CAS Center for Excellence in Animal Evolution and Genetics

ZHANG Zhigang

2018-10-24 | | 【Print】

ZHANG Zhigang Ph.D. His major research interests are animal gut microbiomes and animal adaptive evolution.Dr. ZHANG was recipient of Health Science and Technology Achievement Award in Yunnan Province (the second prize, 2013 and the first prize, 2017).He was also recipient ofReserve talents of young and middle-aged academic technology leaders in YunnanProvince.He is the major principal of Key deployment project of Chinese Academy of Sciences “Functional characteristics and regulation of gut microbiomes in domesticated animals”;He is also the principal of National Natural Science Foundation of China “Variation of rumen microbiome in yak and its adaptation to high-altitude”.

Research Interest

Professor Zhang's research programme focuses on providing insight into the role of gut microbiome in both health and disease in human & animals.

He unravels the (co-)evolution of animals and their gut microbiomes under both artificial selection and natural selection using multi-omics approaches such as (meta)genomics, (meta)transcriptomics, metabolomics and (meta)proteomics as well as systems biology. Using non-human primate models, he attempts to reveal the role of gut microbiome in the regulation of neurodegenerative disorder.

Selected Publications

1. Zhang Zhigang ⁽^#), Dongming Xu, Li Wang, Junjun Hao, JinFeng Wang, Xin Zhou, Weiwei Wang, Qiang Qiu, Xiaodan Huang, Jianwei Zhou, Ruijun Long^(*), Fangqing Zhao^(*), Peng Shi^(*).Convergent evolution of rumen microbiomes in high-altitude mammals. Current Biology, 2016, 26 (14):1873-1879. (^#First author)

2. Zhang Zhigang ⁽^#), Geng J, Tang X, Fan H, Xu J, Wen X, Ma Z, Shi P. Spatial heterogeneity and co-occurrence patterns of human mucosal-associated intestinal microbiota. ISME J, 2014, 8(4): 881-893. (^#First author)

3. Wu Tao ^(#), Zhang Zhigang^(#), Liu B, Hou D, Liang Y, Zhang J, Shi P. Gut microbiota dysbiosis and bacterial community assembly associated with cholesterol gallstones in large-scale study. BMC Genomics, 2013, 14(1): 669. (^#Co-first author) (Highly Assessed)

二、（共同）通讯作者文章：

4. Yanhui Li, Cheng-Gang Zou, Yu Fu, Yanhong Li, Qin Zhou, Bo Liu, Zhang Zhigang^(*), Juan Liu^(*). Oral microbial community typing of caries and pigment in primary dentition. BMC Genomics, 2016, 17(1):1-11. (*Co-correspondence author)

5. Li ZhiPeng, Wright A-DG, Si H, Wang X, Qian W, Zhang Zhigang^(*), Li G^(*). 2016. Changes in the rumen microbiome and metabolites reveal the effect of host genetics on hybrid crosses. Environmental Microbiology Reports, 2016, 8(6):1016-1023. (*Co-correspondence author)

6. Li Jilian, J. E. Powell, J. Guo, J. D. Evans, J. Wu, P. Williams, Q. Lin, N. A. Moran^(*) and Zhang Zhigang^(*). Two gut community enterotypes recur in diverse bumblebee species. Current Biology, 2015, 25(15): R652-R653. (^*Co-correspondence author)

7. Li Zhipeng, Wright A-D, Liu H, Bao K, Zhang T, Wang K, Cui X, Yang F, Zhang Zhigang^(*), Li G^(*).Bacterial community composition and fermentation patterns in the rumen of sika deer (Cervus nippon) fed three different diets. Microbial Ecology, 2015, 69(2): 307-318. (^*Co-correspondence author)

8. Li Zhipeng, A.-D. G. Wright, H. Liu, Z. Fan, F. Yang, Zhang Zhigang^(*) and G. Li^(*). Response of the rumen microbiota of sika deer (Cervus nippon) fed different concentrations of tannin rich plants. PLoS ONE, 2015, 10(5): e0123481. (^*Co-correspondence author)

9. Zhu Lin, A.-H. Lei, H.-Y. Zheng, L.-B. Lyu, Zhang Zhigang^(*) and Y.-T. Zheng^(*). Longitudinal analysis reveals characteristically high proportions of bacterial vaginosis-associated bacteria and temporal variability of vaginal microbiota in northern pig-tailed macaques (Macaca leonina). Zoological Research, 2015, 36(5): 285-298. (^*Co-correspondence author)

10. Geng Jiawei, Song Q, Tang X, Liang X, Fan H, Peng H, Guo Q ^(*), Zhang Zhigang ^(*). Co-occurrence of driver and passenger bacteria in human colorectal cancer. Gut Pathogens, 2014, 6(1): 26. (^* Co-correspondence author)

11. Li Zhipeng, Zhang Zhigang ^(*), Xu C, Zhao J, Liu H, Fan Z, Yang F, Wright A-DG, Li G ^(*). Bacteria and methanogens differ along the gastrointestinal tract of chinese roe deer (Capreolus pygargus. PLoS ONE, 2014, 9(12): e114513. (^*Co-correspondence author)

12. Ma Lanqing, Zou T, Yuan Y, Lv J, Dong X, Yang G, Zhu Y, Luo J, Zhang Zhigang ^(*), Yang J ^(*),Duodenal ferroportin is up-regulated in patients with chronic hepatitis C. PLoS ONE, 2014, 9(10): e110658. (*Co-correspondence author)

13. Zou Tong, Zhang Zhigang (*), Zou Chenggang, Chen Keping, Dai Yan, Tong Jiabin, Yu Xue, Liu Junpeng, Chen Dongke, Xu Hongtao, Shi Haifeng, Wang Zhilei, Wu Sujuan, Sun Chen, Cui Wen, Chen Hao, Yu Jun, Yang Jiefu(*). Subclinical infections of cardiac implantable electronic devices: Insights into the host–bacteria dialog from blood and pocket tissue with pyrosequencing. International journal of cardiology, 2014, 174(3): 545-549. (^*Co-correspondence author)

14. Zhang Zhigang ^(*#), Zhai H, Geng J, Yu R, Ren H, Fan H ^(*), Shi P ^(*). Large-scale survey of gut microbiota associated with MHE via 16S rRNA-based pyrosequencing. Am J Gastroenterol, 2013, 108(10): 1601-1611. (^*Co-correspondence author)

15. Geng Jiawei, Fan H, Tang X, Zhai H, Zhang Zhigang ^(*). Diversified pattern of the human colorectal cancer microbiome. Gut Pathogens, 2013, 5(1): 2. (^*Correspondence author)