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Establishment of chronic morphine dependent model in three shrews
Tree shrews (Tupaia belangeri chinensis) belong to the Tupaiinae family, Scandentia order. Since tree shrew has small body size, easy to propagate and has a close relationship with primates, it is more advantageous than rodents in modeling human diseases. These features of tree shrew also make it a candidate model animal of potential human diseases and could partly substitute the high-price non... more
Recent study reveals the important role of Kunitz/BPTI gene family in the long-term blood feeding in hard ticks
Ticks are obligate blood-sucking ectoparasites of vertebrates throughout the world. They can transmit a wide variety of pathogens causing several human and animal diseases. Hard and soft ticks display different feeding strategies: hard ticks feed on blood for a few days to over one week, whereas soft ticks typically feed on blood for minutes to hours. Kunitz/BPTI proteins are abundant in the sa... more
A Systematic Analysis of Heart Transcriptome Highlights Divergent Cardiovascular Disease Pathways between Animal Models and Humans

  A fundamental and important parameter for developing appropriate human disease models is the knowledge of functional conservation of candidate human disease genes in the model organism. Animal models have proven useful for studying the genetic basis of cardiovascular disease (CVD), however, animal models fell short of the expected results, or even came out with opposite phenomena in many c... more
Prohibitins (PHBs) play novel role in protease activated receptor-1 mediated human platelets activation
Platelets are small disc-shaped cell fragments that undergo a rapid activation when they encounter exposed subendothelial matrix caused by vascular damage. Platelets adhere to subendothelial surfaces and become activated, causing them to aggregate and form a plug, which is responsible for primary haemostasis. Platelet activation is a complex process induced by a variety of stimuli, which act in... more
Being smart or stupid? Higher male fecundity but shorter lifespan
By reviewing the latest discovery of Kunming Institute of Zoology, the CAS, about the newly evolved gene CG11700 in drosophila,you will have to agree that “there is no free lunch” definitely is an iron rule. When the drosophila with null mutations of CG11700 have been proudly bestowed with high male fecundity, partial of their lifespan also have been deprived mercilessly.
  CG32744 and CG11... more
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