Speaker: Prof. Hong-Bing Zhang (Institute of Basic Medical Sciences, Peking Union Medical College and Chinese Academy of Medical Sciences)　  　　

Title：mTOR signal transduction abnormal and tumor

Time: August 29 (Tuesday) 2017, 10:00am

Venue: Conference room 237, 2nd floor, main building, KIZ main campus

Everyone is welcome! 

　Key Laboratory of Animal Models and Human Disease Mechanisms 

　　Laboratory of Tumor Signal Transduction

Laboratory of Cancer Biology

08-15-2017

Selected publications of Prof. Zhang

1. Liu Z, Mao J, Wu X, Xu H, Wang X, Huang B, Zheng J, Nie M, Zhang H. Efficacy and Outcome Predictors of Gonadotropin Treatment for Male Congenital Hypogonadotropic Hypogonadism. Medicine 2016 Mar;95(9):e2867.
2. Chen X, Wang Y, Tao J, Shi Y, Gai X, Huang F, Ma Q, Zhou Z, Chen H, Zhang H, Liu Z, Sun Q, Peng H, Chen R, Jing Y, Yang H, Mao Y, Zhang H. mTORC1 Upregulates GP73 to Promote Proliferation and Migration of Hepatocellular Carcinoma Cells and Growth of Xenograft Tumors in Mice. Gastroenterology. 2015;149:741–752.e14
3. Hu Z, Wang Y, Huang F, Chen R, Li C, Wang F, Goto J, Kwiatkowski DJ, Wdzieczak-Bakala J, Tu P, Liu J, Zha X, Zhang H. Brain Expressed X-Linked 2 Is Pivotal for Hyperactive mTOR-mediated Tumorigenesis. J Biol Chem. 2015; 290:25756-65.
4. Chen R, Li S, Liu G, Yuan Y, Liu J, Liu T, Wu R, Sun Q, Ren X, Yi X, Zhang H. Digital karyotyping with whole genome sequencing for complex congenital disorder. J Genet Genomics. 2015; 42:651-5
5. Jin D, Tao J, Li D, Wang Y, Li L, Hu ZD, Zhou ZZ, Chang XL, Qu CF, Zhang H. Golgi protein 73 activation of MMP-13 promotes hepatocellular carcinoma cell invasion Oncotarget. 2015; 6:33523-33.
6. Zha X, Hu Z, Ji S, Jin F, Jiang K, Li C, Zhao P, Tu Z, Chen X, Di L, Zhou H, Zhang H. NFκB up-regulation of glucose transporter 3 is essential for hyperactive mammalian target of rapamycin-induced aerobic glycolysis and tumor growth. Cancer Lett. 2015; 359:97-106
7. Zhang L, Liu L, He Z, Li G, Liu J, Song Z, Jin H, Rudolph KL, Yang H, Mao Y, Zhang L, Zhang H, Xiao Z, Ju Z. Inhibition of Wild-type p53-induced phosphatase 1 promotes liver regeneration in mice by direct activation of mTOR. Hepatology. 2015; 61:2030-41
8. Liu Z, Chen X, Wang Y, Peng H, Wang Y, Jing Y, Zhang H. PDK4 Protein Promotes Tumorigenesis through Activation of cAMP-response Element-binding Protein (CREB)-Ras Homolog Enriched in Brain (RHEB)-mTORC1 Signaling Cascade. J Biol Chem. 2014; 289:29739-49 (Paper of the Week).
9. Wang F, Chen X, Li C, Sun Q, Chen Y, Wang Y, Peng H, Liu Z, Chen R, Liu K, Yan H, Ye BH, Kwiatkowski DJ, Zhang H. Pivotal role of augmented αB-crystallin in tumor development induced by deficient TSC1/2 complex. Oncogene. 2014; 33:4352-8.
10. Liu Z, Xu KF, Hu C, Chen R, Duan J, Shi Y, Wang Y, Zhang W, Moss J, Wu J, Zhang H.  Use of whole-exome sequencing for the diagnosis of atypical Birt-Hogg-Dubé syndrome.  J Genet Genomics. 2014; 41: 449-151
11. Ma A, Wang L, Gao Y, Chang Z, Peng H, Zeng N, Gui YS, Tian X, Li X, Cai B, Zhang H, Xu KF. Tsc1 deficiency-mediated mTOR hyperactivation in vascular endothelial cells causes angiogenesis defects and embryonic lethality. Hum Mol Genet. 2014; 23: 693-705
12. Zhu L, Yang T, Li L, Sun L, Hou Y, Hu X, Zhang L, Tian H, Zhao Q, Peng J, Zhang H, Wang R, Yang Z, Zhang L, Zhao Y. TSC1 controls macrophage polarization to prevent inflammatory disorder. Nature Commun. 2014; 5:4696.
13. Wang Y, Hu Z, Liu Z, Chen R, Peng H, Guo J, Chen X, Zhang H. MTOR inhibition attenuates DNA damage and apoptosis through autophagy-mediated suppression of CREB1. Autophagy. 2013; 9: 2069-86
14. Peng H, Liu J, Sun Q, Chen R, Wang Y, Duan J, Li C, Bin Li, Jing Y, Chen X, Mao Q, Xu KF, Walker CL, Li J, Wang J, Zhang H. mTORC1 enhancement of STIM1-mediated store-operated Ca2+ entry constrains tuberous sclerosis complex-related tumor development. Oncogene. 2013; 32: 4702-11
15. Li H, Wang J, Xu H, Xing R, Pan Y, Li W, Cui J, Zhang H, Lu Y. Decreased fructose-1,6-bisphosphatase-2 expression promotes glycolysis and growth in gastric cancer cells. Mol Cancer. 2013; 12(1):110
16. Dai C, Zhang B, Liu X, Ma S, Yang Y, Yao Y, Feng M, Bao X, Li G, Wang J, Guo K, Ma W, Xing B, Lian W, Xiao J, Cai F, Zhang H, Wang R. Inhibition of PI3K/AKT/mTOR pathway enhances temozolomide-induced cytotoxicity in pituitary adenoma cell lines in vitro and xenografted pituitary adenoma in female nude mice. Endocrinology. 2013; 154: 1247-1259.
17. Gui YS, Wang L, Tian X, Ma A, Cai B, Zhang H, Xu KF. SPC-Cre-ERT2 transgenic mouse used for temporal gene deletion in mouse alveolar epithelial cells. PLoS One 2012；7: e46076
18. He J, Kang L, Wu T, Zhang J, Wang H, Gao H, Zhang Y, Huang B, Liu W, Kou Z, Zhang H, Gao S. An elaborate regulation of mTOR activity is required for somatic cell ​reprogramming​ induced by defined ​transcription​ factors. Stem Cells Dev. 2012; 21: 2630-41.
19. Zhang Y, Du XL, Wang CJ, Lin DC, Ruan X, Feng YB, Huo YQ, Peng H, Cui JL, Zhang TT, Wang YQ, Zhang H, Zhan QM, Wang MR. Reciprocal activation between PLK1 and Stat3 contributes to survival and proliferation of esophageal cancer cells. Gastroenterology. 2012; 142: 521-30.