CAS Center for Excellence in Animal Evolution and Genetics

Rong Liu

2018-10-24 | | 【Print】

Rong Liu, Ph.D. Dr. Liu was recipient of K.C. Wong Education Foundation Award, Chinese Academy of Sciences (2012), the National Science Fund for Excellent Young Scholars, Natural Science Foundation of China (2014), “Excellent Young Scientist”, Chinese Academy of Sciences (2014).She got supports from the National Natural Science Foundation of China, Yunnan Applied Basic Research Key Projects, and Chinese Academy of Sciences.We are interested in understanding the development of breast cancer and focusing on finding new diagnostic and therapeutic targets of breast cancers.

Research Interest

We are focusing on exploring the function of transcription factor KLF5, microRNA-153, etc. in breast cancer and stem cell maintenance using multiple models, such as cell models, patient-derived xenograft models, transgenic mouse models. Based on understanding the roles of these genes in breast cancer development, we will further screening small molecular drugs to target these genes to find more potential anti-cancer drugs for breast cancer treatment.

Selected Publications

Rong Liu*, Peiguo Shi, Zhongmei Zhou, Hailin Zhang, Wei Li, Hong Zhang, and Ceshi Chen*, Krüpple-like factor 5 is essential for mammary gland development and tumorigenesis, J Pathol, 2018, DOI: 10.1002/path.5153 (* co-corresponding author)

Huichun Liang, Ji Xiao, Zhongmei Zhou, Hailin Zhang, Zongcheng Li, Jian Sun, Fubing Li, Rong Liu*, and Ceshi Chen*, Hypoxia induces miR-153 through the IRE1α-XBP1 pathway to fine tune the HIF-1α/VEGFA axis in breast cancer angiogenesis, Oncogene, 2018, doi:10.1038/s41388-017-0089-8 (* co-corresponding author)

Yuqi Lin, Rong Liu*, Ping Zhao, Zheng Zheng, Jingan Huang, Yingying Zhang, Yu Gao, Haiying Chen, Suling Liu, Jia Zhou,* Ceshi Chen,* Haijun Chen*, Discovery of Novel Mifepristone Derivatives via Suppressing KLF5 Expression for the Treatment of Triple-Negative Breast Cancer, Eur J Med Che, 2018 Feb 25;146:354-367. (* co-corresponding author)

Liu R*, Shi P, Nie Z, Liang H, Zhou Z, Chen W, Chen H, Dong C, Yang R, Liu S, Chen C*. Mifepristone Suppresses Basal Triple-Negative Breast Cancer Stem Cells by Down-regulating KLF5 Expression. Theranostics. 2016 Feb 13;6(4):533-44. (* co-corresponding author)

Wang Z, Nie Z, Chen W, Zhou Z, Kong Q, Seth AK, Liu R*, Chen C*. RNF115/BCA2 E3 ubiquitin ligase promotes breast cancer cell proliferation through targeting p21Waf1/Cip1 for ubiquitin-mediated degradation, Neoplasia. 2013 Sep;15(9):1028-35. (* co-corresponding author).

Liu R, Dong J. T, Chen C. Role of KLF5 in Hormonal Signaling and Breast Cancer Development, Vitam Horm. 2013;93:213-25. (book chapter)

Zhi X, Zhao D, Wang Z, Zhou Z, Wang C, Chen W, Liu R*, Chen C*. E3 ubiquitin ligase RNF126 promotes cancer cell proliferation by targeting the tumor suppressor p21 for ubiquitin-mediated degradation, Cancer Res, 2013 Jan 1, 73(1):385-94. (* co-corresponding author).

Liu R, Zhou Z, Zhao D, Chen C. The induction of KLF5 transcription factor by progesterone contributes to progesterone-induced breast cancer cell proliferation and dedifferentiation. Mol Endocrinol. 2011, 25(7): 1137-44 (Cover article)

Liu R, Zhou Z, Huang J, Chen C. PMEPA1 promotes androgen receptor-negative prostate cell proliferation through suppressing the Smad3/4-c-Myc-p21Cip1 signaling pathway. J Pathol. 2011, 223(5):683-694

Shao S#, Liu R #, Wang Y, Song Y, Zuo L, Xue L, Lu N, Hou N, Wang M, Yang X, Zhan Q. Centrosomal Nlp is an oncogenic protein that is gene-amplified in human tumors and causes spontaneous tumorigenesis in transgenic mice. J Clin Invest. 2010 Feb 1; 120(2):498-507. (# co-first author)

Liu R, Zheng HQ, Zhou Z, Dong JT, Chen C. KLF5 promotes breast cell survival partially through fibroblast growth factor-binding protein 1-pERK-mediated dual specificity MKP-1 protein phosphorylation and stabilization. J Biol Chem. 2009 Jun 19; 284(25):16791-8.

Ji J#, Liu R#, Tong T, Song Y, Jin S, Wu M, Zhan Q. Gadd45a regulates beta-catenin distribution and maintains cell-cell adhesion/contact. Oncogene. 2007 Sep 27; 26(44):6396-405. (#co-first author) (IF:7.414)