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Scientists Lead to Reveal the Molecular Basis for Heat Desensitization of TRPV1 Ion Channels
TRPV1 is an important temperature sensing element in mammals , which can be activated by high temperatures above 40 ° C . However .Its role in sustained heat response remains poorly understood since a rapid heat-induced desensitization ( Dh ) process follows a tightly heat-induced activation ( Ah ) phase , and its function in mammalian biological activities remain elusive .Compared to the p-tr... more
Scientists discovered low immune activation in SIV-infected northern pig-tailed macaques (Macaca leonina)
Researchers Found New Evidences for Developing KLF5 as a Biomarker and Therapeutic Target for Breast Cancer Treatment
Breast cancer is one of the most common malignancies in women , recent researches indicated that transcription factor Kr üpple-like factor 5 ( KLF5 ) plays important roles in breast tumorigenesis .The previous studies showed KLF5 promotes breast cancer stem cell maintenance and self-renewal ( Theranostics , 2016 .( 4 ) : 533-544 ) , it is also reported that Klf5 plays a key role in maintaining... more
Pore-forming protein initiates scar-less healing
Tissue repair is a common problem during animal survival .However , scar tissue formation is a common by-product of human wound healing , which can lead to severe clinical dysfunction .Therefore , how to promote tissue regeneration and repair while reducing scar formation is an important issue .Amphibian skin plays an important physiological role in breathing and hydro-salinity balance , and it... more
Scientists Found A New Glioblastoma Classification Method
Heterogeneity is a basic characteristic of cancer , including intra-tumor heterogeneity and heterogeneity among patients mainly due to a variety of genetic alterations .CAS ) and Columbia University recently found a new method for GBM based on the genetic alterations of CDKN2A and TP53 genes with mutation rates of 60% and 30% respectively .Additionally , the activation of RAS pathway plus Cdkn2... more
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