Academic Honors and Awards

1996 The award of natural science research of the Chinese Academy of Sciences

1997 The national award of natural science research of China

2002 The first-class award of natural science research of Yunnan province of

China

2003 The first-class award of natural science research of ministry of education, China

2005 The first-class award of natural science research of Yunnan province of

China

2007 The second-class national award of natural science research of China

2010 C.C. Tan Life Science Award

2012 The first-class award of natural science research of Yunnan province of

China

2013 The first-class award of natural science research of Yunnan province of

China

2014 Yun-ling scholar of Yunnan province of China

2015 Xing-dian Talent Award of Yunnan province of China

Editorial Board

Editorial Board, Zoological Research, China

Editorial Board, Scientific Reports, Nature Publishing Group

Editorial Board, PLoS One

Associate Editor, Molecular Biology and Evolution

Grants

1． Outstanding Oversea Chinese Scientists Fellowship (2001－2004）(Ranked as excellent and renewed in 2004)

2． National 863 Project Collection and genetic analysis of isolated ethnic populations in Yunnan (2002－2004）

3． National Science Foundation of China (NSFC) Project: Ancient DNA study of Neolithic populations from Yuanmou, Yunnan (2004－2006）

4． Natural Science Foundation of Yunnan Province, Molecular evolution of neuropsin gene and molecular mechanism of origin of primate cognition (2004－2006）

5． NSDC Director Fellowship: Comparative gene expression analysis of human and nonhuman primate brains and genetic mechanism of origin of human intelligence (2004－2005）

6． Key Project of Chinese Academy of Sciences: Genetic and evolutionary mechanism of origin of genome neo-structure and neo-function (2004－2006）

7． NSFC Outstanding Young Scientist Fellowship: Genetic mechanism of human origin (2006－2009）

8． National 973 Project－Study on animal cloning and therapeutic cloning of nonhuman primates (2006－2010）

9． NSFC Key Project: Genetic mechanism of primate brain evolution (2007-2010)

10． Key Project of Chinese Academy of Science: Genetic mechanism of primate brain evolution (2006-2009)

11． National 973 Project: The neural basis of human intelligence (2010-2014)

12． NSFC Key Project: Functional study of the key genes for primate brain evolution (2012-2016)

Research Interest

1. Primate comparative genomics and genetic mechanism of origin of human intelligence. Through genome wide comparative genetic analysis among living primates including humans, we aim to identify genes (protein coding genes and non-coding elements, e.g. microRNAs) undergone adaptive evolution with potential contribution to human CNS function, and to understand how genetic divergence leads to functional modification in primates.

2. Human population genetics. We study genetic variations in human populations to reconstruct prehistory of modern humans and to understand the role of natural selection in shaping up human genetic makeup and its relevance to human CNS diseases (e.g. schizophrenia).

Publications

1. Yang Z, …, Su B* 2018 Darwinian positive selection on the pleotropic effects of KITLG explain skin pigmentation and winter temperature adaptation in Eurasians. Molecular Biology and Evolution (in press)

2. Liu J, Li M, Luo X, Su B* 2018 Systems-level analysis of risk genes reveals the modular nature of schizophrenia. Schizophrenia Research DOI: https://doi.org/10.1016/j.schres.2018.05.015

3. He Y, Qi X, …, Su B*, Cui C* 2018 Adaptive change of circulating nitric oxide metabolites in Tibetans under high altitude hypoxia. National Science Review (published online, https://doi.org/10.1093/nsr/nwy037)

4. Liu JW and Su B* 2018 Integrated analysis supports AXN1 as a schizophrenia risk gene. Schizophrenia Research 195: 298-305.

5. Zhang H, He Y, Cui C, …, Su B* 2017 Cross-altitude analysis suggests a turning point at the elevation of 4,500m for polycythemia incidence in Tibetans. American Journal of Hematology DOI 10.1002/ajh.24809

6. Guo Y, He Y, …, Su B* 2017 GCH1 plays a role in high altitude adaptation of Tibetans. Zoological Research 38(3): 155-162.

7. Zheng W, He Y, …, Su B* 2017 EP300 contributes to high altitude adaptation of Tibetans by regulating nitric oxide production. Zoological Research 38(3): 163-170.

8. Peng Y, Cui C, He Y,…, Su B* 2017 Down-regulation of EPAS1 and genetic adaptation of Tibetans to high altitude hypoxia. Molecular Biology and Evolution 34(4):818-830.

9. Shi L, Hu E, Liu J, Li J, Li M, Chen H, Yu C, Jiang T, Su B* 2017 Regional selection of the brain size regulating gene CASC5 provides new insight into human brain evolution. Human Genetics DOI: 10.1007/s00439-016-1748-5

10. Bhandari S, Zhang X,…Su B* 2016 Sherpas share genetic variations with Tibetans for high-altitude adaptation. Molecular Genetics and Genomic Medicine DOI: 10.1002/mgg3.264.

11. Mendizabal I^#, Shi L^#, Keller TE, Konopka G, Preuss T, Hsieh T, Hu E, Zhang Z, Su B*, Yi SV* 2016 Comparative methylome analyses identify epigenetic regulatory loci of human brain evolution. Molecular Biology and Evolution 33(11):2947-2959.

12. Zhang X, Zhang Q, Su B* 2016 Emergence and evolution of inter-specific segregating retrocopies in cynomolgus monkey (Macaca fascicularis) and rhesus macaque (Macaca mulatta). Scientific Reports 6:32598.

13. Yang DY, Peng Y, Ouzhuluobu, Bianbazhuoma, Cui CY, Bianba, Wang LB, Xiang K, He YX, Zhang H, Zhang XM, Liu JW, Shi H, Pan YY, Duojizhuoma, Dejiquzong, Cirenyangji, Baimakangzhuo, Gonggalanzi, Liu SM, Gengdeng, Wu TY, Chen H, Qi XB, Su B* 2016 HMOX2 Functions as a Modifier Gene for High-Altitude Adaptation in Tibetans. Human Mutation 37:216-223.

14. Shi L, Zhang Z, Su B* 2016 Sex Biased Gene Expression Profiling of Human Brains at Major Developmental Stages. Scientific Reports 6:21181

15. Yang ZH, Zhong H, Chen J, Zhang XM, Zhang H, Luo X, Xu SH, Chen H, Lu DS, Han YL, Li JK, Fu LJ, Qi XB, Peng Y, Xiang K, Lin Q, Guo Y, Li M, Cao XY, Zhang YF, Liao SY, Peng YM, Zhang L, Guo XS, Dong SS, Liang F, Wang J, Willden A, Aun HS, Serey B, Sovannary T, Bunnath L, Samnom H, Mardon G, Li QW, Meng AM, Shi H, Su B* 2016 A genetic mechanism for convergent skin lightening during recent human evolution. Molecular Biology and Evolution 33(5):1177-1187.