Dr. LU Xuemei is a professor of Beijing Institute of Genomics, Chinese Academy of Sciences. Dr. LU started scientific career since 1997 when she received her Master degree from the South China Agricultural University. After 3-years professional training at the State Key Laboratory of Molecular Genetics and Evolution, in the Kunming Institute of Zoology in CAS, Dr. LU received her Ph.D. degree in Molecular Evolution in 2001. Dr. LU continued her postdoctoral research in the Center for Reproduction of Endangered Species, Zoological Society of San Diego from 2001 to 2002; and in the Department of Ecology and Evolution in the University of Chicago from 2003 to 2005. She was recruited to be an Associate Professor by School of Life Science, Sun Yet-Sen University in 2006 and promoted to Professor in Beijing Institute of Genomics in 2009. Dr. LU’s lab is currently focusing on genomic variations and evolution of complex traits and cancers.

（1） Yuezheng Zhang#, Yawei Li#, Tao Li#, Xu Shen#, Tianqi Zhu, Yong Tao, Xueying Li, Di Wang, Qin Ma, Zheng Hu, Jialin Liu, Jue Ruan, Jun Cai, Hurng-Yi Wang*, Xuemei Lu*. Genetic load and potential mutational meltdown in cancer cell populations. Molecular Biology and Evolution, (Accepted)

（2） Ying Xiang, Kai Yan, Qian Zheng, Haiqiang Ke, Jie Cheng, Wenjun Xiong, Xin Shi, Lei Wei, Min Zhao, Fei Yang, Ping Wang, Xing Lu, Li Fu, Xuemei Lu*, and Feng Li*. Histone demethylase KDM4B promotes DNA damage by activating long interspersed nuclear element-1 (LINE-1). Cancer Research. doi: 10.1158/0008-5472.CAN-18-1310. [Epub ahead of print]

（3） Yanting Luo#, Jianlin He#, Xiguang Xu, Ming-an Sun, Xiaowei Wu, Xuemei Lu*, Hehuang Xie.* Integrative single-cell omics analyses reveal epigenetic heterogeneity in mouse embryonic stem cells. PLoS Computational Biology 2018, 14(3): e1006034

（4） Wen Ye, Shaoping Ling, Ran‐Yi Liu, Zhi‐Zhong Pan, Gaoyuan Wang, Shijuan Gao, Jiangxue Wu, Lihua Cao, Lili Dong, Yingchang Li, Yi Zhou, Wuying Du, Xiangqi Meng, Jinna Chen, Xinyuan Guan, Yulong He, Changchuan Pan, XF Steven Zheng, Xuemei Lu* , Shuai Chen*, Wenlin Huang*. Exome sequencing reveals the genetic landscape and frequent inactivation of PCDHB3 in Chinese rectal cancers. Journal of Pathology. 2018, 245(2): 222-234

（5） Sixue Liu#, Zuyu Yang#, Guanghao Li#, Chunyan Li, Yanting Luo, Qiang Gong, Xin Wu, Tao Li, Zhiqian Zhang, Baocai Xing, Xiaolan Xu*, Xuemei Lu*. Multi-omics analysis in primary cell cultures reveal the genomic basis of phenotypic diversity within tumor. Genomics, Proteomics & Bioinformatics (Accepted)

（6） Furong Qi#, Airong Yang, Sadaf Ambreen, Xue Bai, Yali Hou*, Xuemei Lu*. Birth and death of Mx genes and the presence/absence of genes regulating Mx transcription are correlated with the diversity of anti-pathogenicity in vertebrate species. Molecular Genetics and Genomics. doi: 10.1007/s00438-018-1490-x. [Epub ahead of print]

（7） Chunyan Li#, Yali Hou#, Jin Xu#, Aiqun Zhang, Zhenzhen Liu, Furong Qi, Zuyu Yang, Ke Chen, Sixue Liu, Huanwei Huang, Qianfei Wang, Jiahong Dong, Chung-I Wu and Xuemei Lu*, A Direct Test of Selection in Cell Populations Using the Diversity in Gene Expression within Tumors, Molecular Biology and Evolution, 2017, 34(7):1730-1742

（8） Jin Xu#, Xinxin Peng#, Yuxin Chen#, Yuezheng Zhang, Qin Ma, Liang Liang, Ava C. Carter, Xuemei Lu* and Chung-I Wu*, Free-living human cells reconfigure their chromosomes in the evolution 1 back to uni-cellularity, eLife, 2017, 6. pii: e28070  （5Y-IF=8.385）

（9） Zuyu Yang^#, Mingming Jia^#, Guojing Liu, Huaining Hao, Li Chen, Guanghao Li, Sixue Liu, Yawei Li, Chung-I Wu, Xuemei Lu*, Shengdian Wang*, Genomic sequencing identifies a few mutations driving the independent origin of primary liver tumors in a chronic hepatitis murine model, Plos one, 2017;12(11):e0187551（5Y-IF=3.394）

（10）       Chung-I Wu^*, Hurng-Yi Wang, Shaoping Ling, Xuemei Lu*, The Ecology and Evolution of Cancer: The Ultra-Microevolutionary Process, Annual Review of Genetics, 2016, 50:347-369

（11）       Guojing Liu^#, Rui Zhang^#, Jin Xu, Chung-I Wu^*, Xuemei Lu*, Functional conservation of both CDS- and 3’UTR- located miRNA binding sites between species, Molecular Biology and Evolution, 2015, 32(3):623-628

（12）       Chunyan Li^#, Zhenzhen Liu^#, Fang Yang^#, Wensheng Liu, Di Wang, Encheng Dong, Yu Wang, Chung-I Wu, Xuemei Lu*, siRNAs with decreased off-target effect facilitate the identification of essential genes in cancer cells, Oncotarget, 2015, 6(25):21603-21613

（13）       Shaoping Ling^#, Zheng Hu^#, Zuyu Yang^#, Yang Fang^#, Yawei Li, Pei Lin, Ke Chen, Lili Dong, Lihua Cao, Yong Tao, Lingtong Hao, Qingjian Chen, Qiang Gong, Dafei Wu, Wenjie Li, Wenming Zhao, Xiuyun Tian, Chunyi Hao^*, Eric A. Hungate, Daniel V. T. Catenacci, Richard R. Hudson, Wen-Hsiung Li^*, Xuemei Lu^*, Chung-I Wu^*, Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution, Proc Natl Acad Sci U S A, 2015, 112(47):E6496-E6505

（14）       Tao Yong #, Hu Zheng #, Ling Shaoping #, Shiou-Hwie Yeh, Zhai Weiwei, Chen Ke, Li Chunyan, Wang Yu, Wang Kaile, Wang Hurng-Yi, Eric A Hungate, Kenan Onel, Liu Jiang, Zeng Changqing, Richard R Hudson, Chen Pei-Cher, Lu Xuemei *, Wu Chung-I *, Further genetic diversification in multiple tumors and an evolutionary perspective on therapeutics. bioRxiv, 2015, doi: http://dx.doi.org/10.1101/025429.

（15）       Xu Shen, Xue Bai, Jin Xu, Min Zhou, Haipin Xu, Qinghua Nie, Xuemei Lu^*, Xiquan Zhang^*, Transcriptome sequencing reveals genetic mechanisms underlying the transition between the laying and brooding phases and gene expression changes associated with divergent reproductive phenotypes in chickens, Molecular Biology Reports, 2016, 43(9):977-989