Wen Wang  Ph.D. Dr. Wen Wang got his bachelor degree in 1989 from Wuhan University, China. Dr. Wen Wang received his Ph.D. degrees in 1996 from Kunming Institute of Zoology, Chinese Academy of Sciences.

We are interested in the origin and evolution of genetic novelties under either natural or artificial selection, using genomic and evolutionary genomics approaches.

1. The mechanisms of new genes in the evolution of biological phenotypes

We used different animals to study mechanisms of origin and evolution genetic novelties, including the Lepidoptera butterflies, which are famous for their phenotypic diversity,.

2. Patterns of genome evolution and large-scale mining of genetic resources under artificially selection

We carried out large-scale comparative analysis through comparing the genomic and epigenetic differences between the domesticated species and their wild species. Based on these multiple species’ data, we aim to reveal the mechanisms of artificial selection, explore the genetic resources related to important traits, and provide important theoretical guidance and genetic resources for genetic breeding.

1.      Li XY, Fan DD, Zhang W, Liu GC, Zhang L, Zhao L, Fang X, Chen L, Dong Y, Chen Y, Ding Y, Zhao RP, Feng MJ, Zhu Y, Feng Y, Jiang XT, Zhu DY, Xiang H, Feng XK, Li SC, Wang J*, Zhang GJ*, Kronforst MR* &Wang W*. 2015. Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.Nature Communications. 6:8212.

2.       Zhou ZK, Jiang Y, Wang Z, Gou ZH, Lyu J, Li WY, Yu Y, Shu LP, Zhao YJ, Ma YM, Fang C, Shen YT, Liu TF, Li CC, Li Q, Wu M, Wang M, Wu YS, Dong Y, Wan WT, Wang X, Ding ZL, Gao YD, Xiang H, Zhu BG, Lee SK, Wang W* & Tian ZX*. 2015. Resequencing 302 wild and cultivated accessions identifies genes related to domestication and improvement in soybean. Nature biotechnology. 33(4):408-414.

3.       Jiang Y, Xie M, Chen WB, Talbot R, Maddox JF, Faraut T, Wu CH, Muzny DM, Li YX, Zhang WG, Stanton JA, Brauning R, Barris WC, Hourlier T, Aken BL, Searle SM, Adelson DL, Bian C, Cam GR, Chen YL, Cheng SF, DeSilva U, Dixen K, DongY, Fan GY, Franklin IR, Fu SY, Guan R, Highland MA, Holder ME, Huang GD, Ingham AB, Jhangiani SN, Kalra D, Kovar CL, Lee SL, Liu WQ, Liu X, Lu CX, Lv T, Mathew T, McWilliam S, Menzies M, Pan SK, Robelin D, Servin B, Townley D, Wang WL, Wei B, White SN, Yang XH, Ye C, Yue YJ, Zeng P, Zhou Q, Hansen JB, Kristiansen K, Gibbs RA, Flicek P, Warkup CC, Jones HE, Oddy VH, Nicholas FW, McEwan JC, Kijas J, Wang J, Worley KC*, Archibald AL*, Cockett N*, Xu X*, Wang W*& Dalrymple BP*. 2014. The sheep genome illuminates biology of the rumen and lipid metabolism. Science. 344(6188):1168-1173.

4.       Chen L, Tang LY, Xiang H, Jin LJ, Li QY, Dong Y, Wang W* and Zhang GJ*. 2014. Advances in genome editing technology and its promising application in evolutionary and ecological studies. GigaScience. (2015，IF= 7.463, 5year-IF= 11.660 ) 3:24.

5.       Lyu J, Zhang S, Dong Y, He W, Zhang J, Deng X, Zhang Y, Li X, Li B, Huang W, Wan W, Yu Y, Li Q, Li J, Liu X, Wang B, Tao D, Zhang G, Wang J, Xu X, Hu F* & Wang W*. 2013. Analysis of elite variety tag SNPs reveals an important allele in upland rice. Nature Communications. 4: 2138.

6.       Dong Y, Xie M, Jiang Y, Xiao NQ, Du XY, Zhang WG, Tosser-Klopp G, Wang JH, Yang S, Liang J, Chen WB, Chen J, Zeng P, Hou Y, Bian C, Pan SK, Li YX, Liu X, Wang WL, Servin B, Sayre B, Zhu B, Sweeney D, Moore R, Nei WH, Shen YY, Zhao RP, Zhang GJ, Li JQ, Faraut T, Womack J, Zhang YP, Kijas J, Cockett N, Xu X*, Zhao SH*, Wang J* & Wang W*. 2013. Sequencing and automated whole-genome optical mapping of the genome of a domestic goat (Capra hircus). Nature biotechnology. 31, 135-141.

7.       Ding Y, Zhou Q, Wang W*. 2012. Origins of New Genes and Evolution of their Novel Functions. Annual Review of Ecology and Systematics. 43：345-363.

8.       Zhan ZB, Ding Y, Zhao RP, Zhang Y, Yu HJ, Zhou Q, Yang S, Xiang H*, Wang W*. 2012. Rapid functional divergence of a newly evolved polyubiquitin gene in Drosophila and its role in the trade-off between male fecundity and lifespan. Molecular biology and Evolution. 29(5):1407-1416.

9.       Xu X, Liu X, Ge S, Jensen D J, Hu FY, Li X, Dong Y, Gutenkunst NR, Fang L, Huang Li, Li JX, He WM, Zhang GJ, Zheng XM, Zhang FM, Li YR, Yu C, Kristiansen K, Zhang XQ, Wang J, Wright M, McCouch S, Nielsen R*, Wang J*, Wang W*. 2012. Resequencing 50 accessions of cultivated and wild rice yields markers for identifying agronomically important genes. Nature Biotechnology. 30:105-111.

10.   Ding Y, Zhao L, Yang S, Jiang Y, Chen Y, Zhao RP, Zhang Y, Zhang GJ, Dong Y, Yu HJ, Zhou Q, Wang W*. 2010. A Young Drosophila Duplicate Gene Plays Essential Roles in Spermatogenesis by Regulating Several Y-Linked Male Fertility Genes. PLoS Genetics. 6(12):e1001255.

11.   Xiang H, Zhu JD, Chen Q, Dai FY, Li X, Li MW, Zhang HY, Zhang GJ, Li D, Dong Y, Zhao L, Lin Y, Cheng DJ, Yu J, Sun JF, Zhou XY, Ma KL, He YH, Zhao YX, Guo SC, Ye MZ, Guo GW, Li YR, Li RQ, Zhang XQ, Ma LJ, Kristiansen K, Guo QH, Jiang JH, Beck S, Xia QY*, Wang W*, Wang J*. 2010. Single base–resolution methylome of the silkworm reveals a sparse epigenomic map. Nature Biotechnology. 28:516-520.

12.   Li D, Dong Y, Jiang Y, Jiang HF, Cai J, Wang W*. 2010. A de novo originated gene depresses budding yeast mating pathway and is repressed by the protein encoded by its antisense strand. Cell Research. 20:408-420.

13.   Zhou Q, Zhang GJ, Zhang Y, Xu SY, Zhao RP, Zhan ZB, Li X, Ding Y, Yang S, Wang W*. 2008. On the origin of new genes in Drosophila. Genome Research. 18(9):1446-1455.

14.   Jiang HF, Guan WJ, Pinney D, Wang W*, Gu ZL*. 2008. Relaxation of yeast mitochondrial functions after whole genome duplication. Genome Research. 18(9):1466-1471.

15.   Li XY, Liang J, Yu HJ, Su B, Xiao C, Shang YF* & Wang W*. 2007. Functional consequence of new exon acquisition in mammalian CDYL genes. Trends in Genetics. 23:427-431.

Dr. Wen Wang has been a visiting student in Columbia University during 1995 to 1996. Dr. Wen Wang was research associate in Dr. Manyuan Long’s lab at University of Chicago from 1997 to 2002. He worked as a professor and was appointed as a leader of Max Planck Junior Scientist Group in Kunming Institute of Zoology, Chinese Academy of Sciences since 2002. Dr. Wen Wang received National Outstanding Youth Funds from NFSC in 2004; Dr. Wen Wang was selected in the first national list of the Trans-century (Hundred, Thousand and Ten Thousand) Talents Project in 2004;Dr. Wen Wang was awarded by the hundred Talent Program of the Chinese Academy of Sciences, In 2008;Dr. Wen Wang received K.C.Wong Outstanding Contribution Award of the Chinese Academy of Sciences for western scholars and CC Tan Innovation Prizes in Life Sciences in 2008;Dr. Wen Wang received the first grade prize of Natural Science Award of Yunnan Province in 2010; Dr. Wen Wang received the second grade prize of National Natural Science Award in 2010; Dr. Wen Wang received the second grade prize of Natural Science Award of Yunnan Province twice in 2017.

Projects