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Molecular mechanism of tree shrew’s insensitivity to spiciness
Spicy foods elicit a pungent or hot and painful sensation that repels almost all mammals .Prof . LAI Ren ’ group from Kunming Institute of Zoology , Chinese Academy of Sciences and researchers from Zhejiang University observed that tree shrews ( Tupaia belangeri chinensis ) , which possess a close relationship with primates .Can directly and actively consume chili peppers , despite the deep ge... more
Pore-forming protein initiates scar-less healing
Tissue repair is a common problem during animal survival .However , scar tissue formation is a common by-product of human wound healing , which can lead to severe clinical dysfunction .Therefore , how to promote tissue regeneration and repair while reducing scar formation is an important issue .Compared with epidermal growth factor ( EGF ) widely used in clinic , this complex can not only promo... more
Salivary Factor from Aedes aegypti Facilitates Zika Virus Transmission
Identified in the 1940s in Africa , Zika is primarily spread by the bite of an infected mosquito .JIN Lin , GUO Xiaomin , SHEN chuanbin , HAO Xue ( Kunming Institute of Zoology , CAS ) and SUN Peng ( Tsinghua University ) are the co-first authors of this paper .CHENG Gong ( Tsinghua University ) , QI Xiaopeng and LAI Ren ( Kunming Institute of Zoology , CAS ) are the corresponding authors . ? ... more
How centipedes slay giant prey
Centipede rapidly subdues Kunming mouseThis study uncovers the molecular mode of action of centipede venom , which helps the tiny creatures subdue larger-bodied prey .Structural and functional analysis of this interaction revealed that two specific interacting residue pairs ( K13 - D266 and R12 - D288 ) are crucial to the toxin ' s effect on KCNQ4 . ? ? In vivo tests further revealed that SsT... more
Researchers Made New Progress in Expression Profiles and Regulatory Network of Alzheimer’s Disease
Recently , by using a systematic integrative analysis based on the largest collection of brain expression profiles of Alzheimer ’ s disease ( AD ) and other AD related omics data .They provided a complete and robust list of differential expressed genes ( DEGs ) in AD brain , and identified several candidate upstream regulators in the gene expression network .Homepage of AlzData ( Image by YAO ... more
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