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Researchers Found New Mechanisms that PAQR4 Regulated Chemoresistance in Non-Small Cell Lung Cancer through Inhibiting Nrf2 Protein Ubiquitination and Degradation
  Lung cancer is the predominant cause of cancer related deaths. Within the main types of lung cancers, small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), NSCLC accounts for approximately 85%, with a poor 5-year survival of only ~15%. Despite the significant progress in treatment options, prognosis remains poor because of the locally advanced metastatic tumors in most patie... more
How and Why Men and Women Differ in Their Microbiomes?

  In a paper published very recently in Advanced Science, Prof. Sam MA and Ms. Wendy LI from Kunming Institute of Zoology, Chinese Academy of Sciences present seven aspects of the sex differences in the human microbiomes at 15 body sites, including oral, gut, skin and airway.
  Formally, the sex differences or sexual dimorphism in the human microbiomes are referred to as microgenderome, a ... more
Integrative Analysis Identified BTN3A2 as a Novel Schizophrenia Risk Gene

  Schizophrenia is a complex, highly heritable and heterogeneous disease with estimated heritability ranging up to 80%. It affects approximately 0.5-1% of the world population and causes significant global burdens. During the past decade, the genome-wide association studies (GWASs) have identified numerous schizophrenia-associated variants and loci in world-wide populations, but most of the ... more
Tumor Genome as “Living Fossil” Reveals Ancient Introgression from Coyotes to Pre-contact Dogs in North America

  Canine transmissible venereal tumor (CTVT), the oldest known somatic cell line, is a “living fossil” of the original host, transmitted from its tumor cells to other canids during the mating process. Since it was shown ten years ago that living cells from an ancient host could be transmitted among canids, the origin of CTVT has been studied continuously.
  Recent comparison of the CTVT ... more
Researchers Decipher Forces Shaping Maternal Genetic Landscape of Han Chinese

  As the world’s largest ethnic group, the genetic landscape of Han Chinese had been widely concerned during the last decades. Previous studies based on mitochondrial DNA (mtDNA) variants indicated a north-south maternal genetic divergence among Han populations. However, these studies mainly based on low-resolution mtDNA data of relatively limited samples, making the maternal genetic landsc... more
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