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Genomic Evidence Found for Domestication History of Asian Cultivated Rice
As one of the earliest domesticated crops by human being, rice has undergone significant phenotypic and physiological changes during the process of transformation from wild rice to cultivated rice that contains two major subspecies “indica and japonica”. However, the genome-wide variation patterns involved in the process remains a puzzle.
  In order to clarify the issue, the Kunming Institu... more
Natural Selection Plays Tricks at Reining mtDNAs in Tumorigenesis
No matter you like it or not, natural selection is already the key word in modern biology and you can find the signature of it at almost every corner of life science. Mitochondria are the powerhouse of eukaryotic cells. mtDNA is the structure converts the chemical energy into a form cells can use, ATP. Then, how does natural selection manipulate mitochondrial DNA (mtDNA) in tumorigenesis? Dr. K... more
Folate metabolism and neural crest development in Xenopus
Folic acid has been shown to have a protective effect against neurocristopathic malformations resulted from neural crest defects. However, the mechanism behind is largely unknown. The recent work by Dr. MAO Bing-yu’s group ( Kunming Institute of Zoology, Chinese Academy of Sciences) revealed that the folate metabolism pathway might regulate neural crest development epigenetically (Li et al., P... more
Late Bloomers: "New" Genes May Have Played a Role in Human Brain Evolution
Sixty "de novo" genes, many active in the cerebral cortex, arose from once-quiet stretches of DNA after humans split off from chimpanzees more than five million years ago
  Billions of years ago, organic chemicals in the primordial soup somehow organized themselves into the first organisms. A few years ago scientists found that something similar happens every once in awhile in the cells of al... more
Mitochondrial tRNAphe Variant m.593T>C increases the incidence of LHON in Chinese Families with m.11778G>A
Leber’s hereditary optic neuropathy (LHON) affects predominantly young (20-30 years old) adult males. Itis a mitochondrially inherited (mother to all offspring) degeneration of retinal ganglion cells (RGCs) and their axons that leads to an acute or sub-acute loss of central vision. Although the mechanism of LHON is relatively clear that the three pathogenic mitochondrial point mutations (MT-ND... more
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