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During the history of novel drug research and development, significant differences between mice, rats, dogs, monkeys and humans in drug absorption, distribution and excretion have resulted in massive losses and even total failures of drug application. Therefore, the availability of appropriate animals is critical for drug discovery.
In recent years, tree shrews (Tupaia belangeri chinensis) ... more |
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| Breast cancer is a blanket term used to describe a variety of diseases, each with markedly different treatment options and prognosis for survival. In particular, ER/PR/HER2 triple-negative breast cancer (TNBC) is a highly aggressive form of breast cancer, which accounts for 15–25% of breast tumors. Given the state of research and prognosis of TNBC, there is a great need for novel therapeutics ... more |
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| The long non-coding RNAs (lncRNA) are transcripts longer than 200 nucleotides and were initially considered as background noises of genomic transcription. Studies of these years showed that lncRNA actually plays active roles in many vital biological processes, such as inactivation of X chromosome, pluripotency maintenance of stems cells, transcriptional regulations and epigenetic regulations. A... more |
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| The evolution and differentiation of species is often accompanied by gene duplication events, which serve as a major mechanism creating new genes and expanding existing and gene families. Among primates, including humans, such changes have resulted in a large number of primate-specific genes or expanded gene families, some of which are related to certain phenotypic traits likely important to th... more |
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| Sheep and goats such common fixtures of pastoral and farming life that few bother to ask where they came from or how they became such major hallmarks of human agriculture and animal husbandry. The typical narrative to explain how these now ubiquitous goats and sheep were engrained in the collective imagination of the rural countryside is that they accompanied humans along their migrations along... more |
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