|
|
Herbal medicine, as an important form of the Chinese traditional medicine, has a history of more that 2000 years. However, although people have been depending on them to relieve symptoms and cure diseases, the underlying biomedical mechanisms are quite little to known.
For example, the Tongshu Capsule (TSC), which is composed by eight traditional Chinese medicines: notoginseng, scandent sch... more |
|
|
|
| As a type of breast cancer with poorest prognosis and high relapse rate, the triple-negative breast cancer (TNBC) is characterized with no expressions of the genes of estrogen receptor (ER), progesterone receptor (PR) and Her2/neu. And because most chemotherapy need to target at one of the three receptors, the lack of gene expressions in TNBC has made it difficult to treat and often require com... more |
|
|
|
During the history of novel drug research and development, significant differences between mice, rats, dogs, monkeys and humans in drug absorption, distribution and excretion have resulted in massive losses and even total failures of drug application. Therefore, the availability of appropriate animals is critical for drug discovery.
In recent years, tree shrews (Tupaia belangeri chinensis) ... more |
|
|
|
| Breast cancer is a blanket term used to describe a variety of diseases, each with markedly different treatment options and prognosis for survival. In particular, ER/PR/HER2 triple-negative breast cancer (TNBC) is a highly aggressive form of breast cancer, which accounts for 15–25% of breast tumors. Given the state of research and prognosis of TNBC, there is a great need for novel therapeutics ... more |
|
|
|
| The long non-coding RNAs (lncRNA) are transcripts longer than 200 nucleotides and were initially considered as background noises of genomic transcription. Studies of these years showed that lncRNA actually plays active roles in many vital biological processes, such as inactivation of X chromosome, pluripotency maintenance of stems cells, transcriptional regulations and epigenetic regulations. A... more |
|
|
|
|
|
|
