CAS Center for Excellence in Animal Evolution and Genetics

LI Jiali

2018-12-05 | | 【Print】

Jiali Li, Ph.D
2007.02 - 2010.09 Rutgers University; Research Associate
2004.02 - 2007.01 Mount Sinai School of Medicine; Postdoctoral fellow
2000.09 - 2003.07 Shanghai Medical School, Fudan University; Ph.D., in Neurobiology

Work experience
2014.01 - present, Principal Investigator, Kunming Institute of Zoology, Chinese Academy of Sciences.
2010.09 - 2013.12 Research Assistant Professor, Rutgers University.

Research field
The biology of brain aging, Neurodegenerative diseases, Alzheimer’s disease, Epigenetics
5hmC-mediated epigenetic regulation in AD neurodegeneration (National Science Foundation of China); 2. Exploration of precise neuron circuit network by development of primate animal model (National Key Basic Research Program of China); Deciphering involvement of DNA demethylation in brain ageing using Rhesus monkey model (National Science Foundation of China)

Research Interest

My research interests are mainly focused on deciphering of the epigenetic bases in brain ageing and age-related neurodegenerative diseases. Among the laboratory’s accomplishments and ongoing activities are (i) noncoding RNAs-mediated regulations in the biology of brain aging and age-related neurodegenerative diseases; (ii) DNA methylation/demethylation-mediated epigenetic basis in the biology of brain aging and age-related neurodegenerative diseases; (iii) Development and study of nonhuman primate models of age-related neurodegenerative diseases.

Publications

(1) Xu KY, Chen D, Wang ZB, Ma J, Zhou J, Chen NH, Lv LB, Zheng YT, Hu XT, Zhang Y, Li JL*. 2018. Annotation and functional clustering of circRNA expression in rhesus macaque brain during aging. Cell Discovery. 4: 48.

(2) Liu SL, Wang ZB, Chen D, Zhang BW, Tian RR, Wu J, Zhang Y, Xu KY, Yang LM, Cheng C, Ma J, Lv LB, Zheng YT, Hu XT, Zhang Y, Wang XT, Li JL*. 2017. Annotation and cluster analysis of spatiotemporal and sex-related lncRNA expression in rhesus macaque brain. Genome Research, 27(9): 1608-1620.

(3) Jiang DW, Zhang Y, Hart RP, Chen JM, Herrup K, Li JL*. 2015. Alteration in 5-hydroxymethylcytosine-mediated epigenetic regulation leads to Purkinje cell vulnerability in ATM deficiency. Brain, 138(Pt 12): 3520~3536.

(4) Jiang DW, Wei S, Chen F, Zhang Y, Li JL*. 2017. TET3-mediated DNA oxidation promotes ATR-dependent DNA damage response. EMBO Reports, 18(5): 781~796.

(5) Li JL, Jiang DW. 2015. The role of epigenomics in the neurodegeneration of ataxia-telangiectasia. Epigenomics. 7(2): 137~141.

(6) Li JL, Hart RP; Mallimo EM, Swerdel MR, Kusnecov AW, Herrup K. 2013. EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia- telangiectasia , Nature Neuroscience.12, 16(12): 1745~1753.

(7) Li J, Chen J, Ricupero C, Hart RP, Schwartz MS, Kusnecov A, Herrup K. 2012. Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia. Nature Medicine. 18(5): 783~U182.

(8) Li JL, Chen JM, Vinters HV, Gatti RA, Herrup K. 2011. Stable Brain ATM Message and Residual Kinase-Active ATM Protein in Ataxia-Telangiectasia. Journal of Neuroscience. 18, 31(20): 7568~7577.

(9) Li JL, Han YR, Plummer MR, Herrup K. 2009. Cytoplasmic ATM in Neurons Modulates Synaptic Function, Current Biology. 19(26).

(10) Li JL, Xiang B, Su WJ, Zhang XQ, Huang YL, Ma L. 2003. Agonist-induced formation of opioid receptor-G protein-coupled receptor kinase (GRK)-G beta gamma complex on membrane is required for GRK2 function in vivo. Journal of Biological Chemistry. 278(32): 30219~30226.

(11) Zhu HY, Wang N, Yao L, Chen Q, Zhang R, Qian JC, Hou YW, Guo WW, Fan SJ, Liu SL, Zhao QY, Du F, Zuo X, Guo YJ, Xu Y, Li JL, Xue T, Zhong K, Song XY, Huang GM, Xiong W. 2018. Moderate UV Exposure Enhances Learning and Memory by Promoting a Novel Glutamate Biosynthetic Pathway in the Brain. Cell. 173(7): 1716-1727.

(12) Su LY, Li H, Lv L, Feng YM, Li GD. Luo R, Zhou HJ, Lei XG, Ma L, Li JL, Xu L, Hu XT, Yao YG. 2015. Melatonin attenuates MPTP-induced neurotoxicity via preventing CDK5-mediated autophagy and SNCA/alpha-synuclein aggregation. Autophagy. 11(10):1745-1759.