Speaker: Prof. Feng-Yuan Chen (Laboratory of Medical Genetics, Central South University, China)
Title：Endothelial progenitor cells and diabetic wound healing
Time: August 29 (Tuesday) 2017, 9:00am
Venue: Conference room 237, 2nd floor, main building, KIZ main campus
Everyone is welcome!
Selected publications of Prof. Chen
1. Wang JM, Tao J, Chen DD, Cai JJ, Irani K, Wang Q, Yuan H, Chen AF*. MicroRNA miR-27b rescues bone marrow-derived angiogenic cell function and accelerates wound healing in type 2 diabetes mellitus.Arterioscler Thromb Vasc Biol. 2014,34,99-109
2. Bae ON, Wang JM, Baek SH, Wang Q, Yuan H, Chen AF*. Oxidative stress-mediated thrombospondin-2 upregulation impairs bone marrow-derived angiogenic cell function in diabetes mellitus. Arterioscler Thromb Vasc Biol. 2013,33,1920-1927
3. Chen DD, Dong YG, Yuan H, Chen AF*.Endothelin 1 Activation of Endothelin A Receptor/ NADPH Oxidase Pathway and Diminished Antioxidants Critically Contribute to Endothelial Progenitor Cell Reduction and Dysfunction in Salt-Sensitive Hypertension. Hypertension 2012,59, 1037-1043
4. Marrotte EJ, Chen, DD, Hakim JS, Chen AF*. Restoration of endothelial progenitor cell function with manganese superoxide dismutase accelerates wound healing in type 2 diabetic mice. Journal of Clinical Investigation (JCI）2010,120,4207-4219
5. Xie HH, Zhou S, Chen DD, Channon KM, Su DF, Chen AF*. GTP cyclohydrolase I/BH4 pathway protects EPCs via suppressing oxidative stress and thrombospondin-1 in salt-sensitive. Hypertension 2010,56,1137-1144
6. Du YH, Chen, AF*. A new role for caveolin-1: regulation of GTP cyclohydrolase I and tetrahydrobiopterin in endothelial cells. Hypertension 2009,53, 115-117
7. Du YH, Guan YY, Alp NJ, Channon KM, Chen AF*. Endothelial-specific GTP cyclohydrolase I overexpression attenuates blood pressure progression in salt-sensitive low renin hypertension. Circulation2008,117, 1045-1154
8. Chen DD, Chen AF*. CuZn-SOD deficiency: a culprit of accelerated vascular aging process.Hypertension 2006,48, 1026-1028
9. Kidd, GA, Hong H, Majid A, Kaufman DI, Chen AF*. Inhibition of brain GTP cyclohydrolase I and tetrahydrobiopterin attenuates cerebral infarction via reducing iNOS and peroxynitrite in ischemic stroke. Stroke2005,36, 2705-2711
10. Luo JD, Wang YY, Fu WL, Wu J, Chen AF*. Gene therapy of eNOS and MnSOD accelerates delayed wound healing in type 1 diabetic mouse. Circulation 2004,110, 2484-2493
11. Li LX, Fink GD, Watts SW, Galligan JJ, Pagano PJ, Chen AF*. ET-1 increases vascular superoxide via ETA-NADPH oxidase pathway in low renin hypertension. Circulation 2003,107, 1053-1058
12. Li LX, Galligan JJ, Fink GD, Chen AF*. Vasopressin enhances vascular superoxide production by activating Endothelin-1 in mineralocorticoid hypertension. Hypertension 2003 ,41 [part 2], 663-668
13. Li LX, Watts SW, Galligan JJ, Fink GD, Chen AF*. NADPH oxidase-derived superoxide augments ET-1-induced venoconstriction in mineralocorticoid hypertension. Hypertension 2003,42, 316-321
14. Zheng JS, Yang XQ, Lookingland KJ, Fink GD, Hesslinger C, Kapatos G, Kovesdi I, Chen AF*. Gene transfer of human guanosine 5’-triphosphate cyclohydrolase I restores vascular tetrahydrobiopterin level and endothelial dysfunction in low renin hypertension. Circulation 2003,108, 1238-1245
15. Li LX, Chu Y, Fink GD, Engelhardt JF, Heistad DD, Chen AF*. ET-1 stimulates arterial VCAM-1 expression via superoxide in mineralocorticoid hypertension. Hypertension 2003,42, 997-1003
16. Li LX, Crockett E, Wang DH, Galligan JJ, Fink GD, Chen AF*. Gene transfer of endothelial NO synthase and manganese superoxide dismutase on arterial vascular cell adhesive molecule-1 expression and superoxide production in deoxycorticosterone acetate-salt hypertension. Arteriosclerosis Thrombosis and Vascular Biology2002,22, 249-255
Key Laboratory of Animal Models and Human Disease Mechanisms
Laboratory of Tumor Signal Transduction
Laboratory of Cancer Biology
08-15-2017
