: 12353-12358.
9.Ying J, Li H, Seng TJ, Langford C, Srivastava G, Tsao SW, Putti T, Murray P, Chan ATC, Tao Q. Functional epigenetics identifies a protocadherin pcdh10 as a candidate tumor suppressor for nasopharyngeal, esophageal and multiple other carcinomas with frequent methylation. Oncogene 2006; 25: 1070-1080.
10.Ying JM, Srivastava G, Hsieh WS, Gao ZF, Murray P, Liao SK, Ambinder R, Tao Q. The stress-responsive gene gadd45g is a functional tumor suppressor, with its response to environmental stresses frequently disrupted epigenetically in multiple tumors. Clinical Cancer Research 2005; 11: 6442-6449.
11.Chan ATC#, Tao Q#, Robertson KD, Flinn IW, Mann RB, Klencke B, Kwan WH, Leung TWT, Johnson PJ, Ambinder RF. Azacitidine induces demethylation of the epstein-barr virus genome in tumors. Journal of Clinical Oncology 2004; 22: 1373-1381. (# Co-first author)
12.Tao Q, Huang H, Geiman TM, Lim CY, Fu L, Qiu GH, Robertson KD. Defective de novo methylation of viral and cellular DNA sequences in icf syndrome cells. Human Molecular Genetics 2002; 11: 2091-2102.