JIAO Baowei
2019-03-07 | | 【Print】

 

JIAO baowei

 

Education background

Dr. JIAO baowei got his bachelor and Master degree in 2000 from Southwest University in Chongqing, and received his Ph.D. degrees from the Chinese University of Hong Kong.From 2008 to 2013, he was postdoctoral fellow in Dr. Ingolf Bach's lab at University of Massachusetts Medical school.

 

Work experience

He joined the Chinese University of Hong Kong in May 2007 as Research Associate and joined the Kunming Institute of Zoology , Chinese Academy   of Sciences.

 

Research field

His major research interests are regulation of potassium channels and the aging of the nervous system. 

 

Project

He was the principal investigator of the National Science Foundation of China Grant“Mechanism of RLIM's regulation of breast stem cells” Strategic Priority Research Program of the Chinese Academy of Sciences Grant “Imprinted genes and complex traits evolve” National Key Research and Development Program of China Grant “The regulatory mechanism of X inactivation on breast stem cells and its application in breast cancer” National Key Research and Development Program of China Grant “In vivo study of cellular biological behavior after transplantation based on multimodality molecular imaging”.

Research Interest    
 

Epigenetics and developmental regulation

Epigenetics and developmental biology are indispensable disciplines of biological science for researchers to reveal the intrinsic relationship between genotypes and phenotypes. Jiao Baowei professor mainly focus on the characterization of the functional role of long noncoding RNA and epigenetic regulation (RNA splicing) in organ development (mammary gland development) and its pathological state (breast cancer). Based on high-throughput single-cell sequencing technology, the research team also uncovered the heterogeneity and cell lineage populations of organ development (mammary gland cancedevelopment and breast r).

 

Publications    

1.Wang S#, Ke H#, Zhang H, Ma Y, Ao L, Zou L, Yang Q, Zhu H, Nie J*, Wu C*, Jiao B*.2018.LncRNA MIR100HG promotes cell proliferation in triple-negative breast cancer through triplex formation with p27 loci. Cell Death Dis. 24;9(8):805. doi: 10.1038/s41419-018-0869-2.

2.Chen W# , Wang H# , Cheng M, Ni L, Zou L, Yang Q, Cai X, Jiao B*.2018. Isoharringtonine inhibits breast cancer stem-like properties and STAT3 Signaling. Biomed Pharmacother. 103:435-442.

3.Ke H#, Zhao L#, Zhang H#, Feng X, Xu H, Hao J, Wang S, Yang Q, Zou L, Su X, Wang L, Wu C, Wang Y, Nie J, Jiao B*, 2018.Loss of TDP43 inhibits progression of triple-negative breast cancer in coordination with SRSF3. Proc Natl Acad Sci U S A. .115(15):E3426-E3435.

4.Zhang H#, Yang X#, Feng X, Xu H, Yang Q, Zou L, Yan M, Liu D, Su X, Jiao B*. 2018 .Chromosome-wide gene dosage rebalance may benefit tumor progression. Mol Genet Genomics.     5. doi: 10.1007/s00438-018-1429-2.

5.Yang X, Wang H*, Jiao B*. 2017. Mammary gland stem cells and their application in breast cancer.Oncotarget. . 8(6):10675-10691.

6.Ke H, Zhao L, Feng X, Xu H, Zou L, Yang Q, Su X, Peng L, Jiao B*.2016. NEAT1 is Required for Survival of Breast Cancer Cells Through FUS and miR-548. Gene Regulation and Systems Biology, 10(Suppl 1):11-7.

7.Wu Y, Feng X, Gao L,Jiao B*. Imprinted genes: important regulators in development. Yi Chuan. 2016 Jun 20;38(6):508-522.

8.Shin J., Wallingford MC, Gallant J., Marcho C., Jiao B., Byron M., Bossenz M., Lawrence JB, Jones S., Mager J. & Bach I.          2013.RLIM is dispensable for X-chromosome inactivation in the mouse embryonic epiblast. Nature. 511(7507):86-

9.Jiao B, Güng?r C, Johnsen SA, Peters MA, Taniguchi-Ishigaki N, Chen YW, Riethdorf S, Drung A, Shin J, Pagnis R, Pantel K, Tachibana T, Lewis BC & Bach I. 2013. Functional activity of RLIM/Rnf12 is regulated by phosphorylation-dependent nucleocytoplasmic shuttling. Mol Biol Cell. 24(19):3085-96

10.Jiao B., Ma H., Shokhirev M., Drung A., Yang Q., Shin J., Lu S., Byron M., Kalantry S., Mercurio AM, Lawrence JB, Hoffmann A. and Bach I.. 2012. Paternal RLIM/Rnf12 is a survival factor for milk-producing alveolar cells. Cell.. 149:630-

 

 

 

+86 871 65199125cceaeg@mail.kiz.ac.cn
Chinese Academy of Sciences(CAS) Kunming Institute of Zoology, CAS Institute of Zoology (IOZ), CAS Shanghai Institute for Biological Sciences, CAS Academy of Mathematics and Systems Science, CAS
Institute of Genetics And Developmental Biology,CAS Institute of Hydrobiology,CAS Beijing Institute of Genomics, CAS Beijing Institute of Life Sciences,CAS Insititue of Vetebrate Plaeontology and Paleanthopolgy,CAS
Chengdu Institute of Biology, CAS Xi'an Branch, CAS University of Science and Technology of China