CAS Center for Excellence in Animal Evolution and Genetics

CHEN Yongbin

2019-03-07 | | 【Print】

Yong-Bin Chen, Ph.D, Professor

Tel: 86-871-5176320 ; Fax: 86-871-5176312

E-mail: ybchen@mail.kiz.ac.cn

2012.05 – Present: Principal Investigator, Kunming Institute of Zoology, Chinese Academy of Sciences

2010.12 – 2012.05: Instructor, UT Southwestern Medical Center at Dallas, TX, USA

2005.12 – 2010.11: Postdoctoral Fellow, UT Southwestern Medical Center at Dallas, TX, USA

2000.09 –2005.07: PhD, Shanghai Institute of Biochemistry and Cell Biology, SIBS, CAS

1996.09 –2000.07: B.S. Wuhan University

Research Interest

The major interest of our lab is inductive signals involved in regulating tumor and stem cell. We use Drosophila, chicken, mouse, monkey and tree shrew as model systems to study the fundamental and prevalent mechanisms that control tumor and stem cells self-renew, proliferation, differentiation and so on. We are also establishing tumor models in the primate animals and developing drug screening platforms for serial cancers in the lab.

Publications

1. Yu, L#*., Wang, G.D#., Ruan, J#., Chen, Y.B#.,Yang, C.P#., Cao, X#., Wu, H#., Liu, Y.H#., Du, Z.L#., Wang, X.P#., Yang, J#., Cheng, S.C#., Zhong, L., Wang, L., Wang, X., Hu, J.Y., Fang, L., Bai, B., Wang, K.L., Zhang, J.G., Yang, Y.Q., Zhang, C.L., Long, Y.C., Li, H.S., Yang, J.Y., David M.I., Oliver A.R., Li, Y., Wu , S.F., Wu, C.I*., Zhang, Y.P*.2016. Genomic analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to high-altitude adaptation. Nature Genetics, 48, 947-952.(*Co-correspondence author, #Co-first author)

2. Yan, Y.M#., Wang, X.L#., Luo, Q#., Jiang, L.P., Yang, C.P., Hou, B., Zuo, Z. L*., Chen, Y.B*., Cheng, Y.X*., 2015. Metabolites from the mushroom Ganoderma lingzhi as stimulators of neural stem cell proliferation. Phytochemistry. 114:155-162.

3. Su,Z.Y.#., Yang,Z.Z.#., Xu, Y.Q., Chen, Y.B.#., Yu, Q.#., 2015. MicroRNAs in apoptosis, autophagy and necroptosis. Oncotarget, 6:8474-8490.

4. Tang, J.J., Zhang L., Jiang, L.P., Di, L., Yan, Y.M., Tu, Z.C., Yang, C.P., Zuo, Z.L., Hou, B, Xia, H.L., Chen, Y.B*., Cheng Y.X*.2014. Dopamine derivatives from the insect Polyrhachis dives as inhibitors of ROCK1/2 and stimulators of neural stem cell proliferation.Tetrahedron.70:8852-8857.

5. Yang, X.W#., Yang, C.P#., Jiang, L.P., Qin, X.J., Liu, Y.P., Shen, Q.S., Chen, Y.B*., Luo, X.D.* .2014. Indole Alkaloids with New Skeleton Activating Neural Stem Cells. Organic Letters. Oct 29 doi:10.1021/ol5029223.

6. 2. Chen, Y. B*., Jiang, J*. 2013. Decoding the phosphorylation code in Hedgehog signal transduction. Cell Research, 23, 186-200.

7. Yang, C. P., Chen, W. L., Chen, Y. B*., Jiang, J*. 2012. Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2. Cell Research, 22, 1593-1604.

8. Chen, Y. B., Sasai, N., Ma, G. Q., Yue, T., Jia, J. H., Briscoe, J., Jiang, J*. 2011. Sonic hedgehog dependent phosphorylation by CK1a and GRK2 is required for ciliary accumulation and activation of Smoothened. PLoS Biol, 9(6), e1001083. DOI:10.1371.

9. Chen, Y. B., Li, S., Tong, C., Zhao, Y., Wang, B., Liu, Y., Jia, J. H., Jiang, J*. 2010. G protein coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and -independent mechanisms in Drosophila. Genes Dev, 24, 2054 - 2067.