|
|
| Protein ubiquitination regulates multiple cancer-related cellular processes, including cell cycle. Typically, it is sequentially mediated by three enzymes: ubiquitin-activating enzyme (E1), ubiquitin-conjugating enzyme (E2), and ubiquitin ligase (E3) that controls substrate specificity. During which, ubiquitin E3 ligases are considered to be the next wave of molecules for targeted therapy. Howe... more |
|
|
|
| Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are a class of fatal neurodegenerative maladies that affect various mammals, including cattle, sheep, mink, cervids, and human. During the past two decades, the epidemics of bovine spongiform encephalopathy (BSE) and its human form termed variant Creutzfeldt-Jakob disease (vCJD) have drawn special interests to the s... more |
|
|
|
Hedgehog (Hh) signaling plays pivotal roles in embryonic development and adult tissue homeostasis in species ranging from Drosophila to mammals. Malfunction of this pathway has been implicated in numerous human disorders including congenital anomalies and cancers, such as basal cell carcinoma, Medulloblastoma, lung cancer, liver cancer, etc. The Hh signaling is transduced by Smoothened (Sm... more |
|
|
|
| DNA methylation plays important biological roles in plants and animals. To examine the rice genomic methylation landscape and assess its functional significance, recently scientists from Kunming Institute of Zoology and their colleagues from Yunnan Academy of Agricultural Sciences, BGI-Shenzhen, Institute of Botany and Shanghai Cancer Institute generated single-base resolution DNA methylome map... more |
|
|
|
Human immunodeficiency virus infection / Acquired immunodeficiency syndrome (HIV/AIDS) is a disease of the human immune system caused by the human immunodeficiency virus. HIV has its high genetic variability and can be divided into two major types, HIV-1 and HIV-2. HIV-1 is the most common and pathogenetic strain of the virus.
For the pathology of HIV-1, dentritic cells (DCs), which were fi... more |
|
|
|
|
|
|
