CAS Center for Excellence in Animal Evolution and Genetics

LIANG Bin

2018-10-24 | | 【Print】

Dr. LIANG Binjoined Yunnan Academy of Agricultural Sciences as a Research Fellow from 1994 to 2004, and then joined Kunming Institute of Zoology, CAS in July 2010 as a Principal Investigator and the Head of the Laboratory of Lipid Metabolism and Diseases.

His major research interests are regulation of lipid droplet growth and primates models of human metabolic diseases.

Dr. LIANG was recipient of 100 Talent Project by CAS (2010), and Yunnan High Talent Project by Yunnan Provincial Science and Technology Department (2014).He is the chief scientist of the NSFC projects “The underlying mechanisms of fat accumulation in the tree shrew as well as the pathogenesis of non-obese alcoholic fatty liver diseases” and “The role of stearoyl-CoA desaturase in lipid metabolism”.

Research Interest

We are interesting in understanding the biosynthesis of lipids in lipid droplet growth, the functions of lipids and the pathogenesis of metabolic diseases such as obesity, fatty liver and diabetes.

Lipid droplets (LD) are intracellular organelle, and dynamically regulate energy homeostasis in response to intracellular and extracellular stimuli. Lipid droplets also involve in numerous biological processes such as virus infection, protein degradation, etc. Ectopic storage of lipid droplets in non-adipose tissues such as liver, muscle leads to fatty liver, diabetes. We use C. elegans, rodents, and mammalian cell lines via genetic, molecular, and biochemical technologies to investigate the underlying mechanisms of lipid droplet biogenesis and growth. Meanwhile, we take the advantages of the large populations of nonhuman primates tree shrew and rhesus monkey raised in Kunming Institute of Zoology, to generate models of human metabolic diseases in order for pathogenesis study and drug evaluation.

Selected Publications

1. Junlong Wang^#, Shimeng Xu^#, Jing Gao^#, Linqiang Zhang, Zhiguo Zhang, Wenhui Yang, Hu Zhou^*, Pingsheng Liu^*, and Bin Liang^*. SILAC-based quantitative proteomic analysis of the livers of spontaneous obese and diabetic rhesus monkeys. Am J Physiol Endocrinol Metab. doi.org/10.1152/ajpendo.00016.2018. (#Equal contribution)

2. Jieyu Wu^#,Xue Jiang^#, Yamei Li, Tingting Zhu, Jingjing Zhang,Zhiguo Zhang, Lingqiang Zhang, Yuru Zhang, Yanli Wang, Xiaoju Zou*, Bin Liang *. PHA-4/FoxA senses nucleolar stress to regulate lipid accumulation in Caenorhabditis elegans. Nature Communications. 2018 (#Equal contribution) 10.1038/s41467-018-03531-2.

3. Baoshen He#, Jingjing Zhang#, Yanli Wang, Yamei Li, Xiaoju Zou*, Bin Liang*. Identification of cytochrome b5 CYTB-5.1 and CYTB-5.2 in C. elegans; evidence for differential regulation of SCD. BBA-Molecular and Cell Biology of Lipids. 1863 (2018) 235–246 (#Equal contribution)

4. Zhang JJ, Hao JJ, Zhang YR, Wang YL, Li MY, Miao HL, Zou XJ*, Liang B*. Zinc Mediates the SREBP-SCD Axis to Regulate Lipid Metabolism in Caenorhabditis elegans. Journal of Lipid Research. 2017 58:(9) 1845-1854.（被选为当期封面文章）

5. Haizhen Wang#, Xue Jiang#, Jieyu Wu, Linqiang Zhang, Jingfei Huang, Yuru Zhang, Xiaoju Zou*, Bin Liang*. Iron Overload Coordinately Promotes Ferritin Expression and Fat Accumulation in Caenorhabditis elegans. Genetics. 2016. doi: 10.1534/genetics.116. 186742 (#Equal contribution) (Comments by GENES to GENOMES https://genestogenomes.org/how-worms-that-pump-iron-get-fat/)

6. Yuru Zhang#, Haizhen Wang# , Jingjing Zhang# ,Ying Hu#, Linqiang Zhang, Xiaoyun Wu, Xiong Su, Tingting Li, Xiaoju Zou*, Bin Liang*. Cytochrome b5 reductase HPO-19 is required for biosynthesis of polyunsaturated fatty acids in Caenorhabditis elegans. BBA-Molecular and Cell Biology of Lipids. 2016.1861(4):310-319. doi: 10.1016/j.bbalip.2016.01.009. (#Equal contribution)

7. Shi X#, Li J#, Zou X, Greggain J, Rodkaer SV, Faergeman NJ, Liang B*, Watts JL*. (2013). Regulation of lipid droplet size and phospholipid composition by stearoyl-CoA desaturase. Journal of Lipid Research. 2504–2514. (#Equal contribution)

8. Yuru Zhang, Xiaoju zou, Yihong Ding, Haizhen Wang, Xiaoyun Wu, Bin Liang*. (2013). Comparative Genomics and Functional Study of Lipid Metabolic Genes in Caenorhabditis elegans. BMC Genomics.14:164. doi:10.1186/1471-2164-14-164. (Highly accessed)

9. Bin Liang, Mustapha Moussaif, Chih-Jen Kuan, J. Jay Gargus and Ji Ying Sze*. (2006) Serotonin targets the DAF-16/FOXO signaling pathway to modulate stress responses. Cell Metabolism, Dec;4(6):429-440. (Preview on Cell Metabolism, 2006 Dec; 4(6):415-417.)