CAS Center for Excellence in Animal Evolution and Genetics

ZHENG Ping

2019-03-07 | | 【Print】

Research Interest

1. Preimplantation embryonic development:
We use the mouse as animal model to investigate the developmental biology of mammalian preimplantation embryos. We are interested in the regulatory roles of maternal accumulated factors in controlling early embryonic development. In particular, our previous work demonstrated that Filia, one of the components of subcortical maternal complex, was required for successful pre-implantation development as well as the maintenance of chromosome stability. However, the underlying molecular mechanism remains largely unknown. Our current effort is to define the molecular basis of these phenotypes.
2. Female gametogenesis:
Following primordial germ cell specification and germ cell sex determination, germ cells from males and females undergo distinct molecular changes leading to the formation of the mature gametes. We are investigating the molecular events regulating the development of female germ cells via in vivo and in vitro approaches.

Publications

1. Liu D^#, Wang X^#, He D^#, Sun C^#, He X, Yan L, Li Y, Han JJ*, Zheng P*. Single-cell RNA-sequencing reveals the existence of naive and primed pluripotency in pre-implantation rhesus monkey embryos. Genome Research, 2018, 28:1481–1493. (封面论文，期刊5年影响因子13.796)

2. Zhao B^#, Zhang WD^#, Cun YX, Li JZ, Liu Y, Gao J, Zhu HW, Zhou H, Zhang RG, Zheng P*. Mouse embryonic stem cells have increased capacity for replication fork restart driven by the specific Filia-Floped protein complex. Cell Research, 2018, 28(1):69-89. (期刊5年影响因子15.973)

3. Fan Y^#, Luo R^#, Su L-Y, Xiang Q, Yu D, Xu L, Chen J-Q, Bi R, Wu D-D, Zheng P*, Yao Y-G*. Does the genetic feature of the Chinese tree shrew (Tupaia belangeri chinensis) support its potential as a viable model for Alzheimer’s disease research? Journal of Alzheimers Disease, 2018; 61(3):1015-1028.

4. Wang XY^#, Liu DH^#, He DJ, Suo SB, Xia X, He XC, Han JJ*, Zheng P*. Transcriptome analyses of rhesus monkey pre-implantation embryos reveal a reduced capacity for DNA double strand break (DSB) repair in primate oocytes and early embryos. Genome Research, 2017, 27(4):567-579.

5. Li CH, Yan LZ, Ban WZ, Tu Q, Wu Y, Wang L, Bi R, Ji S, Ma YH, Nie WH, Lv LB, Yao YG*, Zhao XD*, Zheng P*. Long-term propagation of tree shrew spermatogonial stem cells in culture and successful generation of transgenic offspring. Cell Research, 2017, 27(2):241-252.

6. Guo K^#, Li CH^#, Wang XY, He DJ, Zheng P*. Germ stem cells are active in postnatal mouse ovary under physiological conditions. Molecular Human Reproduction, 2016, 22(5): 316-328 (该工作受到杂志同期特邀评论, Mol Hum Reprod, 2016, 22:313-315).

7. Lu YQ, He XC, Zheng P*. Decrease in expression of maternal effect gene Mater is associated with maternal ageing in mice. Molecular Human Reproduction, 2016, 22(4): 252-260.

8. Zhao B, Zhang WD, Duan YL, Lu YQ, Cun YX, Li CH, Guo K, Nie WH, Li L, Zhang R, Zheng P*. Filia is an ESC-specific regulator of DNA damage response and safeguards genomic stability. Cell Stem Cell, 2015, 16: 684-698. (期刊5年影响因子24.565)

9. Tan T^#, Zhang Y^#, Ji W*, Zheng P*. miRNA Signature in Mouse Spermatogonial Stem Cells Revealed by High-Throughput Sequencing. Biomed Res Int, 2014, 154251.

10. Zhao YQ^#, Ji S^#, Wang JK^#, Huang JF*, Zheng P*. mRNA-Seq and microRNA-Seq whole-transcriptome analysis of rhesus monkey ESC neural differentiation revealed the potential regulators of rosette neural stem cells. DNA Research, 2014, 21(5):541-54.

11. Zheng P*, Baibakov B, Wang XH, Dean J*. PtdIns(3,4,5)P3 is constitutively synthesized and required for spindle translocation during meiosis in mouse oocytes. Journal of Cell Science, 2013, 126(Pt 3):715-21.

12. Li L, Zheng P, Dean J*. Maternal control of early mouse development. Development, 2010, 137: 859-870.

13. Zheng P, Dean J*. Role of Filia, a maternal effect gene, in maintaining euploidy during cleavage stage mouse embryogenesis. Proc Natl Acad Sci USA, 2009, 106(18):7473-8.

14. Ohsugi M, Zheng P, Baibakov B, Li L, Dean J*. Maternally derived FILIA-MATER complex localizes asymmetrically in cleavage-stage mouse embryos. Development, 2008, 135(2):259-269.

15. Zheng P, Vassena R, Latham KE*. Effects of in vitro oocyte maturation and embryo culture on the expression of glucose transporters, glucose metabolism and insulin signaling genes in rhesus monkey oocytes and preimplantation embryos. Molecular Human Reproduction, 2007, 13: 361-371.