LIU Jiang  Ph.D

Education background

Dr. LIU Jiang received his Ph.D. degrees from Institute of Biophysics, Chinese Academy of Sciences in 2003.  He got his first Postdoc Training in University of Michigan from 2003 to 2005. Then he was trained as a postdoc in Yale University from 2005 to 2006.

 Work experience

He was appointed as research associate (assistant professor) in University of Chicago from 2006 to 2009 . He was recruited as a professor in Beijing Institute of Genomics in 2009.

Research field

Our group is trying to integrate genomics method to understand some fundamental questions in epigenetic inheritance and animal development.

Award

Dr. LIU Jiang was recipient of "Ten thousand plan" - National high level talents special support plan (2016)

 Project

He was the Principal Investigator of National Natural Science Foundation of China (31630040, 31425015, 31561130152, 91519306, 81171902, and 81402112).

Our lab used zebrafish as the model to study the DNA methylation inheritance. Strikingly, we found that Sperm DNA methylome is inherited by early embryos, while oocyte methylome is discarded (Cell , 2013).This finding indicates not only DNA sequences can be inherited, but also DNA methylome of sperm can be inherited by zebrafish embryos.

we also revealed the programming and inheritance of parental DNA methylomes in mammals (Cell, 2014).

We reported 3D Chromatin Structures of Mature Gametes and Structural Reprogramming during Mammalian Embryogenesis (Cell,2017).

Recently, our group has revealed how the “programming language” directs gene expression pattern in human early embryos (Cell,2018).

1.       Li, C., Fan, Y., Li, G., Xu, X., Duan, J., Li, R., Kang, X., Ma, X., Chen, X., Ke, Y., Yan, J., Lian, Y., Liu, P., Zhao, Y., Zhao, H., Chen, Y., Yu, Y. & Liu, J. DNA methylation reprogramming of functional elements during mammalian embryonic development. Cell Discov 4, 41 (2018).

2.       Gao, L., Wu, K., Liu, Z., Yao, X., Yuan, S., Tao, W., Yi, L., Yu, G., Hou, Z., Fan, D., Tian, Y., Liu, J., Chen, Z.J. * & Liu, J. * Chromatin Accessibility Landscape in Human Early Embryos and Its Association with Evolution. Cell 173, 248-259 e15 (2018).

3.       Li, G., Yu, Y., Fan, Y., Li, C., Xu, X., Duan, J., Li, R., Kang, X., Ma, X., Chen, X., Ke, Y., Yan, J., Lian, Y., Liu, P., Zhao, Y., Zhao, H., Chen, Y., Sun, X., Liu, J., Qiao, J. * & Liu, J. * Genome wide abnormal DNA methylome of human blastocyst in assisted reproductive technology. J Genet Genomics 44, 475-481 (2017).

4.       Ke, Y., Xu, Y., Chen, X., Feng, S., Liu, Z., Sun, Y., Yao, X., Li, F., Zhu, W., Gao, L., Chen, H., Du, Z., Xie, W., Xu, X., Huang, X. * & Liu, J. * 3D Chromatin Structures of Mature Gametes and Structural Reprogramming during Mammalian Embryogenesis. Cell 170, 367-381 e20 (2017).

5.       Yan, F., Wang, Y., Zhang, W., Chang, M., He, Z., Xu, J., Shang, C., Chen, T., Liu, J., Wang, X., Pei, X. * & Wang, Y*. Human embryonic stem cell-derived hepatoblasts are an optimal lineage stage for hepatitis C virus infection. Hepatology 66, 717-735 (2017).

6.       Guo, Z.Q., Zheng, T., Chen, B., Luo, C., Ouyang, S., Gong, S., Li, J., Mao, L.L., Lian, F., Yang, Y., Huang, Y., Li, L., Lu, J., Zhang, B., Zhou, L., Ding, H., Gao, Z., Zhou, L., Li, G., Zhou, R., Chen, K., Liu, J., Wen, Y., Gong, L., Ke, Y., Yang, S.D., Qiu, X.B., Zhang, N., Ren, J., Zhong, D., Yang, C.G., Liu, J. * & Jiang, H *. Small-Molecule Targeting of E3 Ligase Adaptor SPOP in Kidney Cancer. Cancer Cell 30, 474-84 (2016).

7.       Chen, K., Zhang, J., Guo, Z., Ma, Q., Xu, Z., Zhou, Y., Xu, Z., Li, Z., Liu, Y., Ye, X., Li, X., Yuan, B., Ke, Y., He, C., Zhou, L., Liu, J. * & Ci, W. * Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer. Cell Res 26, 103-18 (2016).

8.       Zou, D., Sun, S., Li, R., Liu, J., Zhang, J. * & Zhang, Z. * MethBank: a database integrating next-generation sequencing single-base-resolution DNA methylation programming data. Nucleic Acids Res 43, D54-8 (2015).

9.       Wang, J. & Liu, J*. The programming of DNA methylation during vertebrate embryogenesis and gametogenesis. Progress in Biochemistry and Biophysics 42, 1047-53 (2015).

10.   Han, H., Du, Y., Zhao, W., Li, S., Chen, D., Zhang, J., Liu, J., Suo, Z., Bian, X., Xing, B. & Zhang, Z. * PBX3 is targeted by multiple miRNAs and is essential for liver tumour-initiating cells. Nat Commun 6, 8271 (2015).

11.   Ci, W. & Liu, J*. Programming and inheritance of parental DNA methylomes in vertebrates. Physiology (Bethesda) 30, 63-8 (2015).

12.   Wang, L., Zhang, J., Duan, J., Gao, X., Zhu, W., Lu, X., Yang, L., Zhang, J., Li, G., Ci, W., Li, W., Zhou, Q., Aluru, N., Tang, F., He, C., Huang, X. *  & Liu, J. *  Programming and inheritance of parental DNA methylomes in mammals. Cell 157, 979-91 (2014).

13.   Li, G., Ci, W., Karmakar, S., Chen, K., Dhar, R., Fan, Z., Guo, Z., Zhang, J., Ke, Y., Wang, L., Zhuang, M., Hu, S., Li, X., Zhou, L., Li, X., Calabrese, M.F., Watson, E.R., Prasad, S.M., Rinker-Schaeffer, C., Eggener, S.E., Stricker, T., Tian, Y., Schulman, B.A., Liu, J. * & White, K.P. *  SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer. Cancer Cell 25, 455-68 (2014).

14.   Jiang, L., Zhang, J., Wang, J.J., Wang, L., Zhang, L., Li, G., Yang, X., Ma, X., Sun, X., Cai, J., Zhang, J., Huang, X., Yu, M., Wang, X., Liu, F., Wu, C.I., He, C., Zhang, B., Ci, W. * & Liu, J. *  Sperm, but not oocyte, DNA methylome is inherited by zebrafish early embryos. Cell 153, 773-84 (2013).

15.   Liu, J., Ghanim, M., Xue, L., Brown, C.D., Iossifov, I., Angeletti, C., Hua, S., Negre, N., Ludwig, M., Stricker, T., Al-Ahmadie, H.A., Tretiakova, M., Camp, R.L., Perera-Alberto, M., Rimm, D.L., Xu, T., Rzhetsky, A. & White, K.P. *  Analysis of Drosophila segmentation network identifies a JNK pathway factor overexpressed in kidney cancer. Science 323, 1218-22 (2009).