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Schizophrenia is a complex and heterogeneous disorder with a heritability about 80%. In recent years, benefiting from the results of large-scale research consortia and the development of sequencing technology, the genetics study of schizophrenia has made great progress. Genetic studies, including genome-wide association studies (GWASs), whole exome/genome sequencing (WES/WGS), and copy-num... more |
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| Zika virus (ZIKV) is an arbovirus and mainly transmitted in humans by several Aedes mosquitoes, especially Aedes aegypti. It has caused a series of epidemics in Africa and Asia since 1947. Its explosive outbreak in Brazil in 2015 and association with foetal microcephaly evoked global attention,and further prompted the World Health Organization to issue a global health emergency. In 2018, ZIKV r... more |
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Summary: A team led by CAS Fellow Ya-Ping Zhang and Prof. Zhanshan (Sam) Ma (Chinese Academy of Sciences) recently proposes a new concept, termed “individual-level genetic diversity.” The new concept is contrastingly different from existing concepts of genetic diversity, since existing genetic diversities (heterogeneities) have been traditionally defined and measured for population(s), r... more |
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Summary: In a paper published recently in Cell Press’s iScience, Professor Zhanshan (Sam) Ma (Chinese Academy of Sciences) tested the applicability of AKP (Anna Karenina principle) to the human microbiome-associated diseases, and further discovered that AKP effects are primarily influenced by highly dominant microbial species and less influenced by rare species.
The AKP refers to obse... more |
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AIDS (acquired immunodeficiency syndrome) is a transmissible disease of the immune system caused by the human immunodeficiency virus (HIV). HIV weakens a person’s immune system by destroying important cells that fight disease and infection.
The intestinal mucosa is among the earliest and most serious targets of HIV infection. However, due to technical and other difficulties, studies on in... more |
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