He joined Kunming Institute Of Zoology in January 1999 as principal Investigator and the head of the laboratory of Biotoxin And Human Disease.His major research insterests are function and utilization of biotoxin,especially the function of host-derived pore-forming like protein from amphibianbombina maxima.Dr.ZHANG Yun was recipient of second prize of National Technological Invention Award (2013, ranked third ), First prize of Natural Science Award Of Yunnan Provience(2002, ranked first),First prize of Natural Science Award of Yunnan Province, (2008, ranked second);Second prize of Natural Science Award of Yunnan Province, (2004,ranked third);Third prize of Yunnan Provincial Science and Technology Progress Award(2013, ranked second); Individual Contribution Award of National "863" High Technology Research Program 15th Anniversary(2001); Special Allowance of State Council (2000); "Light of The West" Outstanding Scholar of the Organization Department of the CPC Central Committee and the Chinese Academy of Sciences (2006); Academic and Technical Leaders of young and middle-aged people in Yunnan province from Yunnan Provincial Government( 2002); Yunling Scholar of Yunnan Province(2015).He has been participated in completing the national “863”plan,national major drug creation and manufacture special project,”973”project. Undertaking national fund committee key project and Chinese academy of science key development project.

We are interested in study the function and ultilization of biotoxin,especially understanding the role of host-derived pore-forming like protein in amphibians’ vital activity.

Based on the abundant resources of poisonous animals in Yunnan province, our interests focused on the structure, function, mechanism and clinical application of bioactive polypeptides from venomous animals. In our work, we first reported an vertebrates-derived endogenous bacterial pore forming toxin-like protein and trefoil factor complex, which could activate the host innate immune through a novel cellular signaling regulation pathway (cover story, PNAS, 2014, independent corresponding author). Further study revealed that the complex has a ability to neutralize the acidifcation of endocytic organelles to counteract intracellular pathogens (J Infec Dis, 2017, independent corresponding author).Recent study revealed that the complex could promote wound healing and scar-free tissue repair (FASEB J, 2018,corresponding author).Our study revealed novel strategies and effector in vertebrate immune defense and intracellular pathogen elimination, providing new ideas and clues for further understanding the basic cellular biological issues of cellular vesiculation formation and regulation as well as related physiological and pathological effects.