Speaker: Prof. Christof Niehrs (Institute of Molecular Biology, Mainz, Germany)
Title：Novel regulators of Wnt-LRP6 signaling involved in embryonic development
Time: October 18 (Wednesday) 2017, 10: 30am
Venue: Laboratory of Southwestern Biodiversity, 1st floor conference room (1-24-26)
Everyone is welcome!
Introduction of the speaker:
Positions held
—2010 – 2015 Executive Director, Institute of Molecular Biology (IMB), Mainz
—Since 2010 Founding & Scientific Director, IMB, Mainz; Professor, Faculty of Biology, Johannes Gutenberg University Mainz (JGU)
—Since 2000 Professor of Molecular Embryology, German Cancer Research Center (DKFZ), Heidelberg
—Since 1994 Head of Division "Molecular Embryology", DKFZ, Heidelberg
—1990 –1993 Postdoc, University of California, Los Angeles (UCLA)
Education
—1997 Habilitation in Biology, University of Heidelberg
—1990 PhD in Biology, European Molecular Biology Laboratory (EMBL) and University of Heidelberg
—1985 Diploma in Biochemistry, Free University of Berlin
Research interest: Roles and regulation of Wnt signaling; DNA demethylation, DNA repair and reprogramming.
Representative Publications
1. Schomacher L. et al. (2016). Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation.Nat Struct Mol Biol. 23(2):116-124.
2. Koch S. et al. (2015). Post-transcriptional Wnt Signaling Governs Epididymal Sperm Maturation.Cell. 163(5):1225-1236.
3. Huang Y.L., et al. (2014). Maternal Wnt/STOP signaling promotes cell division during early Xenopus embryogenesis.Proc Natl Acad Sci U S A. 112(18):5732-7.
4. Acebron S.P. et al. (2014). Mitotic wnt signaling promotes protein stabilization and regulates cell size.Mol Cell54(4):663-74.
5. Huang Y.L., Niehrs C. (2014). Polarized Wnt signaling regulates ectodermal cell fate in Xenopus.Dev Cell. 29(2):250-7.
6. Cruciat C.M. et al. (2013). RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-β-catenin signaling.Science. 339(612-6):1436-41.
7. Schäfer A. et al. (2013). Ing1 functions in DNA demethylation by directing Gadd45a to H3K4me3.Genes Dev. 27(3):261-73.
8. Gierl M.S. et al. (2012).GADD45G functions in male sex determination by promoting p38 signaling and Sry expression.Dev Cell.23(5):1032-42.
9. Cruciat C.M. (2010), Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling. Science. 327(5964):459-63.
10. Bilic J. et al. Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation.Science. 316(5831):1619-22.
11. Barreto G et al. (2007) Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation.Nature.445(7128):671-5.
2017-10-12
