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Christof Niehrs (Institute of Molecular Biology, Germany) (October 18, 2017)
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2017-10-12

Speaker: Prof. Christof Niehrs (Institute of Molecular Biology, Mainz, Germany)  

TitleNovel regulators of Wnt-LRP6 signaling involved in embryonic development 

Time: October 18 (Wednesday) 2017, 10: 30am

Venue: Laboratory of Southwestern Biodiversity, 1st floor conference room (1-24-26)

Everyone is welcome! 

Introduction of the speaker:

Positions held 

2010 – 2015  Executive Director, Institute of Molecular Biology (IMB), Mainz

Since 2010  Founding & Scientific Director, IMB, Mainz; Professor, Faculty of Biology, Johannes Gutenberg University Mainz (JGU)

Since 2000  Professor of Molecular Embryology, German Cancer Research Center (DKFZ), Heidelberg

Since 1994  Head of Division "Molecular Embryology", DKFZ, Heidelberg

1990 –1993  Postdoc, University of California, Los Angeles (UCLA)

Education 

1997  Habilitation in Biology, University of Heidelberg

1990  PhD in Biology, European Molecular Biology Laboratory (EMBL) and University of Heidelberg

1985  Diploma in Biochemistry, Free University of Berlin

Research interest: Roles and regulation of Wnt signaling; DNA demethylation, DNA repair and reprogramming. 

Representative Publications 

  1. Schomacher L. et al. (2016). Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation.Nat Struct Mol Biol. 23(2):116-124. 

  2. Koch S. et al. (2015). Post-transcriptional Wnt Signaling Governs Epididymal Sperm Maturation.Cell. 163(5):1225-1236. 

  3. Huang Y.L., et al. (2014). Maternal Wnt/STOP signaling promotes cell division during early Xenopus embryogenesis.Proc Natl Acad Sci U S A. 112(18):5732-7. 

  4. Acebron S.P. et al. (2014). Mitotic wnt signaling promotes protein stabilization and regulates cell size.Mol Cell54(4):663-74. 

  5. Huang Y.L., Niehrs C. (2014). Polarized Wnt signaling regulates ectodermal cell fate in Xenopus.Dev Cell. 29(2):250-7. 

  6. Cruciat C.M. et al. (2013). RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-β-catenin signaling.Science. 339(612-6):1436-41. 

  7. Schäfer A. et al. (2013). Ing1 functions in DNA demethylation by directing Gadd45a to H3K4me3.Genes Dev. 27(3):261-73. 

  8. Gierl M.S. et al. (2012).GADD45G functions in male sex determination by promoting p38 signaling and Sry expression.Dev Cell.23(5):1032-42. 

  9. Cruciat C.M. (2010), Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling. Science. 327(5964):459-63. 

  10. Bilic J. et al. Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation.Science. 316(5831):1619-22. 

  11. Barreto G et al. (2007) Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation.Nature.445(7128):671-5. 

2017-10-12

 

 

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