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Folate metabolism and neural crest development in Xenopus
Folic acid has been shown to have a protective effect against neurocristopathic malformations resulted from neural crest defects. However, the mechanism behind is largely unknown. The recent work by Dr. MAO Bing-yu’s group ( Kunming Institute of Zoology, Chinese Academy of Sciences) revealed that the folate metabolism pathway might regulate neural crest development epigenetically (Li et al., P... more
Late Bloomers: "New" Genes May Have Played a Role in Human Brain Evolution
Sixty "de novo" genes, many active in the cerebral cortex, arose from once-quiet stretches of DNA after humans split off from chimpanzees more than five million years ago
  Billions of years ago, organic chemicals in the primordial soup somehow organized themselves into the first organisms. A few years ago scientists found that something similar happens every once in awhile in the cells of al... more
Mitochondrial tRNAphe Variant m.593T>C increases the incidence of LHON in Chinese Families with m.11778G>A
Leber’s hereditary optic neuropathy (LHON) affects predominantly young (20-30 years old) adult males. Itis a mitochondrially inherited (mother to all offspring) degeneration of retinal ganglion cells (RGCs) and their axons that leads to an acute or sub-acute loss of central vision. Although the mechanism of LHON is relatively clear that the three pathogenic mitochondrial point mutations (MT-ND... more
The Snake Cathelicdin Antimicrobial Peptide and Its Derivatives Receives Patent
Based on its potential as an excellent therapeutic agent, the snake cathelicdin antimicrobial peptide developed by the Kunming Institute of Zoology, the CAS, received a national invention patent in July 2011 (Patent No. ZL200810058260.9).
  According to the researchers, the snake cathelicdin peptide, which is highlighted by the merits of low cytoxity and hemolytic activity, has demonstrated s... more
The Antimicrobial Peptides Treasure locates in the Skins of Chinese Odorous Frogs
Odorous frogs are been famous thanks to their specialty of producing skin secretions with unpleasant smellswhen they are stimulated. And they also take the pivotal spot on the road of amphibian evolution as they are the important transitional type from rana to hylarana of ranid. Among the 20 odorous frog species worldwide, 13 could be found in China. This advantage facilitated the Dr. ZHANG Yu... more
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